LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

August 30, 2021
Preprint
Open Access

Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2

BioRxiv : the Preprint Server for Biology
R. K. SinghW. Versees
April 29, 2021

How autophagy controls the intestinal epithelial barrier.

Autophagy
Elisabeth G FoersterDana J Philpott
February 3, 2021
Review

The Cell Biology of LRRK2 in Parkinson's Disease.

Molecular and Cellular Biology
Ahsan UsmaniAnnie Hiniker
December 22, 2020
Case Report
Open Access

A Specific Diplotype H1j/H2 of the MAPT Gene Could Be Responsible for Parkinson's Disease with Dementia

Case Reports in Genetics
Imane SmailiAhmed Bouhouche
December 5, 2020

Identification of Somatic Mutations in Dementia-related Genes in Cancer Patients.

Current Alzheimer Research
Yong-Chan Kim, Byung-Hoon Jeong
December 4, 2020
Review
Open Access

Pathological Functions of LRRK2 in Parkinson's Disease.

Cells
Ga Ram Jeong, Byoung Dae Lee
October 27, 2020
Review
Open Access

Genetics of Progressive Supranuclear Palsy: A Review.

Journal of Parkinson's Disease
Yafei WenLu Shen
August 20, 2020
Open Access

Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.

Nature
C. K. DenistonAndres E Leschziner
April 24, 2020
Review
Open Access

Targeting autophagy-related protein kinases for potential therapeutic purpose

Acta Pharmaceutica Sinica. B
Honggang XiangLiang Ouyang
January 6, 2020
Preprint
Open Access

Parkinson's Disease-linked LRRK2 structure and model for microtubule interaction

BioRxiv : the Preprint Server for Biology
C. K. DenistonAndres E Leschziner
July 10, 2019
Review
Open Access

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.

Autophagy
Anaïs LarabiHang Thi Thu Nguyen
July 1, 2019
Review
Open Access

Neuronal microtubules and proteins linked to Parkinson's disease: a relevant interaction?

Biological Chemistry
Alessandra CalogeroGraziella Cappelletti
March 30, 2017

Mechanisms of Mutant LRRK2 Neurodegeneration

Advances in Neurobiology
Mark R Cookson
February 17, 2017
Review
Open Access

LRRK2: from kinase to GTPase to microtubules and back

Biochemical Society Transactions
Marian Blanca RamírezSabine Hilfiker
September 8, 2016
Review
Open Access

Back to the tubule: microtubule dynamics in Parkinson's disease

Cellular and Molecular Life Sciences : CMLS
Laura PellegriniKirsten Harvey
April 21, 2016
Open Access

Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease

Molecular Neurodegeneration
Bruno A BenitezCarlos Cruchaga

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