LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

August 30, 2021
Open Access

Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2

BioRxiv : the Preprint Server for Biology
R. K. SinghW. Versees
April 29, 2021

How autophagy controls the intestinal epithelial barrier.

Elisabeth G FoersterDana J Philpott
February 3, 2021

The Cell Biology of LRRK2 in Parkinson's Disease.

Molecular and Cellular Biology
Ahsan UsmaniAnnie Hiniker
December 22, 2020
Case Report
Open Access

A Specific Diplotype H1j/H2 of the MAPT Gene Could Be Responsible for Parkinson's Disease with Dementia

Case Reports in Genetics
Imane SmailiAhmed Bouhouche
December 5, 2020

Identification of Somatic Mutations in Dementia-related Genes in Cancer Patients.

Current Alzheimer Research
Yong-Chan Kim, Byung-Hoon Jeong
December 4, 2020
Open Access

Pathological Functions of LRRK2 in Parkinson's Disease.

Ga Ram Jeong, Byoung Dae Lee
October 27, 2020
Open Access

Genetics of Progressive Supranuclear Palsy: A Review.

Journal of Parkinson's Disease
Yafei WenLu Shen
August 20, 2020
Open Access

Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.

C. K. DenistonAndres E Leschziner
April 24, 2020
Open Access

Targeting autophagy-related protein kinases for potential therapeutic purpose

Acta Pharmaceutica Sinica. B
Honggang XiangLiang Ouyang
January 6, 2020
Open Access

Parkinson's Disease-linked LRRK2 structure and model for microtubule interaction

BioRxiv : the Preprint Server for Biology
C. K. DenistonAndres E Leschziner
July 10, 2019
Open Access

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.

Anaïs LarabiHang Thi Thu Nguyen
July 1, 2019
Open Access

Neuronal microtubules and proteins linked to Parkinson's disease: a relevant interaction?

Biological Chemistry
Alessandra CalogeroGraziella Cappelletti
March 30, 2017

Mechanisms of Mutant LRRK2 Neurodegeneration

Advances in Neurobiology
Mark R Cookson
February 17, 2017
Open Access

LRRK2: from kinase to GTPase to microtubules and back

Biochemical Society Transactions
Marian Blanca RamírezSabine Hilfiker
September 8, 2016
Open Access

Back to the tubule: microtubule dynamics in Parkinson's disease

Cellular and Molecular Life Sciences : CMLS
Laura PellegriniKirsten Harvey
April 21, 2016
Open Access

Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease

Molecular Neurodegeneration
Bruno A BenitezCarlos Cruchaga

Sign up to follow this feed and discover related papers.

Related Feeds

3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.


TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alexander Disease

Alexander disease is a rare leukodystrophy caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research on this disease.

© 2022 Meta ULC. All rights reserved