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Lysosome & C9orf72
Debjyoti Bandyopadhyay et alThis feed focuses on the C9orf72 protein and its possible role in lysosome function and implication in frontotemporal dementia and amyotrophic lateral sclerosis
Top 20 most recent papers
The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology
Alzheimer's & Dementia : the Journal of the Alzheimer's AssociationOctober 18, 2019
Bradley F. BoeveLEFFTDS Consortium
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Molecular characterization of histopathological ependymoma variants
Acta NeuropathologicaNovember 2, 2019
Julia E NeumannUlrich Schüller
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Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention
Acta NeuropathologicaOctober 28, 2019
Emily A SloanJohn W Engstrom
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4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration
Acta NeuropathologicaOctober 16, 2019
Eri SaijoByron W Caughey
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Staufen 1 amplifies pro-apoptotic activation of the unfolded protein response.
bioRxivOctober 28, 2019
Mandi GandelmanStefan Matthias Pulst
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RNA toxicity in non-coding repeat expansion disorders
The EMBO JournalNovember 13, 2019
Bart SwinnenLudo Van Den Bosch
Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains
bioRxivOctober 21, 2019
Hitoki NanauraEiichiro Mori
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Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions
Acta NeuropathologicaOctober 31, 2019
Patricia Aguilar-CalvoChristina J Sigurdson
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The histomolecular criteria established for adult anaplastic pilocytic astrocytoma are not applicable to the pediatric population
Acta NeuropathologicaNovember 1, 2019
A GaretonPascale Varlet
Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
Acta NeuropathologicaOctober 23, 2019
Yoshihiro NiheiChristian Haass
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White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed
Neurobiology of AgingSeptember 27, 2019
Whitney M FreezeWalter H. Backes
A mitochondrial uncoupler prodrug protects dopaminergic neurons and improves functional outcome in a mouse model of Parkinson's disease
Neurobiology of AgingSeptember 26, 2019
Yuki KishimotoMark P. Mattson
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NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation
Acta NeuropathologicaOctober 29, 2019
Yanan YuNancy Ratner
C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis
Brain : a Journal of NeurologyOctober 24, 2019
Scott P AllenPamela Jean Shaw
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C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility
bioRxivNovember 8, 2019
Laura FumagalliPhilip Van Damme
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Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis
Acta NeuropathologicaNovember 7, 2019
Patrick OecklMarkus Otto
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Amyloid burden and white matter hyperintensities mediate age-related cognitive differences
Neurobiology of AgingAugust 31, 2019
Pénélope S DupontSven Joubert
Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges
Acta NeuropathologicaNovember 6, 2019
Shannon Shibata-GermanosJason Rihel
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Production of poly(GA) in C9ORF72 patient motor neurons derived from induced pluripotent stem cells
Acta NeuropathologicaOctober 17, 2019
Sandra AlmeidaFen-Biao Gao
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Functional maintenance in the multiple demand network characterizes superior fluid intelligence in aging
Neurobiology of AgingSeptember 20, 2019
Nianming ZuoTian-Zi Jiang
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