MAPK Pathway (Preprints)

MAPK pathway is a complex signaling pathway that regulates transcription, translation, cell cycle, and proliferation. Targeting this pathway has long been considered a promising strategy for cancer therapy. Here is the latest research on this pathway.

February 23, 2021
Preprint
Open Access

Loss of Muscleblind Splicing Factor Shortens C. elegans Lifespan by Reducing the Activity of p38 MAPK/PMK-1 and Transcription Factors ATF-7 and Nrf/SKN-1

BioRxiv : the Preprint Server for Biology
O. J. MatilainenSusana Garcia
February 18, 2021
Preprint
Open Access

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19.

BioRxiv : the Preprint Server for Biology
Dorien FeyaertsDavid R McIlwain
February 18, 2021
Preprint
Open Access

Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin.

BioRxiv : the Preprint Server for Biology
Yisong QianMingui Fu
February 12, 2021
Preprint
Open Access

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

BioRxiv : the Preprint Server for Biology
D. FeyaertsD. R. McIlwain
February 10, 2021
Preprint
Open Access

Methylation of KRAS at lysine 182 and 184 by SETD7 promotes KRAS degradation

BioRxiv : the Preprint Server for Biology
C. ChiangD. Zheng
February 9, 2021
Preprint
Open Access

Methylomic alteration in peripheral blood lymphocytes of prodromal stage and first-episode Chinese Han schizophrenia patients

BioRxiv : the Preprint Server for Biology
Y. LiuRenrong Wu
February 8, 2021
Preprint
Open Access

Extracellular vesicles induce aggressive phenotype of luminal breast cancer cells by PKM2 phosphorylation

BioRxiv : the Preprint Server for Biology
Seo Young KangD. S. Lee
February 7, 2021
Preprint
Open Access

Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosis

BioRxiv : the Preprint Server for Biology
W. W. CheungRobert H Mak
February 5, 2021
Preprint
Open Access

Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-inflammatory Cytokines

BioRxiv : the Preprint Server for Biology
S. Ahuja, Iulia M Lazar
February 3, 2021
Preprint
Open Access

Exaggerated cytokine production in human peripheral blood mononuclear cells by recombinant SARS-CoV-2 spike glycoprotein S1 and its inhibition by dexamethasone

BioRxiv : the Preprint Server for Biology
Olumayokun A OlajideA. A. Al-Hindawi
February 3, 2021
Preprint
Open Access

Central inhibition of P2Y12R differentially regulates survival and neuronal loss in MPTP-induced Parkinsonism in mice

BioRxiv : the Preprint Server for Biology
A. IringBeata Sperlagh
February 3, 2021
Preprint
Open Access

Voltage-Gated Potassium Channel Kv1.3 as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma

BioRxiv : the Preprint Server for Biology
W. LiSameer Patel
February 2, 2021
Preprint
Open Access

A novel positive feedback mechanism of ABI5 phosphorylation by mitogen activated protein kinase-3 regulates ABA signaling in Arabidopsis

BioRxiv : the Preprint Server for Biology
P. K. BhagatAlok Krishna Sinha
February 2, 2021
Preprint
Open Access

Cardiac fibroblast GSK-3α mediates adverse myocardial fibrosis via IL-11 and ERK pathway

BioRxiv : the Preprint Server for Biology
P. UmbarkarHind Lal
February 2, 2021
Preprint
Open Access

Isoform-specific functions of Numb in breast cancer progression, metastasis and proteome remodeling.

BioRxiv : the Preprint Server for Biology
Y. ZhangCatherine J McGlade
February 2, 2021
Preprint
Open Access

Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia

BioRxiv : the Preprint Server for Biology
S. A. CarrattJulia E Maxson
February 2, 2021
Preprint
Open Access

Catechin complexed with lysine has potent antitumor activities in human breast cancer xenograft model

BioRxiv : the Preprint Server for Biology
Elias N Katsoulieris, A. C. Rodriguez
February 1, 2021
Preprint
Open Access

Verapamil/Curcumin treatment attenuates the behavioral alterations observed in Williams Syndrome mice by regulation of MAPK pathway and Microglia overexpression

BioRxiv : the Preprint Server for Biology
P. Ortiz-RomeroVictoria Campuzano
February 1, 2021
Preprint
Open Access

The secreted peptide IRP functions as a DAMP in rice immunity

BioRxiv : the Preprint Server for Biology
P. WangYoji Kawano

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