Mechanisms of Prion Propagation

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Whilst some key players seem to have been identified so far, the mechanisms that underlie prion propagation to the brain are still not fully understood. Here is the latest research pertaining to mechanisms of prion propagation.

April 15, 2020

Short disordered protein segment regulates cross-species transmission of a yeast prion

Nature Chemical Biology
Toshinobu ShidaMotomasa Tanaka
May 29, 2020
Open Access

Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

ELife
Kirby M DonnellyMargaret M Panning Pearce
March 1, 2020
Open Access

Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms

The Journal of Biological Chemistry
Camilo Duque VelásquezDebbie McKenzie
July 14, 2020
Comment / Editorial
Open Access

Hiding in plain sight: vesicle-mediated export and transmission of prion-like proteins

Microbial Cell
Mehdi Kabani
September 18, 2020

Direct cathodic electron uptake coupled to sulfate reduction by Desulfovibrio ferrophilus IS5 biofilms

Environmental Microbiology
Alexandra L McCully, Alfred M Spormann
May 11, 2020
Review

Prions: Roles in Development and Adaptive Evolution

Journal of Molecular Evolution
Jamie D Dixson, Rajeev K Azad
May 7, 2020

The dual role of c-src in cell-to-cell transmission of α-synuclein

EMBO Reports
Yu Ree ChoiSang Myun Park
June 23, 2020
Review
Open Access

Genetic risk factors for Creutzfeldt-Jakob disease

Neurobiology of Disease
Emma Jones, Simon Mead
September 5, 2020

Multifunctional amyloid oligomeric nanoparticles for specific cell targeting and drug delivery

Biomacromolecules
Weiqiang WangSalvador Ventura
March 9, 2020
Preprint
Open Access

Rab27b regulates the release, autophagic clearance, and toxicity of alpha-synuclein

BioRxiv : the Preprint Server for Biology
Rachel UnderwoodTalene Yacoubian
April 17, 2020

LRP1 is a master regulator of tau uptake and spread

Nature
Jennifer N RauchKenneth S Kosik
August 29, 2020
Review
Open Access

Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays

Biomolecules
Matteo Manca, Allison Kraus
August 21, 2020

Cofilin 1 promotes the aggregation and cell-to-cell transmission of α-synuclein in Parkinson's disease

Biochemical and Biophysical Research Communications
Mingmin YanZhentao Zhang
August 18, 2020
Review
Open Access

Extracellular vesicles and amyotrophic lateral sclerosis: from misfolded protein vehicles to promising clinical biomarkers

Cellular and Molecular Life Sciences : CMLS
Delia GagliardiStefania Corti
July 2, 2020
Open Access

Efficient transmission of classical scrapie agent x124 by intralingual route to genetically susceptible sheep with a low dose inoculum

Research in Veterinary Science
Najiba MammadovaJustin J Greenlee
June 21, 2020

PrPSc Oligomerization Appears Dynamic, Quickly Engendering Inherent M1000 Acute Synaptotoxicity

Biophysical Journal
Simote T FoliakiSteven J Collins

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