Neurodegeneration: Misfolded Proteins

Protein misfolding is the primary cause of several neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease. This feed follows studies investigating protein misfolding in neurodegeneration.

January 20, 2022

Regulation of Neurodegeneration-associated Protein Fragments by the N-degron Pathways.

Neurotoxicity Research
Mohamed A EldeebRichard P Fahlman
January 20, 2022

Pharmacological inhibition of UPR sensor PERK attenuates HIV Tat-induced inflammatory M1 phenotype in microglial cells.

Cell Biochemistry and Function
Douglas Bardini SilveiraAguinaldo Roberto Pinto
January 19, 2022

Drosophila: A Model to Study the Pathogenesis of Parkinson's Disease.

CNS & Neurological Disorders Drug Targets
Rahul, Yasir Hasan Siddique
January 17, 2022

Metal Ions Bound to Prion Protein Affect its Interaction with Plasminogen Activation System.

The Protein Journal
Maryam Borumand, Vincent Ellis
January 17, 2022

Ganglioside binding domains in proteins: Physiological and pathological mechanisms.

Advances in Protein Chemistry and Structural Biology
Fodil AzzazJacques Fantini
January 16, 2022

Role of systems biology and multi-omics analyses in delineating spatial interconnectivity and temporal dynamicity of ER stress mediated cellular responses.

Biochimica Et Biophysica Acta. Molecular Cell Research
Priyanka MallickSaikat Chakrabarti
January 16, 2022

The modulation of neuroinflammation by inducible nitric oxide synthase.

Journal of Cell Communication and Signaling
Alberto Fernando Oliveira Justo, Claudia Kimie Suemoto
January 14, 2022

Body-first Parkinson's disease and variant Creutzfeldt-Jakob disease - similar or different?

Neurobiology of Disease
Amanda L Woerman, Gültekin Tamgüney
January 14, 2022

Braiding Braak and Braak: Staging patterns and model selection in network neurodegeneration.

Network Neuroscience
Prama PutraAlain Goriely
January 14, 2022

Force Spectroscopy in Mechanical Protein Domains Unfolding.

Advances in Experimental Medicine and Biology
Dionysios G Cheirdaris
January 13, 2022

Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease.

Pharmacological Reviews
Hilary Grosso JasutkarM Maral Mouradian
January 12, 2022
Open Access

The channel activities of the full-length prion and truncated proteins

BioRxiv : the Preprint Server for Biology
J. WuJinghui Luo
January 12, 2022
Open Access

Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies.

NPJ Vaccines
Changyoun KimMichael G Agadjanyan
January 12, 2022

Screening the Efficacy of Melatonin on Neurodegeneration Mediated by Endoplasmic Reticulum Stress, Inflammation, and Oxidative Damage.

Applied Biochemistry and Biotechnology
Fathima Hajee Basha, S Hemalatha
January 10, 2022

An expanding repertoire of protein acylations.

Molecular & Cellular Proteomics : MCP
Yuxuan XuLi Bao
January 10, 2022

Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.

Brain : a Journal of Neurology
Christopher HattonDaniel Erskine
January 9, 2022
Open Access

SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity.

Scientific Reports
Mariusz BerdyńskiMagdalena Kuźma-Kozakiewicz

Sign up to follow this feed and discover related papers.

Related Feeds

3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.


TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alexander Disease

Alexander disease is a rare leukodystrophy caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research on this disease.

© 2022 Meta ULC. All rights reserved