Molecular Mechanisms of Disease in ALS & FTD

Mutations in RNA-binding proteins, including TARDBP, have been found in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This feed focuses on molecular mechanisms that underlie ALS and FTD.

September 29, 2020
Review
Open Access

The Development of C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Disorders

Frontiers in Genetics
Qijie YangLu Shen
August 29, 2020

Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases.

International Review of Neurobiology
Yahyah AmanEvandro Fei Fang
October 15, 2020
Review

Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Xinnan LiYing Peng
January 8, 2021

Cytoplasmic granule formation by FUS-R495X is attributable to arginine methylation in all Gly-rich, RGG1 and RGG2 domains

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Daiki KawaharaTadashi Nakaya
September 9, 2020
Review

VPS10P Domain Receptors: Sorting Out Brain Health and Disease

Trends in Neurosciences
Anna R Malik, Thomas E Willnow
January 9, 2021
Open Access

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

ACS Chemical Neuroscience
Debasis PatnaikStephen J Haggarty
January 13, 2021
Open Access

Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

Neural Regeneration Research
Isaac G OnyangoGorazd B Stokin
December 2, 2020
Review
Open Access

What Can Machine Learning Approaches in Genomics Tell Us about the Molecular Basis of Amyotrophic Lateral Sclerosis?

Journal of Personalized Medicine
Christina VasilopoulouWilliam J Duddy
October 20, 2020
Review
Open Access

Amyotrophic Lateral Sclerosis: A Neurodegenerative Motor Neuron Disease With Ocular Involvement

Frontiers in Neuroscience
Pilar RojasJosé M Ramírez
September 16, 2020
Open Access

Untargeted metabolomics yields insight into ALS disease mechanisms

Journal of Neurology, Neurosurgery, and Psychiatry
Stephen A GoutmanEva L Feldman
September 18, 2020
Review
Open Access

Amyotrophic lateral sclerosis and lead: A systematic update.

Neurotoxicology
Cristiano FaraceRoberto Madeddu
December 10, 2020
Review
Open Access

Cerebral sterile inflammation in neurodegenerative diseases

Inflammation and Regeneration
Kento Otani, Takashi Shichita
November 16, 2020
Review

Western Pacific ALS-PDC: Evidence implicating cycad genotoxins

Journal of the Neurological Sciences
Peter S SpencerGlen E Kisby
August 20, 2020
Open Access

RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM.

Acta Neuropathologica Communications
Nandini RameshUdai Bhan Pandey
November 12, 2020
Open Access

Stress-Specific Spatiotemporal Responses of RNA-Binding Proteins in Human Stem-Cell-Derived Motor Neurons

International Journal of Molecular Sciences
Jasmine Harley, Rickie Patani
December 2, 2020
Review
Open Access

Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

International Journal of Molecular Sciences
M Catarina Silva, Stephen J Haggarty
August 29, 2020
Review
Open Access

Molecular and Cellular Mechanisms Affected in ALS

Journal of Personalized Medicine
Laura Le GallStephanie Duguez
December 8, 2020
Review
Open Access

The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALS

Frontiers in Cellular Neuroscience
María José Castellanos-MontielThomas M Durcan

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ALS & FTD: TDP-43

TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

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Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

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ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

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