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Molecular Mechanisms of Disease in ALS & FTD

Molecular Mechanisms of Disease in ALS & FTD diagram by Atthapon Raksthaput, Shutterstock
Atthapon Raksthaput, Shutterstock

Mutations in RNA-binding proteins, including TARDBP, have been found in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This feed focuses on molecular mechanisms that underlie ALS and FTD.

Top 20 most recent papers
Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics

Pathogenic Mechanisms and Therapy Development for C9orf72 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeuticsNovember 1, 2019
Jie Jiang, John Ravits
1
22
Brain : a Journal of Neurology

Homozygous GRN mutations: new phenotypes and new insights into pathological and molecular mechanisms

Brain : a Journal of NeurologyDecember 20, 2019
Vincent HuinIsabelle Le Ber
32
1
bioRxiv

Phase separation of toxic dipeptide repeat proteins related to C9orf72 ALS/FTD

bioRxivFebruary 1, 2020
Hamidreza JafariniaPatrick Onck
12
Nature Reviews. Neuroscience

Programmed axon degeneration: from mouse to mechanism to medicine

Nature Reviews. NeuroscienceMarch 11, 2020
Michael P Coleman, Ahmet Höke
36
1
Nature Reviews. Neurology

Protein transmission in neurodegenerative disease

Nature Reviews. NeurologyMarch 24, 2020
Chao PengVirginia M-Y Lee
95
1
Frontiers in Neuroscience

ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?

Frontiers in NeuroscienceDecember 24, 2019
Rita MejziniPatrick Anthony Akkari
9
1
Frontiers in Cellular Neuroscience

Molecular Mechanisms Linking ALS/FTD and Psychiatric Disorders, the Potential Effects of Lithium

Frontiers in Cellular NeuroscienceNovember 5, 2019
Fiona LimanaqiFrancesco Fornai
5
1
8
Trends in Pharmacological Sciences

Ropinirole, a New ALS Drug Candidate Developed Using iPSCs

Trends in Pharmacological SciencesJanuary 14, 2020
Hideyuki OkanoShinichi Takahashi
12
1
1
Methods in Molecular Biology

In Vitro Synthesis and RNA Structure Probing of CUG Triplet Repeat RNA

Methods in Molecular BiologyOctober 6, 2019
Remco T P van Cruchten, Derick G Wansink
1
5
Frontiers in Neuroscience

Structural Variants May Be a Source of Missing Heritability in sALS

Frontiers in NeuroscienceFebruary 22, 2020
Frances TheunissenPatrick Anthony Akkari
15
1

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