Myeloid-derived Suppressor Cells

MDSC (myeloid-derived suppressor cells) are a heterogenous group of immune cells from the myeloid lineage. MDSCs strongly expand in pathological situations such as chronic infections and cancer, as a result of an altered haematopoiesis. MDSCs are discriminated from other myeloid cell types in which they possess strong immunosuppressive activities rather than immunostimulatory properties.

September 17, 2021

Myeloid Malignancies: Recognizing the Risk of Germline Predisposition and Supporting Patients and Families.

Clinical Journal of Oncology Nursing
Patricia Friend, Suzanne M Mahon
September 17, 2021
Open Access

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression.

Frontiers in Immunology
Isak W TengesdalCharles A Dinarello
September 17, 2021

An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML.

Cancer Discovery
Shan LinKimberly Stegmaier
September 17, 2021

SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia.

Cancer Discovery
Yiliang WeiChristopher R Vakoc
September 17, 2021

Poly (ADP-ribose) polymerase-1 (PARP1) as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.

Blood Advances
Christina-Nefeli KontandreopoulouNora-Athina Viniou
September 17, 2021

Increased Blood Monocytic Myeloid Derived Suppressor Cells but Low Regulatory T Lymphocytes in Patients with Mild COVID-19.

Viral Immunology
Carlos Jiménez-CorteganaVíctor Sánchez-Margalet
September 16, 2021
Open Access

Construction of a solid Cox model for AML patients based on multiomics bioinformatic analysis

BioRxiv : the Preprint Server for Biology
Lei GaoY. Su
September 16, 2021

Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer.

Cancer Immunology, Immunotherapy : CII
Tomotaka UgaiShuji Ogino
September 16, 2021
Open Access

Novel Characterization of Myeloid-Derived Suppressor Cells in Tumor Microenvironment.

Frontiers in Cell and Developmental Biology
Yanan LiHengxiu Yan
September 16, 2021

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy.

Cell Stem Cell
Karrune V WoanFrank Cichocki

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