N-glycan Synthesis

N-glycan synthesis is the process where a N-glycan consisting of a large number of monosaccharides that are linked to a nitrogen, is produced. In eukaryotes, N-linked glycans are derived from a core 14-sugar unit assembled in the cytoplasm and endoplasmic reticulum (ER). First, two N-acetyl glucosamine residues are attached to dolichol monophosphate, a lipid, on the external side of the ER membrane. Five mannose residues are then added to this structure. At this point, the partially finished core glycan is flipped across the ER membrane, so that it is now located within the reticular lumen. Assembly then continues within the ER, with the addition of four more mannose residues. Finally, three glucose residues are added to this structure. Following full assembly, the glycan is transferred en bloc by the glycosyltransferase oligosaccharyltransferase to a nascent peptide chain, within the reticular lumen. This core structure of N-linked glycans, thus, consists of 14 residues (3 glucose, 9 mannose, and 2 N-acetylglucosamine). Discover the latest research on N-glycan synthesis here.

October 14, 2020
Preprint
Open Access

Genetics of Low Polygenic Risk Score Type 1 Diabetes Patients: rare variants in 22 novel loci

MedRxiv : the Preprint Server for Health Sciences
J. QuHakon Hakonarson
October 21, 2020
Open Access

Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins

Molecular & Cellular Proteomics : MCP
Yong ZhangHao Yang
October 13, 2020
Case Report

Immune dysfunction in MGAT2-CDG: A clinical report and review of the literature

American Journal of Medical Genetics. Part a
Sheri A PoskanzerChristina Lam
October 8, 2020
Open Access

Structure and anticancer activity of a new lectin from the cultivated red alga, Kappaphycus striatus

Journal of Natural Medicines
Le Dinh Hung, Phan Thi Hoai Trinh
October 18, 2020

Improved online LC-MS/MS identification of O-glycosites by EThcD fragmentation, chemoenzymatic reaction, and SPE enrichment

Glycoconjugate Journal
Shuang YangLawrence A Tabak
October 20, 2020
Open Access

PD-L1 Glycosylation and Its Impact on Binding to Clinical Antibodies

Journal of Proteome Research
Julius BenickyRadoslav Goldman
October 3, 2020
Open Access

High Mannose N-Glycans Promote Migration of Bone-Marrow-Derived Mesenchymal Stromal Cells

International Journal of Molecular Sciences
Vivian Alonso-GarciaFernando A Fierro
October 23, 2020
Review

Tunicamycin, an anticancer drug and inhibitor of N- linked glycosylation proteins is reliable to treat COVID-19

Microbial Pathogenesis
Ali Adel Dawood, Mahmood Abduljabar Altobje
October 13, 2020
Open Access

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

Nature
Christopher O BarnesPamela J Bjorkman
October 5, 2020

True significance of N-acetylglucosaminyltransferases GnT-III, V and α1,6 fucosyltransferase in epithelial-mesenchymal transition and cancer

Molecular Aspects of Medicine
Naoyuki TaniguchiYoshitaka Ikeda
October 22, 2020
Preprint
Open Access

Abnormal antibodies to self-carbohydrates in SARS-CoV-2 infected patients

BioRxiv : the Preprint Server for Biology
Dorothy L Butler, Jeffrey C. Gildersleeve
October 10, 2020
Open Access

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

Nature Communications
Edurne RujasJean-Philippe Julien

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