N-glycan Synthesis

N-glycan synthesis is the process where a N-glycan consisting of a large number of monosaccharides that are linked to a nitrogen, is produced. In eukaryotes, N-linked glycans are derived from a core 14-sugar unit assembled in the cytoplasm and endoplasmic reticulum (ER). First, two N-acetyl glucosamine residues are attached to dolichol monophosphate, a lipid, on the external side of the ER membrane. Five mannose residues are then added to this structure. At this point, the partially finished core glycan is flipped across the ER membrane, so that it is now located within the reticular lumen. Assembly then continues within the ER, with the addition of four more mannose residues. Finally, three glucose residues are added to this structure. Following full assembly, the glycan is transferred en bloc by the glycosyltransferase oligosaccharyltransferase to a nascent peptide chain, within the reticular lumen. This core structure of N-linked glycans, thus, consists of 14 residues (3 glucose, 9 mannose, and 2 N-acetylglucosamine). Discover the latest research on N-glycan synthesis here.

June 25, 2020
Open Access

Shielding and Beyond: The Roles of Glycans in SARS-CoV-2 Spike Protein

BioRxiv : the Preprint Server for Biology
Lorenzo CasalinoRommie E Amaro
July 2, 2020

Coronaviruses' sugar shields as vaccine candidates

Current Trends in Immunology
Denong Wang
July 1, 2020

Direct Analysis of Native N -Linked Glycans by IR-MALDESI

Journal of the American Society for Mass Spectrometry
Crystal L Pace, David C Muddiman
July 2, 2020
Open Access

Author Correction: Mutually exclusive locales for N-linked glycans and disorder in human glycoproteins

Scientific Reports
Shyamili GouthamRamray Bhat
July 4, 2020
Open Access

Selective cell-surface N-glycan editing

Nature Methods
Arunima Singh
July 10, 2020

Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination

Life Sciences
Ariane Sternberg, Cord Naujokat
July 3, 2020
Open Access

Recent Progress in Chemo-Enzymatic Methods for the Synthesis of N-Glycans

Frontiers in Chemistry
Qiang ChaoXiao-Dong Gao
June 23, 2020

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3

The EMBO Journal
Martina PigoniStefan F Lichtenthaler
July 1, 2020

β1,4-Galactosyltransferase V Modulates Breast Cancer Stem Cells through Wnt/β-catenin Signaling Pathway

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Wei TangJing Li
June 28, 2020

Alzheimer's disease: experimental and clinical researches of Chinese herbal medicine neurobiological effects (a review)

Advances in Gerontology = Uspekhi Gerontologii
M A BerezutskyO V Sinichkina
July 7, 2020

On-MALDI-target N-glycan nonreductive amination by 2-aminobenzoic acid

Analytical Chemistry
Xiaoping Li HronowskiRu Wei
July 6, 2020

N-glycosylation of High Mobility Group Box 1 protein (HMGB1) modulates the interaction with glycyrrhizin: A molecular modeling study

Computational Biology and Chemistry
Gérard Vergoten, Christian Bailly
June 26, 2020
Open Access

Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer

Protein & Cell
Jing ZhangTao Zhang
July 4, 2020

The Formidable Challenge of Controlling High Mannose-Type N-Glycans in Therapeutic mAbs

Trends in Biotechnology
Renato MastrangeliHorst Bierau

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