N-glycan synthesis is the process where a N-glycan consisting of a large number of monosaccharides that are linked to a nitrogen, is produced. In eukaryotes, N-linked glycans are derived from a core 14-sugar unit assembled in the cytoplasm and endoplasmic reticulum (ER). First, two N-acetyl glucosamine residues are attached to dolichol monophosphate, a lipid, on the external side of the ER membrane. Five mannose residues are then added to this structure. At this point, the partially finished core glycan is flipped across the ER membrane, so that it is now located within the reticular lumen. Assembly then continues within the ER, with the addition of four more mannose residues. Finally, three glucose residues are added to this structure. Following full assembly, the glycan is transferred en bloc by the glycosyltransferase oligosaccharyltransferase to a nascent peptide chain, within the reticular lumen. This core structure of N-linked glycans, thus, consists of 14 residues (3 glucose, 9 mannose, and 2 N-acetylglucosamine). Discover the latest research on N-glycan synthesis here.
AFM in situ DNA describes in situ analysis (or study) of DNA using atomic force microscopy. Discover the latest research on AFM in situ DNA here.
Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.
Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.
Cholesterol is essential for a variety of cellular processes, including cell growth and division, and it plays an important role in various signaling pathways. Here is the latest research on cholesterol synthesis and the role of cholesterol in cell signaling.
This feed focuses on cytochromes, including cytochrome C and the cytochromes P450 (CYP) enzyme system, and their involvement in the activation and inactivation of drugs.
Gangliosides are sialic acid-containing glycosphingolipids concentrated on cell surfaces and found in abundance in the nervous system. Gangliosides have several functions, including a role in cholesterol absorption. Here is the latest research.
Glycation refers to the covalent binding of a sugar molecule to a protein or lipid. Advanced glycation end proteins (AGEs) have been implicated in several diseases including neurogenerative diseases, diabetes, and atherosclerosis. Here is the latest research on glycation and AGEs.
Glycolipids are amphitropic compounds with one or more monosaccharide residues glycosidically linked to a lipid. Discover the latest research on glycolipids here.
Intrinsically disordered proteins exhibit biological activity even though they lack a well-defined 3D structure in solution. Here is the latest research on their role in cells.
Lipid metabolism refers to the synthesis and degradation of lipids in cells and is a complex process essential for fat storage and construction of cellular membranes. Discover the latest research on lipid and membrane metabolism here.