N-glycan Synthesis

N-glycan synthesis is the process where a N-glycan consisting of a large number of monosaccharides that are linked to a nitrogen, is produced. In eukaryotes, N-linked glycans are derived from a core 14-sugar unit assembled in the cytoplasm and endoplasmic reticulum (ER). First, two N-acetyl glucosamine residues are attached to dolichol monophosphate, a lipid, on the external side of the ER membrane. Five mannose residues are then added to this structure. At this point, the partially finished core glycan is flipped across the ER membrane, so that it is now located within the reticular lumen. Assembly then continues within the ER, with the addition of four more mannose residues. Finally, three glucose residues are added to this structure. Following full assembly, the glycan is transferred en bloc by the glycosyltransferase oligosaccharyltransferase to a nascent peptide chain, within the reticular lumen. This core structure of N-linked glycans, thus, consists of 14 residues (3 glucose, 9 mannose, and 2 N-acetylglucosamine). Discover the latest research on N-glycan synthesis here.

December 7, 2021

Towards understanding the extensive diversity of protein N-glycan structures in eukaryotes.

Biological Reviews of the Cambridge Philosophical Society
Charlotte ToustouMuriel Bardor
December 6, 2021
Preprint
Open Access

Salmonella enterica serovar Typhimurium chitinases modulate the intestinal glycome and promote small intestinal invasion.

BioRxiv : the Preprint Server for Biology
J. R. DevlinJudith Behnsen
December 6, 2021
Open Access

Improving Chicken Responses to Glycoconjugate Vaccination Against Campylobacter jejuni.

Frontiers in Microbiology
Harald NothaftChristine M Szymanski
December 6, 2021

[Application of serum N -glycan profiling diagnostic model in evaluation of liver fibrosis in patients with hepatitis C].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
X CaoH Zhuang
December 6, 2021

N-glycosylation structure - function characterization of omalizumab, an anti-asthma biotherapeutic product.

Journal of Pharmaceutical and Biomedical Analysis
Miklos SzaboAndras Guttman
December 5, 2021

Removal of single-site N-linked glycans on factor VIII alters binding of domain-specific monoclonal antibodies.

Journal of Thrombosis and Haemostasis : JTH
Jasmine ItoGlaivy Batsuli
December 4, 2021
Open Access

Serum N-Glycome Diversity in Teleost and Chondrostrean Fishes.

Frontiers in Molecular Biosciences
Kazuhiro AokiMichael Tiemeyer
December 4, 2021
Review
Open Access

Unique features of a recombinant haemagglutinin influenza vaccine that influence vaccine performance.

NPJ Vaccines
Arun B ArunachalamDeborah Rudin
December 3, 2021
Preprint
Open Access

Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

BioRxiv : the Preprint Server for Biology
X. LinHaibo Wu
December 3, 2021

Unexpected Off-Target Activities for Recombinant C5a in Human Macrophages.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Xaria X LiTrent M Woodruff
December 2, 2021

A novel fission yeast platform to model N-glycosylation and the bases of congenital disorders of glycosylation Type I.

Journal of Cell Science
Giovanna L GalloCecilia D'Alessio
December 2, 2021

What makes Komagataella phaffii non-conventional?

FEMS Yeast Research
Özge AtaBrigitte Gasser
December 2, 2021

Biofortified Whey/Deglycosylated Whey and Chickpea Protein Matrices: Functional Enrichment by Black Mulberry Polyphenols.

Plant Foods for Human Nutrition
Adem OzleyenTugba Boyunegmez Tumer

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