Neurodegeneration & Functional Genomics

Functional genomics techniques such as CRISPR/RNAi screens, microarrays, etc. can be employed to better understand complex mechanisms that underlie neurodegeneration. Here is the latest research.

January 17, 2021
Open Access

Inhibition of mitochondrial complex II in neuronal cells triggers unique pathways culminating in autophagy with implications for neurodegeneration.

Scientific Reports
Sathyanarayanan RanganayakiMuchukunte Mukunda Srinivas Bharath
December 17, 2020

EphrinB2-EphB2 signaling for dendrite protection after neuronal ischemia in vivo and oxygen-glucose deprivation in vitro

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Zhanyang YuXiaoying Wang
December 30, 2020
Open Access

Multivariate genome wide association and network analysis of subcortical imaging phenotypes in Alzheimer's disease

BMC Genomics
Xianglian MengAlzheimer’s Disease Neuroimaging Initiative
December 12, 2020
Open Access

Common Factors in Neurodegeneration: A Meta-Study Revealing Shared Patterns on a Multi-Omics Scale

Cells
Nicolas RuffiniSusanne Gerber
January 21, 2021
Preprint
Open Access

Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

BioRxiv : the Preprint Server for Biology
S. SunZhiyong Liu
November 26, 2020
Open Access

Siberian sturgeon multi-tissue reference transcriptome database

Database : the Journal of Biological Databases and Curation
Christophe KloppDenise Vizziano-Cantonnet
January 9, 2021

Unique Subtype of Microglia in Degenerative Thalamus After Cortical Stroke

Stroke; a Journal of Cerebral Circulation
Zhijuan CaoGary K Steinberg
January 6, 2021

ADeditome provides the genomic landscape of A-to-I RNA editing in Alzheimer's disease

Briefings in Bioinformatics
Sijia WuXiaobo Zhou
January 18, 2021
Open Access

ERAD deficiency promotes mitochondrial dysfunction and transcriptional rewiring in human hepatic cells

The Journal of Biological Chemistry
Qingqing LiuQiaoming Long
November 3, 2020
Preprint
Open Access

MULTI-ANCESTRY GENETIC STUDY IN 5,876 PATIENTS IDENTIFIES AN ASSOCIATION BETWEEN EXCITOTOXIC GENES AND EARLY OUTCOMES AFTER ACUTE ISCHEMIC STROKE

MedRxiv : the Preprint Server for Health Sciences
L. IbanezDerbis
January 16, 2021
Open Access

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease.

Neurobiology of Disease
Megan M SenchukDarren J Moore
January 5, 2021

Comprehensive Integrative Analyses Identify TIGD5 rs75547282 as a Risk Variant for Autism Spectrum Disorder

Autism Research : Official Journal of the International Society for Autism Research
Xinyan XieRanran Song
January 23, 2021

Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Hong-Dong LiNathan D Price
December 9, 2020

Overexpression of FKH-2/FOXG1 is neuroprotective in a C. elegans model of Machado-Joseph disease.

Experimental Neurology
Yasmin Fardghassemi, J Alex Parker
November 19, 2020
Open Access

Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression

Cell Reports
Jessica E RexachDaniel H Geschwind
December 11, 2020
Open Access

Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease

NPJ Parkinson's Disease
Meghan L BucherTeresa G Hastings

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