Feed Preview

Fast Growing

Neurodegeneration: Genetics

Neurodegeneration: Genetics diagram by

Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death, and leads to several diseases, including Alzheimer’s and Parkinson’s. This feed focuses on the genetic alterations that underlie neurodegeneration.

Top 20 most recent papers
Nature Genetics

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

Nature GeneticsJanuary 22, 2020
Jamie E CraigStuart MacGregor
Nature Neuroscience

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Nature NeuroscienceJanuary 22, 2020
Julia MarschallingerTony Wyss-Coray
Nature Ecology & Evolution

Evolution of a supergene that regulates a trans-species social polymorphism

Nature Ecology & EvolutionJanuary 22, 2020
Zheng YanLaurent Keller
Biological Psychiatry

Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover

Biological PsychiatryJanuary 21, 2020
Jiechao ZhouJie Zhang
1
1
International Journal of Molecular Sciences

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain

International Journal of Molecular SciencesJanuary 18, 2020
Motaz M FadulJulie E Simpson
Epigenetics : Official Journal of the DNA Methylation Society

Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence

Epigenetics : Official Journal of the DNA Methylation SocietyJanuary 17, 2020
Lucia ScisciolaAngela Nebbioso
Neuropharmacology

Approaches to develop therapeutics to treat frontotemporal dementia

NeuropharmacologyJanuary 22, 2020
Lisa P EliaSteven Finkbeiner
Human Molecular Genetics

Disruption of a RAC1-centred network is associated with Alzheimer's disease pathology and causes age-dependent neurodegeneration

Human Molecular GeneticsJanuary 17, 2020
Masataka KikuchiAkihiro Nakaya
1
International Journal of Molecular Sciences

P53 and The Immune Response: 40 Years of Exploration-A Plan for the Future

International Journal of Molecular SciencesJanuary 19, 2020
Arnold J Levine
Molecular Brain

ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration

Molecular BrainJanuary 22, 2020
Seiji WatanabeKoji Yamanaka
Human Molecular Genetics

Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease

Human Molecular GeneticsJanuary 22, 2020
Jonasz J WeberJeannette Hübener-Schmid
International Journal of Molecular Sciences

Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases

International Journal of Molecular SciencesJanuary 19, 2020
Marie-Claire MéchinMichel Simon
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine

Cataplexy and ataxia: red flags for the diagnosis of DNA methyltransferase 1 mutation

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep MedicineJanuary 21, 2020
Emanuela PostiglioneGiuseppe Plazzi
1
Brain and Behavior

The novel GLP-1/GIP analogue DA5-CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD

Brain and BehaviorJanuary 22, 2020
Cheng LiZhiju Wang
The Biochemical Journal

Lysosomal protein thermal stability does not correlate with cellular half-life: Global observations and a case study of tripeptidyl-peptidase 1

The Biochemical JournalJanuary 21, 2020
Aaron M CollierPeter Lobel
Molecular Genetics & Genomic Medicine

A case report of genetic prion disease with two different PRNP variants

Molecular Genetics & Genomic MedicineJanuary 19, 2020
Megan PiazzaBrian Appleby
2
Scientific Reports

STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts

Scientific ReportsJanuary 22, 2020
Maximilian N KinzlerSimone Fulda
Journal of Neurochemistry

Synucleinopathies: Where we are and where we need to go

Journal of NeurochemistryJanuary 21, 2020
Inês Caldeira BrásTiago Fleming Outeiro
10
Scientific Reports

Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons

Scientific ReportsJanuary 19, 2020
Carolina AlquezarAimee W Kao
7
Translational Research : the Journal of Laboratory and Clinical Medicine

Lithium treatment mitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signaling in mice

Translational Research : the Journal of Laboratory and Clinical MedicineJanuary 18, 2020
Mingxi LiHua Feng

See more papers from this feed

Related Feeds

AAV-based Gene Therapy

Adeno-associated virus (AAV)-based gene therapy is a biological vector that is being researched to be used as a potential therapeutic option. This gene therapy is designed to insert fragments of DNA into targeted cells to help treat diseases, such as hemophilia a. Discover the latest research on AAV-based gene therapy here.

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS - Phenotypes

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

© 2020 Meta ULC. All rights reserved
/feed-previews/neurodegeneration-genetics/943564d3-97cb-4a6e-8c78-f547229e8746