Neurodegeneration: Microglia & TDP-43

TDP-43 is implicated in several neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. It has also been shown to regulate microglial phagocytosis. Here is the latest research on the role of TDP-43 and microglia in neurodegeneration.

January 4, 2022

TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.

Journal of Medicinal Chemistry
Vanesa NozalAna Martinez
December 7, 2021
Review

Microglial TREM2 in amyotrophic lateral sclerosis.

Developmental Neurobiology
Manling XieLong-Jun Wu
December 1, 2021

Inflammasome activation in neurodegenerative diseases.

Essays in Biochemistry
Kishore Aravind Ravichandran, Michael T Heneka
November 28, 2021
Review
Open Access

Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia.

Cells
Simona Rossi, Mauro Cozzolino
November 28, 2021
Open Access

Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice.

International Journal of Molecular Sciences
Tamara JankovićKristina Pilipović
October 7, 2021
Preprint
Open Access

Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions

MedRxiv : the Preprint Server for Health Sciences
R. HasanT. Raj
September 27, 2021
Open Access

Age-at-Injury Determines the Extent of Long-Term Neuropathology and Microgliosis After a Diffuse Brain Injury in Male Rats.

Frontiers in Neurology
Yasmine V DoustJenna M Ziebell
September 24, 2021
Review

Glial TDP-43 and TDP-43 induced glial pathology, focus on neurodegenerative proteinopathy syndromes.

Glia
Katherine E PraterSuman Jayadev
July 29, 2021
Preprint
Open Access

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

BioRxiv : the Preprint Server for Biology
M. XieLong-Jun Wu
July 10, 2021
Preprint
Open Access

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology

BioRxiv : the Preprint Server for Biology
A. ReifschneiderChristian Haass
May 1, 2021
Review
Open Access

Progranulin in neurodegenerative dementia.

Journal of Neurochemistry
Xiao-Ming WangQing Tian
April 14, 2021
Preprint
Open Access

Joint ex vivo MRI and histology detect iron-rich cortical gliosis in Tau and TDP-43 proteinopathies

BioRxiv : the Preprint Server for Biology
M. Dylan TisdallD. J. Irwin
March 31, 2021

Targeting TDP-43 Pathology Alleviates Cognitive and Motor Deficits Caused by Chronic Cerebral Hypoperfusion.

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Sai Sampath ThammisettyJasna Kriz

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