Neurodegeneration: Microglia & TDP-43

TDP43 is is implicated in several neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. It has also been shown to regulate microglial phagocytosis. Here is the latest research on the role of TDP43 and microglia in neurodegeneration.

June 22, 2020

Combined 1-Deoxynojirimycin and Ibuprofen Treatment Decreases Microglial Activation, Phagocytosis and Dopaminergic Degeneration in MPTP-Treated Mice

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Tcs CostaM T Herrero
July 8, 2020

Neuropathological profile of long duration amyotrophic lateral sclerosis in military Veterans

Brain Pathology
Keith R SpencerThor D Stein
July 1, 2020

Chronic copper exposure directs microglia towards degenerative expression signatures in wild-type and J20 mouse model of Alzheimer's disease

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Siok Lam LimMasashi Kitazawa
July 1, 2020
Review

Dopamine: an immune transmitter

Neural Regeneration Research
Sarah Thomas BroomeAlessandro Castorina
June 25, 2020

Identification of Conserved Proteomic Networks in Neurodegenerative Dementia

Cell Reports
Vivek SwarupDaniel H Geschwind
June 21, 2020
Open Access

Apamin Suppresses LPS-Induced Neuroinflammatory Responses by Regulating SK Channels and TLR4-Mediated Signaling Pathways

International Journal of Molecular Sciences
Jihyun ParkKwan-Kyu Park
July 1, 2020
Open Access

HspB5 Activates a Neuroprotective Glial Cell Response in Experimental Tauopathy

Frontiers in Neuroscience
David W HamptonSiddarthan Chandran
June 26, 2020
Review
Open Access

The Role of P2X7 Receptor in Alzheimer's Disease

Frontiers in Molecular Neuroscience
Linda FrancistiováMiguel Díaz-Hernández
July 7, 2020
Open Access

Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington's Disease

Frontiers in Cellular Neuroscience
Anya KimManuel J Rodríguez
July 7, 2020
Review

ALS, a cellular whodunit on motor neuron degeneration

Molecular and Cellular Neurosciences
Peter Karagiannis, Haruhisa Inoue
June 20, 2020

Angiogenesis-Centered Molecular Cross-Talk in Amyotrophic Lateral Sclerosis Survival: Mechanistic Insights

Critical Reviews in Eukaryotic Gene Expression
Keshav ThakurAkshay Anand
July 5, 2020
Preprint
Open Access

A model of traumatic brain injury using human iPSC-derived cortical brain organoids

BioRxiv : the Preprint Server for Biology
J. D. LaiJustin Ichida
June 26, 2020
Open Access

Targeting Microglial Population Dynamics in Alzheimer's Disease: Are We Ready for a Potential Impact on Immune Function?

Frontiers in Cellular Neuroscience
Maria Martin-Estebane, Diego Gomez-Nicola

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