Neurodegeneration: Microglia & TDP-43

TDP-43 is implicated in several neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis and frontotemporal lobe dementia. It has also been shown to regulate microglial phagocytosis. Here is the latest research on the role of TDP-43 and microglia in neurodegeneration.

September 1, 2020

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.

Nature
Jiasheng ZhangEric J Huang
July 8, 2020

Neuropathological profile of long-duration amyotrophic lateral sclerosis in military Veterans

Brain Pathology
Keith R SpencerThor D Stein
January 17, 2017
Review
Open Access

M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b

Mediators of Inflammation
Chiara ParisiCinzia Volonté
July 4, 2017
Open Access

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Neuron
Rosa C PaolicelliLawrence Rajendran
September 21, 2018
Open Access

Subarachnoid hemorrhage enhances the expression of TDP-43 in the brain of experimental rats and human subjects

Experimental and Therapeutic Medicine
Tibiao HeFei Liu
February 22, 2018
Open Access

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

Nature Neuroscience
Krista J SpillerVirginia M-Y Lee
May 28, 2017
Case Report
Open Access

Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy

Journal of Alzheimer's Disease : JAD
Annachiara CagninSalvatore Monaco
July 10, 2018

FUS(1-359) transgenic mice as a model of ALS: pathophysiological and molecular aspects of the proteinopathy

Neurogenetics
Sergei Y FunikovAleksey A Ustyugov
September 28, 2020
Preprint
Open Access

Systemic Inflammation Causes Microglial Dysfunction With a Mixed Ad-like Pathology

ResearchSquare
Praveen Bathinilavinia Alberi
October 2, 2018
Open Access

Enteroviral Infection Leads to Transactive Response DNA-Binding Protein 43 Pathology in Vivo

The American Journal of Pathology
Yuan Chao XueHonglin Luo
October 10, 2019

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

Glia
Vandana DeoraTrent M Woodruff
November 1, 2018
Open Access

Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin

Molecular Neurobiology
Vincent Picher-MartelJean-Pierre Julien
July 15, 2017
Comment / Editorial

Neurodegenerative disease: Loss of TDP-43 in microglia - friend or foe?

Nature Reviews. Neurology
Charlotte Ridler
September 15, 2019
Review
Open Access

The endotoxin hypothesis of neurodegeneration

Journal of Neuroinflammation
Guy C Brown
November 1, 2019
Open Access

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

Journal of Neuroinflammation
Javier H JaraP Hande Özdinler
March 18, 2017
Case Report

Frontotemporal Dementia due to the Novel GRN Arg161GlyfsX36 Mutation

Journal of Alzheimer's Disease : JAD
Stefano GazzinaBarbara Borroni
August 27, 2019
Open Access

Microglia in frontotemporal lobar degeneration with progranulin or C9ORF72 mutations

Annals of Clinical and Translational Neurology
Nobutaka SakaeDennis Dickson
April 15, 2017
Open Access

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

Acta Neuropathologica
Martin H SchludiDieter Edbauer
November 11, 2018
Open Access

Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage

Journal of Neuroinflammation
Sai Sampath ThammisettyJasna Kriz

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