Neurodegeneration: Progranulin & Lipids

Progranulin is a secreted growth factor involved in inflammation, wound healing, cancer, and known for its neurotrophic properties. Along with lipids, these molcules are associated with neurodegenerative processes. Here are the latest discoveries pertaining to these molecules and neurodegeneration.

September 20, 2021

Molecular modeling and dynamics studies of the synthetic small molecule agonists with GPR17 and P2Y1 receptor.

Journal of Biomolecular Structure & Dynamics
Akshaya MurugesanKonda Mani Saravanan
September 20, 2021

Microsecond dynamics during the binding-induced folding of an intrinsically disordered protein.

Journal of Molecular Biology
Sreemantee SenJayant B Udgaonkar
September 18, 2021
Open Access

Niemann-Pick disease type C in Palestine: genotype and phenotype of sixteen patients and report of a novel mutation in the NPC1 gene.

BMC Medical Genomics
Imad DweikatAmeer Abo Mokh
September 17, 2021
Open Access

Retinal degeneration in mice and humans with neuronal ceroid lipofuscinosis type 8.

Annals of Translational Medicine
Elyse M SalpeterAla Moshiri
September 17, 2021

Network Inference of Transcriptional Regulation in Germinating Low Phytic Acid Soybean Seeds.

Frontiers in Plant Science
Lindsay C DeMersM A Saghai Maroof
September 17, 2021
Open Access

The Emerging Role of Neural Cell-Derived Exosomes in Intercellular Communication in Health and Neurodegenerative Diseases.

Frontiers in Neuroscience
Luyao HuoYong Xu
September 16, 2021

Ferroptosis and Liver Fibrosis.

International Journal of Medical Sciences
Qi PanKang He
September 15, 2021

Establishment of the vertebrate body plan: Rethinking gastrulation through stem cell models of early embryogenesis.

Developmental Cell
Benjamin SteventonAlfonso Martinez Arias
September 14, 2021

Increasing phagocytosis of micoglia by targeting CD33 with liposomes displaying glycan ligands.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Abhishek BhattacherjeeMatthew S Macauley
September 14, 2021

A nanophytosomes formulation based on elderberry anthocyanins and Codium lipids to mitigate mitochondrial dysfunctions.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Daniela MendesRomeu A Videira
September 14, 2021

Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders.

Acta Neuropathologica
Marzena Kurzawa-AkanbiChristopher M Morris
September 13, 2021

Synthetic probes and chemical tools in sphingolipid research.

Current Opinion in Chemical Biology
Jiyue Chen, Neal Devaraj

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