Neurodegenerative Disease: Genetics & Pathology

Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death, and leads to several diseases, including Alzheimer’s and Parkinson’s. This feed focuses on the genetics and pathology of neurodegenerative diseases.

January 16, 2022

Role of systems biology and multi-omics analyses in delineating spatial interconnectivity and temporal dynamicity of ER stress mediated cellular responses.

Biochimica Et Biophysica Acta. Molecular Cell Research
Priyanka MallickSaikat Chakrabarti
January 15, 2022
Open Access

Mitochondrial and redox modifications in early stages of Huntington disease

BioRxiv : the Preprint Server for Biology
C. LopesAna Cristina Rego
January 16, 2022

Increased Intrathecal B and Plasma Cells in Patients With Anti-IgLON5 Disease: A Case Series.

Neurology. Neuroimmunology and Neuroinflammation
Christine StrippelStjepana Kovac
January 15, 2022

Neuroimmunometabolism: A new pathological nexus underlying neurodegenerative disorders.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Swarup MitraShailesh N Khatri
January 15, 2022
Open Access

Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease.

Communications Biology
Gabriela NovakAlexander Skupin
January 15, 2022
Open Access

Rosiglitazone Ameliorates Spinal Cord Injury via Inhibiting Mitophagy and Inflammation of Neural Stem Cells.

Oxidative Medicine and Cellular Longevity
Qingqi MengHaifeng Zhang
January 15, 2022

Structural and functional neuroimaging of the effects of the gut microbiome.

European Radiology
Rodrigo A MontoroJohn-Paul J Yu
January 14, 2022

Body-first Parkinson's disease and variant Creutzfeldt-Jakob disease - similar or different?

Neurobiology of Disease
Amanda L Woerman, Gültekin Tamgüney
January 14, 2022

Puerarin action on stem cell proliferation, differentiation and apoptosis: Therapeutic implications for geriatric diseases.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Ruishuang MaYue Li
January 14, 2022

Skin Mirrors Brain: A Chance for Alzheimer's Disease Research.

Advances in Experimental Medicine and Biology
Christos C ZouboulisAmir M Hossini
January 14, 2022

Force Spectroscopy in Mechanical Protein Domains Unfolding.

Advances in Experimental Medicine and Biology
Dionysios G Cheirdaris
January 14, 2022

Genetic Pathways Involved in the Pathogenesis of Parkinson's Disease.

Advances in Experimental Medicine and Biology
Konstantina SkolarikiPanayiotis Vlamos
January 14, 2022

Biomarker-Driven Analysis Using High-Throughput Approaches in Neuroinflammation and Neurodegenerative Diseases.

Advances in Experimental Medicine and Biology
Marios G Krokidis

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TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS: Phenotypes

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Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS) is associated with the death of neurons that control voluntary muscles. This feed followes the latest research into therapies for this progressive neurodegenerative disease.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alexander Disease

Alexander disease is a rare leukodystrophy caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Here is the latest research on this disease.

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