Neurogenetics of Alternative Splicing

Alternative splicing is a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Dysregulation of alternative splicing can lead to developmental defects and can play a role in some neurological disorders. Here is that latest research.

February 20, 2021

Improving clinical interpretation of five KRIT1 and PDCD10 intronic variants.

Clinical Genetics
Carmela FuscoMarco Castori
February 7, 2021
Review
Open Access

Circular RNAs as Novel Regulators of β-Cell Functions under Physiological and Pathological Conditions.

International Journal of Molecular Sciences
Flora Brozzi, Romano Regazzi
February 6, 2021
Preprint
Open Access

NeuroSCORE: A Genome-wide Omics-Based Model to Identify Candidate Disease Genes of the Central Nervous System

BioRxiv : the Preprint Server for Biology
Kyle W. DavisM. Serrano
January 29, 2021

The conserved alternative splicing factor caper regulates neuromuscular phenotypes during development and aging.

Developmental Biology
M Brandon TitusEugenia C Olesnicky
January 19, 2021

Targeting RNA with small molecules: from fundamental principles towards the clinic.

Chemical Society Reviews
James P FaleseAmanda E Hargrove
January 12, 2021
Review
Open Access

Spinal Muscular Atrophy: In the Challenge Lies a Solution

Trends in Neurosciences
Brunhilde Wirth
January 3, 2021
Review

Hypoxia-induced alternative splicing in human diseases: the pledge, the turn, and the prestige

Cellular and Molecular Life Sciences : CMLS
Subhashis NatuaSanjeev Shukla
December 31, 2020
Open Access

Automated Isoform Diversity Detector (AIDD): a pipeline for investigating transcriptome diversity of RNA-seq data

BMC Bioinformatics
Noel-Marie PlonskiHelen Piontkivska
December 18, 2020
Open Access

ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell

Frontiers in Cellular and Infection Microbiology
Jie-Xi LiXing-Quan Zhu
December 11, 2020
Open Access

Staying true to yourself: mechanisms of DNA methylation maintenance in mammals

Nucleic Acids Research
Nataliya PetrykPierre-Antoine Defossez
November 27, 2020
Review
Open Access

Multiple functions of TBCK protein in neurodevelopment disorders and tumors

Oncology Letters
Jin Wu, Guanting Lu
November 6, 2020

Epitranscriptomic regulation of transcriptome plasticity in development and diseases of the brain

BMB Reports
Chan-Woo ParkKi-Jun Yoon
October 31, 2020
Open Access

P2X7 Receptor Upregulation in Huntington's Disease Brains

Frontiers in Molecular Neuroscience
Ivana OllàJosé J Lucas
October 21, 2020
Review

RNA processing in neurological tissue: development, aging and disease

Seminars in Cell & Developmental Biology
Ryan A SzetoCleber A Trujillo
October 15, 2020
Preprint
Open Access

Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex

BioRxiv : the Preprint Server for Biology
A. R. JeffriesJonathan Mill
October 14, 2020

Biallelic loss-of-function variants in NEMF cause central nervous system impairment and axonal polyneuropathy

Human Genetics
Ashfaque AhmedZhengmao Hu

Sign up to follow this feed and discover related papers.

Related Feeds

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Cognitive Decline: Environmental & Genetic Factors

This feed focuses on the role of environmental and genetic factors including environmental policies, disease susceptibility, and socioeconomic status on cognitive decline. Here is the latest research.

Epigenetic Changes in Pain

Targeted epigenetic interventions provide the tools to prevent nociceptive sensitization, mood-related symptoms, and other adaptations that occur in response to injury or inflammation, which will facilitate pain management and improve treatment efficacy in many chronic pain conditions. Here is the latest research on the epigenetics changes in pain.

Epigenetic Regulation of Microglia Functions

Microglial cells are instrumental in the maintenance of homeostasis in the CNS and can contribute to neurodegenerative disorders. Epigenetic mechanisms and transcriptional regulation may be potential therapeutic targets for their activation or suppression. Discover the latest research on epigenetic regulation of microglial functions here.

Gene-Environment Interaction & Behaviour

Gene-environment interaction is when two different genotypes respond to environmental variation in different ways.Genes and environment interact to form an individual's personality. Abnormal or extreme behaviour could thus be explained by hereditary factors in combination with poor environmental conditions.

Genetic Influences on Brain Development

The genetic landscape of an individual can have drastic effects on brain development and brain developmental disorders. Discover the latest research here.

Genetic Networks Underlying Habituation

Habituation, the gradual waning of an evoked behavioral response with repeated stimulation, is a basic and universal form of learning. This feed explores the genetic networks that are involved in the occurence of habituation.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Genetics of Pain

Subtle changes in DNA could partly explain the variation in individual differences in pain. There is growing evidence that a number of genes play a critical role in determining pain sensitivity, pain reporting and susceptibility to developing chronic pain and their response to surgical outcomes primarily, pain.

Immunogenetics of CNS Tumors

Central nervous system (CNS) tumors have a unique tumor immune microenvironment, where immune cells can play a role in disease progression and resistance to therapy. Studying the immunogenetics of these cells can uncover mechanisms underlying their role in CNS tumors. Here is the latest research.

© 2021 Meta ULC. All rights reserved
/feed-previews/neurogenetics-of-alternative-splicing/a04a09a6-8edf-4dae-b796-7ccd774ec5ea