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Neurotoxicity, Inflammation & Neuroprotection

Neurotoxicity, Inflammation & Neuroprotection diagram by nobeastsofierce, Shutterstock
nobeastsofierce, Shutterstock

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

Top 20 most recent papers

Cell-Surface Proteomic Profiling in the Fly Brain Uncovers Wiring Regulators

CellJanuary 21, 2020
Jiefu LiLiqun Luo
Nature Neuroscience

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Nature NeuroscienceJanuary 22, 2020
Julia MarschallingerTony Wyss-Coray

tec-1 kinase negatively regulates regenerative neurogenesis in planarians

ELifeJanuary 21, 2020
Alexander KargeChristian P Petersen
Nature Communications

JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells

Nature CommunicationsJanuary 22, 2020
Yongli ShanGuangjin Pan
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

Age-dependent remarkable regenerative potential of the dentate gyrus provided by intrinsic stem cells

The Journal of Neuroscience : the Official Journal of the Society for NeuroscienceJanuary 22, 2020
Tamar LichtEli Keshet
Scientific Reports

LRP-1 functionalized polymersomes enhance the efficacy of carnosine in experimental stroke

Scientific ReportsJanuary 22, 2020
Eun-Sun KimOk-Nam Bae

Astrocyte-T cell crosstalk regulates region-specific neuroinflammation

GliaJanuary 22, 2020
Jessica L WilliamsRobyn S Klein
Multiple Sclerosis : Clinical and Laboratory Research

Serum neurofilament light chain reflects inflammation-driven neurodegeneration and predicts delayed brain volume loss in early stage of multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory ResearchJanuary 22, 2020
Barbora SrpovaDana Horakova

Approaches to develop therapeutics to treat frontotemporal dementia

NeuropharmacologyJanuary 22, 2020
Lisa P EliaSteven Finkbeiner
Communications Biology

Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro

Communications BiologyJanuary 22, 2020
Gefei ChenJan Johansson
American Journal of Physiology. Endocrinology and Metabolism

The postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice

American Journal of Physiology. Endocrinology and MetabolismJanuary 22, 2020
Rui WuHang Shi
PloS One

Closed circuit xenon delivery for 72h in neonatal piglets following hypoxic insult using an ambient pressure automated control system: Development, technical evaluation and pulmonary effects

PloS OneJanuary 22, 2020
John DingleyEla Chakkarapani
The Lancet Child & Adolescent Health

Leptomeningeal malignancy of childhood: sharing learning between childhood leukaemia and brain tumour trials

The Lancet Child & Adolescent HealthJanuary 21, 2020
David A WalkerChristina Halsey
Annals of Clinical and Translational Neurology

CSF SerpinA1 in Creutzfeldt-Jakob disease and frontotemporal lobar degeneration

Annals of Clinical and Translational NeurologyJanuary 21, 2020
Samir Abu-RumeilehMarkus Otto
The Journal of Immunology : Official Journal of the American Association of Immunologists

An Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome: A Preliminary Report

The Journal of Immunology : Official Journal of the American Association of ImmunologistsJanuary 22, 2020
Grace E WeberLynn M Bekris
Frontiers in Aging Neuroscience

Peripheral Maintenance of the Axis SIRT1-SIRT3 at Youth Level May Contribute to Brain Resilience in Middle-Aged Amateur Rugby Players

Frontiers in Aging NeuroscienceJanuary 21, 2020
Rubén CorpasCoral Sanfeliu
Experimental Neurology

Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome

Experimental NeurologyJanuary 22, 2020
Ya-Chao WangWei Yang
Cellular and Molecular Life Sciences : CMLS

Deciphering the neuroprotective and neurogenic potential of soluble amyloid precursor protein alpha (sAPPα)

Cellular and Molecular Life Sciences : CMLSJanuary 22, 2020
Nawab John Dar, Gordon W Glazner
Biochemical and Biophysical Research Communications

The protective effect of polyethylene glycol-conjugated urokinase nanogels in rat models of ischemic stroke when administrated outside the usual time window

Biochemical and Biophysical Research CommunicationsJanuary 21, 2020
Wei CuiMaolin He
Journal of Neuroinflammation

MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammation

Journal of NeuroinflammationJanuary 22, 2020
Dongxu YueLin Xu

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