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Neutralizing Antibodies

Neutralizing Antibodies diagram by TimVickers , Wikimedia
TimVickers , Wikimedia

Neutralizing antibodies bind to their target an impair the biological activity of the target, rather than simply flagging the target for host leukocytes. This is an approach that is being used in vaccine development. Find the latest research on neutralizing antibodies here.

Top 20 most recent papers
bioRxiv

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers

bioRxivJanuary 19, 2020
Alexander A CohenPamela J Bjorkman
11
Vaccine

Thin silk fibroin films as a dried format for temperature stabilization of inactivated polio vaccine

VaccineJanuary 22, 2020
Jordan A StinsonKathryn M Kosuda
4
Vaccine

Activity of human serum antibodies in an influenza virus hemagglutinin stalk-based ADCC reporter assay correlates with activity in a CD107a degranulation assay

VaccineJanuary 22, 2020
Veronika ChromikovaFlorian Krammer
10
Molecular Therapy : the Journal of the American Society of Gene Therapy

AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer

Molecular Therapy : the Journal of the American Society of Gene TherapyJanuary 24, 2020
Helena Costa VerderaFederico Mingozzi
Journal of Virology

Novel transmitted/founder SHIVs for HIV latency and cure research

Journal of VirologyJanuary 24, 2020
Anya M BauerKatharine J Bar
Journal of Chromatography. a

Wayne State University experimental descriptor database for use with the solvation parameter model

Journal of Chromatography. aJanuary 20, 2020
Colin F Poole
Neural Regeneration Research

Neurotoxic role of interleukin-17 in neural stem cell differentiation after intracerebral hemorrhage

Neural Regeneration ResearchJanuary 22, 2020
Lu GaoHong-Wei Cheng
Journal of the American Academy of Dermatology

Buffered lidocaine 1%, epinephrine 1:100'000 with sodium bicarbonate (hydrogen carbonate) in a 3:1 ratio is less painful than a 9:1 ratio: A double-blind, randomized, placebo-controlled, crossover trial

Journal of the American Academy of DermatologyJanuary 21, 2020
Alexandra VentJürg Hafner
Journal of Autoimmunity

EZH2 deficiency attenuates Treg differentiation in rheumatoid arthritis

Journal of AutoimmunityJanuary 19, 2020
Xin-Yue XiaoXuan Zhang
1
Molecular Therapy. Methods & Clinical Development

Immune Response Mechanisms against AAV Vectors in Animal Models

Molecular Therapy. Methods & Clinical DevelopmentJanuary 24, 2020
Ashley T Martino, David M Markusic
Infection and Immunity

Nfa34810 facilitates Nocardia farcinica invasion of host cells and stimulates TNF-α secretion through activation of the NF-κB and MAPK pathways via TLR4

Infection and ImmunityJanuary 23, 2020
Xingzhao JiZhenjun Li
Human Vaccines & Immunotherapeutics

A novel ELISA for quantification of glycoprotein in human rabies vaccines using a clinically proven virus neutralizing human monoclonal antibody

Human Vaccines & ImmunotherapeuticsJanuary 24, 2020
Sunil GairolaSatish Waghmare
Chemosphere

A general linear free energy relationship for predicting partition coefficients of neutral organic compounds

ChemosphereJanuary 24, 2020
Deliang ChenYulan Fan
Journal of Animal Science

Corrigendum to: Evaluation of different inclusion levels of dry live yeast impacts on various rumen parameters and in situ digestibilities of dry matter and neutral detergent fiber in growing and finishing beef cattle

Journal of Animal ScienceJanuary 23, 2020
Caitlyn M CagleLuis O Tedeschi
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences

Cationic Nanoemulsions with Prolonged Retention Time as Promising Carriers for Ophthalmic Delivery of Tacrolimus

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical SciencesJanuary 21, 2020
Jialiang ZhangHongtao Song
Research in Veterinary Science

Comparative humoral immune response against cytopathic or non-cytopathic bovine viral diarrhea virus infection

Research in Veterinary ScienceJanuary 19, 2020
Mrigendra K S RajputChristopher C L Chase
Current Medicinal Chemistry

Monoclonal antibodies carried in drug delivery nanosystems as a strategy for cancer treatment

Current Medicinal ChemistryJanuary 23, 2020
Amanda Letícia Polli SilvestreMarlus Chorilli
Vaccine

Evaluation of Japanese encephalitis virus E and NS1 proteins immunogenicity using a recombinant Newcastle disease virus in mice

VaccineJanuary 21, 2020
Barnali NathSachin Kumar
2
International Journal of Biological Macromolecules

Macrophage-derived netrin-1 is critical for neuroangiogenesis in endometriosis

International Journal of Biological MacromoleculesJanuary 19, 2020
Xinyue GuoXinmei Zhang
Revue médicale suisse

Therapeutic innovations for hemophilia

Revue médicale suisseJanuary 22, 2020
Cedric Hermans, Catherine Lambert

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Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Antibody Development

Development of antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, and antibody cross-reactivity across species from the early stages of antibody development. Here is the latest research.


Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antibody synthesis

Antibodies have various functions including neutralization of pathogens, tumor targeting, as well as its utility in biomedical research. Here is the latest research on antibody synthesis.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

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