Neutralizing Antibodies

Neutralizing antibodies bind to their target an impair the biological activity of the target, rather than simply flagging the target for host leukocytes. This is an approach that is being used in vaccine development. Find the latest research on neutralizing antibodies here.

January 19, 2022

Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity.

Science Translational Medicine
Saborni ChakrabortyTaia T Wang
January 19, 2022

Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-elicited human sera.

Science
Alexander MuikUğur Şahin
January 18, 2022
Review

Neutralizing monoclonal antibodies against highly pathogenic coronaviruses.

Current Opinion in Virology
Rong XiangFei Yu
January 17, 2022
Preprint
Open Access

Real-world monitoring of BNT162b2 vaccine-induced SARS-CoV-2 B and T cell immunity in naive healthcare workers: a prospective single center study

MedRxiv : the Preprint Server for Health Sciences
B. CalcoenWim Maes
January 17, 2022

Drug discovery to treat COVID-19 two years after its outbreak.

Drug Discoveries & Therapeutics
Jianjun Gao, Fusheng Sun
January 17, 2022

Booster administration can make a difference in the antibody response to intradermal foot-and-mouth disease vaccination in cattle.

Archives of Virology
Can ÇokçalışkanErdoğan Asar
January 17, 2022

A quantitative assay for detection of SARS-CoV-2 neutralizing antibodies.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Helena CeruttiAlessandra Brogi
January 16, 2022
Preprint
Open Access

B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates

BioRxiv : the Preprint Server for Biology
M. A. HossainS. Munir Alam
January 16, 2022

Evaluation of ELISA and VNT for sheeppox virus antibody detection and development of an immunoenzymatic quantitative method.

Journal of Immunological Methods
Halima RhaziMehdi Elharrak
January 15, 2022
Preprint
Open Access

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance anti-HIV activity in vitro

BioRxiv : the Preprint Server for Biology
H. PanHuanzhang Zhu

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Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Antibody Development

Development of antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, and antibody cross-reactivity across species from the early stages of antibody development. Here is the latest research.


Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antibody synthesis

Antibodies have various functions including neutralization of pathogens, tumor targeting, as well as its utility in biomedical research. Here is the latest research on antibody synthesis.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

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