Next-Generation Therapeutics

Gene therapy and protein engineering strategies, guided by biological principles, are allowing ligands and receptors to be developed as next-generation therapeutics with improved safety and efficacy. Discover the latest research here.

April 22, 2020

Physicochemical determinants of antibody-protein interactions

Advances in Protein Chemistry and Structural Biology
Murat KaradagSibel Kalyoncu
June 5, 2020
Open Access

Harnessing Conformational Plasticity to Generate Designer Enzymes

Journal of the American Chemical Society
Rory M CreanShina C L Kamerlin
June 4, 2020

Target-mediated exposure enhancement: a previously unexplored limit of TMDD

Journal of Pharmacokinetics and Pharmacodynamics
Patrick M Glassman, Vladimir R Muzykantov
June 26, 2020
Review
Open Access

A Review of Landfill Microbiology and Ecology: A Call for Modernization With 'Next Generation' Technology

Frontiers in Microbiology
D'Arcy R Meyer-DombardJudy Malas
May 22, 2020
Open Access

HIV Is Associated with Modified Humoral Immune Responses in the Setting of HIV/TB Coinfection

MSphere
Esther van WoudenberghGalit Alter
April 26, 2020

Depression of Accumbal to Lateral Hypothalamic Synapses Gates Overeating

Neuron
Sarah ThoeniChristian Lüscher
April 22, 2020

The chiroptical response of aluminum nano-crescents at ultraviolet wavelengths

Nano Letters
Matthew S DavisAmit Agrawal
April 30, 2020

Precision medicine in clinical oncology: the journey from IgG antibody to IgE

Current Opinion in Allergy and Clinical Immunology
Judit Fazekas-SingerErika Jensen-Jarolim
July 1, 2020
Review
Open Access

Innovative Precision Gene-Editing Tools in Personalized Cancer Medicine

Advanced Science
Xiaofeng DaiKostya Ken Ostrikov
June 13, 2020
Review
Open Access

Extracellular Vesicles as Therapeutic Agents for Cardiac Fibrosis

Frontiers in Physiology
Russell G RogersAhmed G Ibrahim
June 10, 2020

An Effective Method for Quantifying RNA Expression of IbsC-SibC, a Type I Toxin-Antitoxin System in Escherichia coli

Chembiochem : a European Journal of Chemical Biology
Shahrzad Jahanshahi, Yingfu Li
May 25, 2020
Open Access

Research Techniques Made Simple: Whole-Transcriptome Sequencing by RNA-Seq for Diagnosis of Monogenic Disorders

The Journal of Investigative Dermatology
Amir Hossein SaeidianJouni Uitto
June 24, 2020
Review
Open Access

Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy

Cells
Jan A Rath, Caroline Arber
June 10, 2020
Review

The adenosine pathway in immuno-oncology

Nature Reviews. Clinical Oncology
Bertrand AllardJohn Stagg
July 7, 2020
Preprint
Open Access

KDS2010, a newly developed reversible MAO-B inhibitor, as an effective therapeutic candidate for Parkinson's disease

BioRxiv : the Preprint Server for Biology
M.-H. NamC. Justin Lee
June 26, 2020
Open Access

Metabolic Engineering Strategies in Diatoms Reveal Unique Phenotypes and Genetic Configurations With Implications for Algal Genetics and Synthetic Biology

Frontiers in Bioengineering and Biotechnology
Jestin GeorgeMichele Fabris
July 9, 2020
Open Access

Comprehensive Constitutional Genetic and Epigenetic Characterization of Lynch-Like Individuals

Cancers
Estela DámasoGabriel Capellá

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