NMDA antagonists: Antidepressant properties

Despite widely reported clinical and preclinical studies of rapid antidepressant actions of NMDA receptor antagonists, there has been very little work examining the effects of these drugs in stress models of depression that require chronic administration of antidepressants or the molecular mechanisms that could account for the rapid responses. Discover the latest research here.

December 22, 2020
Open Access

Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice

Neurobiology of Stress
Sarah J JeffersonBernhard Luscher
November 17, 2020

Ketamine, psilocybine, and rapid acting antidepressant: new promise for psychiatry?

L'Encéphale
H BottemanneP Fossati
December 24, 2020
Review
Open Access

The role of dissociation in ketamine's antidepressant effects

Nature Communications
Elizabeth D Ballard, Carlos A Zarate
January 17, 2021

Primary role for melatonin MT2 receptors in the regulation of anhedonia and circadian temperature rhythm

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Francisco Borja BellochRosa María Tordera
January 13, 2021
Open Access

Role of FMRP in rapid antidepressant effects and synapse regulation

Molecular Psychiatry
Chelcie F HeaneyKimberly F Raab-Graham
December 2, 2020

Copper and anti-anhedonic effect of ketamine in treatment-resistant depression

Medical Hypotheses
Jakub SłupskiMaria Gałuszko-Węgielnik
November 17, 2020

Transdermal delivery of breakthrough therapeutics for the management of treatment-resistant and post-partum depression

International Journal of Pharmaceutics
Sonalika A BhattaccharjeeAjay K Banga
January 16, 2021

Chronic lithium exposure attenuates ketamine-induced mania-like behavior and c-Fos expression in the forebrain of mice

Pharmacology, Biochemistry, and Behavior
Tian-Hao GaoTao Li
December 18, 2020

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

Chemical Communications : Chem Comm
Ansgar BokelVlada B Urlacher
December 22, 2020

Predicting and Managing Treatment Non-Response in Posttraumatic Stress Disorder

Current Treatment Options in Psychiatry
Gregory A FonzoAlba Lara
November 20, 2020

Influence of formulation and route of administration on ketamine's safety and tolerability: systematic review

European Journal of Clinical Pharmacology
Paul GlueNatalie J Medlicott
December 4, 2020

Modulation of the functional connectome in major depressive disorder by ketamine therapy

Psychological Medicine
Ashish K SahibKatherine L Narr
December 11, 2020
Review
Open Access

The Ketamine Antidepressant Story: New Insights

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Tahani K Alshammari
December 22, 2020
Open Access

The stress susceptibility factor FKBP51 controls S-ketamine-evoked release of mBDNF in the prefrontal cortex of mice

Neurobiology of Stress
Elmira AnderzhanovaNils C Gassen
December 12, 2020
Open Access

Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine

Translational Psychiatry
Mireia Tarrés-GatiusAnna Castañé
December 8, 2020
Preprint
Open Access

Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission from Depression

MedRxiv : the Preprint Server for Health Sciences
Vasileia Kotoula

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