NMDA antagonists: Antidepressant properties

Despite widely reported clinical and preclinical studies of rapid antidepressant actions of NMDA receptor antagonists, there has been very little work examining the effects of these drugs in stress models of depression that require chronic administration of antidepressants or the molecular mechanisms that could account for the rapid responses. Discover the latest research here.

January 17, 2022

Prophylactic efficacy of ketamine, but not the low-trapping NMDA receptor antagonist AZD6765, against stress-induced maladaptive behavior and 4E-BP1-related synaptic protein synthesis impairment.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Anderson CamargoAna Lúcia S Rodrigues
January 16, 2022

Analysis of recreational psychedelic substance use experiences classified by substance.

Adrian HaseGregor Hasler
January 15, 2022

A retrospective analysis of ketamine intravenous therapy for depression in real-world care settings.

Journal of Affective Disorders
L Alison McInnesBoris D Heifets
January 13, 2022

Acute effects of ketamine on the pregenual anterior cingulate: linking spontaneous activation, functional connectivity, and glutamate metabolism.

European Archives of Psychiatry and Clinical Neuroscience
Matti GärtnerSimone Grimm
January 13, 2022

Racemic Ketamine as an Alternative to Electroconvulsive Therapy for Unipolar Depression: A Randomized, Open-Label, Non-Inferiority Trial (KetECT).

The International Journal of Neuropsychopharmacology
Joakim EkstrandPouya Movahed Rad
January 12, 2022
Open Access

Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression.

Translational Psychiatry
Flurin CathomasJames W Murrough
January 11, 2022
Open Access

Experimenter sex modulates mouse biobehavioural and pharmacological responses

BioRxiv : the Preprint Server for Biology
P. GeorgiouTodd D Gould
January 11, 2022

Guanosine boosts the fast, but not sustained, antidepressant-like and pro-synaptogenic effects of ketamine by stimulating mTORC1-driven signaling pathway.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Anderson CamargoAna Lúcia S Rodrigues
January 8, 2022

A Novel Application of Ketamine for Improving Perioperative Sleep Disturbances.

Nature and Science of Sleep
Bijia Song, Junchao Zhu
January 7, 2022

[Pharmacology of ketamine and esketamine as rapid-acting antidepressants].

Psychiatrikē = Psychiatriki
Pavlina PavlidiChristina Dalla
January 7, 2022

[Clinical characteristics and treatment of treatment-resistant bipolar depression].

Psychiatrikē = Psychiatriki
Grigorios N KarakatsoulisKonstantinos N Fountoulakis
January 7, 2022

[Electroconvulsive therapy in treatment resistant depression: What is new?]

Psychiatrikē = Psychiatriki
Styliani C Kaliora
January 6, 2022

Increase in thalamic cerebral blood flow is associated with antidepressant effects of ketamine in major depressive disorder.

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Matti GärtnerSimone Grimm
January 1, 2022

The effect of intravenous ketamine on depressive symptoms after surgery: A systematic review.

Journal of Clinical Anesthesia
Jing WangChangwei Wei
January 1, 2022

Electrophysiological correlates and predictors of the antidepressant response to repeated ketamine infusions in treatment-resistant depression.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Sara de la SalleVerner Knott

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