NMDA antagonists: Antidepressant properties

Despite widely reported clinical and preclinical studies of rapid antidepressant actions of NMDA receptor antagonists, there has been very little work examining the effects of these drugs in stress models of depression that require chronic administration of antidepressants or the molecular mechanisms that could account for the rapid responses. Discover the latest research here.

December 22, 2020
Open Access

Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice

Neurobiology of Stress
Sarah J JeffersonBernhard Luscher
November 17, 2020

Ketamine, psilocybine, and rapid acting antidepressant: new promise for psychiatry?

H BottemanneP Fossati
December 24, 2020
Open Access

The role of dissociation in ketamine's antidepressant effects

Nature Communications
Elizabeth D Ballard, Carlos A Zarate
January 17, 2021

Primary role for melatonin MT2 receptors in the regulation of anhedonia and circadian temperature rhythm

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Francisco Borja BellochRosa María Tordera
January 13, 2021
Open Access

Role of FMRP in rapid antidepressant effects and synapse regulation

Molecular Psychiatry
Chelcie F HeaneyKimberly F Raab-Graham
December 2, 2020

Copper and anti-anhedonic effect of ketamine in treatment-resistant depression

Medical Hypotheses
Jakub SłupskiMaria Gałuszko-Węgielnik
November 17, 2020

Transdermal delivery of breakthrough therapeutics for the management of treatment-resistant and post-partum depression

International Journal of Pharmaceutics
Sonalika A BhattaccharjeeAjay K Banga
January 16, 2021

Chronic lithium exposure attenuates ketamine-induced mania-like behavior and c-Fos expression in the forebrain of mice

Pharmacology, Biochemistry, and Behavior
Tian-Hao GaoTao Li
December 18, 2020

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

Chemical Communications : Chem Comm
Ansgar BokelVlada B Urlacher
December 22, 2020

Predicting and Managing Treatment Non-Response in Posttraumatic Stress Disorder

Current Treatment Options in Psychiatry
Gregory A FonzoAlba Lara
November 20, 2020

Influence of formulation and route of administration on ketamine's safety and tolerability: systematic review

European Journal of Clinical Pharmacology
Paul GlueNatalie J Medlicott
December 4, 2020

Modulation of the functional connectome in major depressive disorder by ketamine therapy

Psychological Medicine
Ashish K SahibKatherine L Narr
December 11, 2020
Open Access

The Ketamine Antidepressant Story: New Insights

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Tahani K Alshammari
December 22, 2020
Open Access

The stress susceptibility factor FKBP51 controls S-ketamine-evoked release of mBDNF in the prefrontal cortex of mice

Neurobiology of Stress
Elmira AnderzhanovaNils C Gassen
December 12, 2020
Open Access

Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine

Translational Psychiatry
Mireia Tarrés-GatiusAnna Castañé
December 8, 2020
Open Access

Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission from Depression

MedRxiv : the Preprint Server for Health Sciences
Vasileia Kotoula

Sign up to follow this feed and discover related papers.

Related Feeds


This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Brain Circuits in Emotional Learning

The neuronal circuits within the cortico-limbic brain regions form networks that mediate emotional behavior. Areas specific to emotional learning include the basal amygdala and sublenticular extended amygdala region along with a supplemental motor area. Discover the latest research on brain circuits in emotional learning here.


Catatonia is a psychomotor syndrome with motor and behavioral symptoms, and can occur in both patients with or without psychiatric illness. Discover the latest research on Catatonia here.

Cognitive Behavioral Therapy

Cognitive behavioral therapy (CBT) is a psycho-social intervention that aims to improve mental health.CBT focuses on challenging and changing unhelpful cognitive distortions and behaviors, improving emotional regulation, and the development of personal coping strategies that target solving current problems. Discover the latest research on CBT here.

Collision Avoidance Behaviors

This feed focuses on collision avoidance behaviors including guiding locomotion, obstacle avoidance, and steering behaviour. Here is the latest research in this domain.

© 2021 Meta ULC. All rights reserved