NMDA antagonists: Antidepressant properties

Despite widely reported clinical and preclinical studies of rapid antidepressant actions of NMDA receptor antagonists, there has been very little work examining the effects of these drugs in stress models of depression that require chronic administration of antidepressants or the molecular mechanisms that could account for the rapid responses. Discover the latest research here.

January 17, 2022

Prophylactic efficacy of ketamine, but not the low-trapping NMDA receptor antagonist AZD6765, against stress-induced maladaptive behavior and 4E-BP1-related synaptic protein synthesis impairment.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Anderson CamargoAna Lúcia S Rodrigues
January 16, 2022

Analysis of recreational psychedelic substance use experiences classified by substance.

Psychopharmacology
Adrian HaseGregor Hasler
January 15, 2022

A retrospective analysis of ketamine intravenous therapy for depression in real-world care settings.

Journal of Affective Disorders
L Alison McInnesBoris D Heifets
January 13, 2022

Acute effects of ketamine on the pregenual anterior cingulate: linking spontaneous activation, functional connectivity, and glutamate metabolism.

European Archives of Psychiatry and Clinical Neuroscience
Matti GärtnerSimone Grimm
January 13, 2022

Racemic Ketamine as an Alternative to Electroconvulsive Therapy for Unipolar Depression: A Randomized, Open-Label, Non-Inferiority Trial (KetECT).

The International Journal of Neuropsychopharmacology
Joakim EkstrandPouya Movahed Rad
January 12, 2022
Open Access

Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression.

Translational Psychiatry
Flurin CathomasJames W Murrough
January 11, 2022
Preprint
Open Access

Experimenter sex modulates mouse biobehavioural and pharmacological responses

BioRxiv : the Preprint Server for Biology
P. GeorgiouTodd D Gould
January 11, 2022

Guanosine boosts the fast, but not sustained, antidepressant-like and pro-synaptogenic effects of ketamine by stimulating mTORC1-driven signaling pathway.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Anderson CamargoAna Lúcia S Rodrigues
January 8, 2022
Review

A Novel Application of Ketamine for Improving Perioperative Sleep Disturbances.

Nature and Science of Sleep
Bijia Song, Junchao Zhu
January 7, 2022
Review

[Pharmacology of ketamine and esketamine as rapid-acting antidepressants].

Psychiatrikē = Psychiatriki
Pavlina PavlidiChristina Dalla
January 7, 2022

[Clinical characteristics and treatment of treatment-resistant bipolar depression].

Psychiatrikē = Psychiatriki
Grigorios N KarakatsoulisKonstantinos N Fountoulakis
January 7, 2022

[Electroconvulsive therapy in treatment resistant depression: What is new?]

Psychiatrikē = Psychiatriki
Styliani C Kaliora
January 6, 2022

Increase in thalamic cerebral blood flow is associated with antidepressant effects of ketamine in major depressive disorder.

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Matti GärtnerSimone Grimm
January 1, 2022
Review

The effect of intravenous ketamine on depressive symptoms after surgery: A systematic review.

Journal of Clinical Anesthesia
Jing WangChangwei Wei
January 1, 2022

Electrophysiological correlates and predictors of the antidepressant response to repeated ketamine infusions in treatment-resistant depression.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Sara de la SalleVerner Knott

Sign up to follow this feed and discover related papers.

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Brain Circuits in Emotional Learning

The neuronal circuits within the cortico-limbic brain regions form networks that mediate emotional behavior. Areas specific to emotional learning include the basal amygdala and sublenticular extended amygdala region along with a supplemental motor area. Discover the latest research on brain circuits in emotional learning here.

Catatonia

Catatonia is a psychomotor syndrome with motor and behavioral symptoms, and can occur in both patients with or without psychiatric illness. Discover the latest research on Catatonia here.

Cognitive Behavioral Therapy

Cognitive behavioral therapy (CBT) is a psycho-social intervention that aims to improve mental health.CBT focuses on challenging and changing unhelpful cognitive distortions and behaviors, improving emotional regulation, and the development of personal coping strategies that target solving current problems. Discover the latest research on CBT here.

Collision Avoidance Behaviors

This feed focuses on collision avoidance behaviors including guiding locomotion, obstacle avoidance, and steering behaviour. Here is the latest research in this domain.

© 2022 Meta ULC. All rights reserved
/feed-previews/nmda-antagonists-antidepressant/434d3398-7759-4e04-abd2-aa6887173f5f