Non-coding Variants in Cancer

Mutations, single nucleotide variants and large genomic rearrangements, in non-coding regions of the genome can have severe consequences such as disruption of transcription factor binding sites and functions of non-coding RNAs and can impact tumor development and progression. Here is the latest research.

February 24, 2021
Open Access

Megabase-scale methylation phasing using nanopore long reads and NanoMethPhase.

Genome Biology
Vahid AkbariSteven J M Jones
February 24, 2021
Open Access

scSorter: assigning cells to known cell types according to marker genes.

Genome Biology
Hongyu Guo, Jun Li
February 24, 2021
Open Access

Structural mechanism of DNA recognition by the p204 HIN domain.

Nucleic Acids Research
Xiaojiao FanTengchuan Jin
February 24, 2021

Reprograming of sRNA target specificity by the leader peptide peTrpL in response to antibiotic exposure.

Nucleic Acids Research
Hendrik MeliorElena Evguenieva-Hackenberg
February 24, 2021
Open Access

Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation.

Nucleic Acids Research
H Helena WuRoger P Leng
February 24, 2021
Open Access

Sequence-independent RNA sensing and DNA targeting by a split domain CRISPR-Cas12a gRNA switch.

Nucleic Acids Research
Scott P CollinsChase L Beisel
February 24, 2021
Open Access

Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice.

Nucleic Acids Research
Ihsan DereliAttila Tóth
February 24, 2021

Accurate single-cell genotyping utilizing information from the local genome territory.

Nucleic Acids Research
Kailing TuDan Xie
February 24, 2021
Open Access

The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases.

Nucleic Acids Research
Gui-Xin PengXiao-Long Zhou
February 24, 2021
Open Access

Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis.

Nucleic Acids Research
Chengyong WuQiang Chen
February 24, 2021
Open Access

Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes.

Nucleic Acids Research
Qian-Qian ShaHeng-Yu Fan
February 24, 2021
Open Access

In vivo structure of the Ty1 retrotransposon RNA genome.

Nucleic Acids Research
Angelika AndrzejewskaKatarzyna Pachulska-Wieczorek
February 24, 2021

Intron exon boundary junctions in human genome have in-built unique structural and energetic signals.

Nucleic Acids Research
Akhilesh MishraB Jayaram
February 24, 2021
Open Access

Conserved dual-mode gene regulation programs in higher eukaryotes.

Nucleic Acids Research
Jun-Yeong LeeSamuel Beck
February 24, 2021
Open Access

Tandem RNA binding sites induce self-association of the stress granule marker protein TIA-1.

Nucleic Acids Research
Fionna E LoughlinJacqueline A Wilce
February 21, 2021
Comment / Editorial
Open Access

Promoting reproducibility with Code Ocean.

Genome Biology
Barbara Cheifet

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