Non-coding Variants in Cancer

Mutations, single nucleotide variants and large genomic rearrangements, in non-coding regions of the genome can have severe consequences such as disruption of transcription factor binding sites and functions of non-coding RNAs and can impact tumor development and progression. Here is the latest research.

July 2, 2020

MicroRNA dilution during oocyte growth disables the microRNA pathway in mammalian oocytes

Nucleic Acids Research
Shubhangini KatarukaPetr Svoboda
July 1, 2020
Open Access

A unified view of the sequence and functional organization of the human RNA polymerase II promoter

Nucleic Acids Research
Donal S LuseDavid H Price
July 2, 2020

The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27

Nucleic Acids Research
Nicolas Lemus-DiazMarkus T Bohnsack
July 4, 2020

Spatial genome architecture and the emergence of malignancy

Human Molecular Genetics
Adi Danieli, Argyris Papantonis
July 2, 2020

DSS1 and ssDNA regulate oligomerization of BRCA2

Nucleic Acids Research
Hang Phuong LeJie Liu
July 3, 2020

Poly(A) binding KPAF4/5 complex stabilizes kinetoplast mRNAs in Trypanosoma brucei

Nucleic Acids Research
Inna AphasizhevaRuslan Aphasizhev
July 1, 2020

Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition

Nucleic Acids Research
Alexander S Thuy-BounPeter A Beal
July 6, 2020

CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex

Nucleic Acids Research
Jennifer V GerbrachtNiels H Gehring
July 6, 2020

Quantile normalization of single-cell RNA-seq read counts without unique molecular identifiers

Genome Biology
F William Townes, Rafael A Irizarry
July 1, 2020

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

Nucleic Acids Research
Sherine E ThomasVítor Mendes
July 4, 2020

Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

Nucleic Acids Research
Laura Escoter-TorresNina Henriette Uhlenhaut

Sign up to follow this feed and discover related papers.

Related Feeds

AAV-based Gene Therapy

Adeno-associated virus (AAV)-based gene therapy is a biological vector that is being researched to be used as a potential therapeutic option. This gene therapy is designed to insert fragments of DNA into targeted cells to help treat diseases, such as hemophilia a. Discover the latest research on AAV-based gene therapy here.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Acute Myeloid Leukaemia & RNA

Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Alzheimer's Disease: Genetics

Alzheimer's disease is a chronic neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations here.

Alzheimer's Disease: RNA Sequencing

RNA sequencing is used to reveal the presence and quantity of RNA in a given sample. In this feed, RNA sequencing investigates the genetic and molecular mechanisms related to the pathophysiology of Alzheimer's disease (AD). Here are the latest discoveries pertaining to RNA sequencing and this disease.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Breast Cancer: Risk Factors

Breast cancer is a multifactorial disease that is influenced by both environmental and genetic factors. Discover the latest research on the environmental and genetic risk factors for breast cancer here.

© 2020 Meta ULC. All rights reserved
/feed-previews/non-coding-variants-in-cancer/21a1e743-ffa9-42d4-a082-fb853d2acccd