Non-coding Variants in Cancer

Mutations, single nucleotide variants and large genomic rearrangements, in non-coding regions of the genome can have severe consequences such as disruption of transcription factor binding sites and functions of non-coding RNAs and can impact tumor development and progression. Here is the latest research.

July 2, 2020

MicroRNA dilution during oocyte growth disables the microRNA pathway in mammalian oocytes

Nucleic Acids Research
Shubhangini KatarukaPetr Svoboda
July 1, 2020
Open Access

A unified view of the sequence and functional organization of the human RNA polymerase II promoter

Nucleic Acids Research
Donal S LuseDavid H Price
July 2, 2020

The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27

Nucleic Acids Research
Nicolas Lemus-DiazMarkus T Bohnsack
July 4, 2020

Spatial genome architecture and the emergence of malignancy

Human Molecular Genetics
Adi Danieli, Argyris Papantonis
July 2, 2020

DSS1 and ssDNA regulate oligomerization of BRCA2

Nucleic Acids Research
Hang Phuong LeJie Liu
July 3, 2020

Poly(A) binding KPAF4/5 complex stabilizes kinetoplast mRNAs in Trypanosoma brucei

Nucleic Acids Research
Inna AphasizhevaRuslan Aphasizhev
July 1, 2020

Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition

Nucleic Acids Research
Alexander S Thuy-BounPeter A Beal
July 6, 2020

CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex

Nucleic Acids Research
Jennifer V GerbrachtNiels H Gehring
July 6, 2020

Quantile normalization of single-cell RNA-seq read counts without unique molecular identifiers

Genome Biology
F William Townes, Rafael A Irizarry
July 1, 2020

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

Nucleic Acids Research
Sherine E ThomasVítor Mendes
July 4, 2020

Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

Nucleic Acids Research
Laura Escoter-TorresNina Henriette Uhlenhaut

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