Organelles in Neurodegeneration

Each cellular organelle plays a specific role in keeping a cell healthy. Different organelles, such as lysosomes and mitochondria, are implicated in neurodegenerative diseases. This feed focuses on cellular organelles and their role in neurodegeneration.

October 17, 2021

Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson's disease.

Neuropharmacology
Mir Hilal AhmadAmal Chandra Mondal
October 15, 2021

Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration.

ACS Chemical Neuroscience
A Katherine HatstatDewey G McCafferty
October 15, 2021
Open Access

Interruption of Endolysosomal Trafficking After Focal Brain Ischemia.

Frontiers in Molecular Neuroscience
Kurt HuBingren Hu
October 15, 2021

The Sigma-1 receptor is an ER-localized type II membrane protein.

The Journal of Biological Chemistry
Neeraj SharmaGerardo Z Lederkremer
October 13, 2021
Open Access

Drosophila Rab39 Attenuates Lysosomal Degradation.

International Journal of Molecular Sciences
Zsolt LakatosPéter Lőrincz
October 13, 2021
Open Access

Dynamic Changes of Brain Cilia Transcriptomes across the Human Lifespan.

International Journal of Molecular Sciences
Siwei ChenAmal Alachkar
October 13, 2021
Review
Open Access

Impaired Mitophagy in Neurons and Glial Cells during Aging and Age-Related Disorders.

International Journal of Molecular Sciences
Vladimir SukhorukovSergey Illarioshkin
October 11, 2021
Review

Recent advances in understanding the role of proteostasis.

Faculty Reviews
Kanika VermaKausik Chakraborty
October 11, 2021
Open Access

Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations.

Frontiers in Cell and Developmental Biology
Anbin ChenKristina Xiao Liang
October 11, 2021

Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington's Disease.

Aging and Disease
Emily MachielaJeremy M Van Raamsdonk
October 11, 2021

Chaperone-mediated autophagy and disease: Implications for cancer and neurodegeneration.

Molecular Aspects of Medicine
Raquel Gómez-Sintes, Esperanza Arias
October 11, 2021

Clinical, imaging, biochemical and molecular features in Leigh syndrome: a study from the Italian network of mitochondrial diseases.

Orphanet Journal of Rare Diseases
Anna ArdissoneIsabella Moroni
October 10, 2021
Review

Molecular chaperones and Parkinson's disease.

Neurobiology of Disease
Shenglan HuChunyu Wang
October 9, 2021

Labeling and Measuring Stressed Mitochondria Using a PINK1-Based Ratiometric Fluorescent Sensor.

The Journal of Biological Chemistry
Rie UesugiEisuke Itakura
October 7, 2021

Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer's disease.

Journal of Pineal Research
Chongyang ChenGong-Ping Liu
October 4, 2021

The deubiquitinase USP11 is a versatile and conserved regulator of autophagy.

The Journal of Biological Chemistry
Mila BasicAnja Bremm
October 1, 2021
Review

Role of chaperone-mediated autophagy in the pathophysiology including pulmonary disorders.

Inflammation and Regeneration
Yusuke HosakaKazuyoshi Kuwano
October 1, 2021
Open Access

A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1.

BMC Biology
Anika V PrabhuForbes D Porter

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