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Organoids & Neurodegeneration

Organoids & Neurodegeneration diagram by undefined

Recently, cerebral organoids derived from induced pluripotent stem (ips) cells have illuminated early developmental events altered by disease processes, and may be a promising avenue for future therapies in neurodegenerative disorders. Here is the latest research on Organoids & Neurodegeneration.

Top 20 most recent papers
bioRxiv

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

bioRxivNovember 25, 2019
Seiko IkezuTsuneya Ikezu
3
bioRxiv

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

bioRxivNovember 26, 2019
Didier TronoVolker Busskamp
11
Nature Genetics

Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells

Nature GeneticsNovember 20, 2019
Angels Almenar-QueraltIvan Garcia-Bassets
34
1
bioRxiv

Effect of sinusoidal electrical cortical stimulation on brain cells

bioRxivNovember 26, 2019
Seungjun RyuHyoung-Ihl Kim
2
bioRxiv

Human-specific regulatory features of brain development manifest staggering breadth of associations with physiological processes and pathological conditions of H. sapiens

bioRxivNovember 20, 2019
Gennadi V Glinsky
3
Scientific Reports

Sonic Hedgehog is expressed by hilar mossy cells and regulates cellular survival and neurogenesis in the adult hippocampus

Scientific ReportsNovember 22, 2019
Luis E Gonzalez-ReyesDominique M Durand
4
bioRxiv

A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol

bioRxivNovember 17, 2019
Christoph GerdesFelipe Opazo
23
Nano Letters

Dihydrolipoic Acid-Gold Nanoclusters Regulate Microglial Polarization and Have the Potential To Alter Neurogenesis

Nano LettersDecember 4, 2019
Lan XiaoYin Xiao
bioRxiv

Expanded huntingtin CAG repeats disrupt the balance between neural progenitor expansion and differentiation in human cerebral organoids

bioRxivNovember 26, 2019
Jinqiu ZhangMahmoud A. Pouladi
6
Scientific Reports

Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures

Scientific ReportsNovember 20, 2019
Tanja HyvärinenSusanna Narkilahti
Scientific Reports

Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone

Scientific ReportsNovember 28, 2019
Rita MattaAnjelica L Gonzalez
2
1
Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging

In vivo Cell Tracking Using Non-invasive Imaging of Iron Oxide-Based Particles with Particular Relevance for Stem Cell-Based Treatments of Neurological and Cardiac Disease

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular ImagingDecember 4, 2019
Joel Clinton GloverEU COST Action 16122 (BIONECA)
Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology

Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune PharmacologyDecember 4, 2019
Marina V AksenovaMichael S Shtutman
1
Brain Research

Reverse Engineering Human Brain Evolution Using Organoid Models

Brain ResearchDecember 3, 2019
Mohammed A Mostajo-RadjiAlex A. Pollen
The International Journal of Neuroscience

The effects of minocycline on proliferation, differentiation and migration of neural stem/progenitor cells

The International Journal of NeuroscienceDecember 5, 2019
Fatemeh ShamsiHadi Aligholi
Journal of the Mechanical Behavior of Biomedical Materials

Articulation of an alumina-zirconia composite ceramic against living cartilage - An in vitro wear test

Journal of the Mechanical Behavior of Biomedical MaterialsNovember 11, 2019
Markus A WimmerSusan Chubinskaya
ELife

Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex

ELifeDecember 3, 2019
Raphael M BendriemM Elizabeth Ross
7
Neural Plasticity

Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials

Neural PlasticityOctober 16, 2019
Gengmei XingRenjie Chai
Journal of Neuroinflammation

Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons

Journal of NeuroinflammationNovember 18, 2019
Clayton W WinklerKarin E Peterson
6
5
ELife

Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control

ELifeNovember 29, 2019
Swagata GhatakStuart A. Lipton
5
1

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