Organoids & Neurodegeneration

Cerebral organoids derived from induced pluripotent stem (IPS) cells have illuminated early developmental events altered by disease processes, and may be a promising avenue for future therapies in neurodegenerative disorders. Here is the latest research on organoids and neurodegeneration.

February 24, 2021
Open Access

Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids.

Biology Open
Roberta AzzarelliBenjamin D Simons
February 24, 2021

Long-term maturation of human cortical organoids matches key early postnatal transitions.

Nature Neuroscience
Aaron GordonDaniel H Geschwind
February 24, 2021

STRADA-mutant human cortical organoids model megalencephaly and exhibit delayed neuronal differentiation.

Developmental Neurobiology
Louis T DangJack M Parent
February 23, 2021
Preprint
Open Access

Oncogenic BRAF V600E induces glial proliferation through ERK and neuronal death through JNK

ResearchSquare
Qing YeXiqun Chen
February 23, 2021
Review
Open Access

Organoid Models of Glioblastoma and Their Role in Drug Discovery.

Frontiers in Cellular Neuroscience
Matthew J RybinZane Zeier
February 23, 2021
Open Access

Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning.

PLoS Computational Biology
Philipp MergenthalerDavid W Andrews
February 20, 2021

Better understanding the neurobiology of primary lateral sclerosis.

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
P Hande OzdinlerGeorg Haase
February 19, 2021
Open Access

Mass Generation, Neuron Labeling, and 3D Imaging of Minibrains.

Frontiers in Bioengineering and Biotechnology
Subashika GovindanAdrien Roux
February 19, 2021
Review
Open Access

Functional patient-derived cellular models for neuropsychiatric drug discovery.

Translational Psychiatry
Santiago G LagoSabine Bahn
February 18, 2021
Open Access

A Human 3D neural assembloid model for SARS-CoV-2 infection.

Research Square
Joseph GleesonAaron Carlin
February 18, 2021
Preprint
Open Access

A Human 3D neural assembloid model for SARS-CoV-2 infection.

BioRxiv : the Preprint Server for Biology
Lu WangJoseph Gleeson
February 17, 2021

Stem cells basedin vitromodels: Trends and prospects in biomaterials cytotoxicity studies.

Biomedical Materials
Uzair AhmedAnwarul Hasan
February 16, 2021
Review

Human Induced Pluripotent Stem Cells and CRISPR/Cas-Mediated Targeted Genome Editing: Platforms to Tackle Sensorineural Hearing Loss.

Stem Cells
Miodrag StojkovicKonstantina M Stankovic
February 16, 2021
Review
Open Access

Evolution of Experimental Models in the Study of Glioblastoma: Toward Finding Efficient Treatments.

Frontiers in Oncology
Ricardo Gómez-OlivaNoelia Geribaldi-Doldán
February 13, 2021
Review
Open Access

Immunotherapy of Glioblastoma: Current Strategies and Challenges in Tumor Model Development.

Cells
Bernarda MajcBarbara Breznik
February 12, 2021
Preprint
Open Access

A Human 3D neural assembloid model for SARS-CoV-2 infection

ResearchSquare
Joseph GleesonAaron Carlin
February 10, 2021

Human heart-forming organoids recapitulate early heart and foregut development.

Nature Biotechnology
Lika DrakhlisRobert Zweigerdt
February 9, 2021
Preprint
Open Access

A Human 3D neural assembloid model for SARS-CoV-2 infection

BioRxiv : the Preprint Server for Biology
Joseph G GleesonA. E. Clark

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