Oxygenation & Hydroxylation

Oxygenation is a chemical production that introduces oxygen atom into an organic compound. Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Cytochrome P450 (CYP) enzymes are expressed mainly in the liver and are active in mono-oxygenation and hydroxylation of various xenobiotics, including drugs and alcohols, as well as that of endogenous compounds such as steroids, bile acids, prostaglandins, leukotrienes and biogenic amines. Here is the latest research.

July 8, 2020

Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry
Thomas S CorriganÖzlem Doğan Ekici
July 7, 2020

Heparanase-enhanced Shedding of Syndecan-1 and Its Role in Driving Disease Pathogenesis and Progression

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Sunil RangarajanRalph D Sanderson
July 8, 2020

A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Aline Dias de AlmeidaAndré Klein
July 8, 2020

Flipped regiospecificity in L434F mutant of 8-lipoxygenase

Physical Chemistry Chemical Physics : PCCP
Vipin Kumar Mishra, Sabyashachi Mishra
July 8, 2020

EEG features of brain injury during extracorporeal membrane oxygenation in children

Neurology
Arnold J SansevereRobert C Tasker
July 8, 2020

Fatigue Increases in Resting Muscle Oxygen Consumption after a Women's Soccer Match

International Journal of Sports Medicine
Aldo Alfonso Vasquez BonillaGuillermo Olcina
July 8, 2020

Methanol production by Methylacidiphilum fumariolicum SolV under different growth conditions

Applied and Environmental Microbiology
Carmen HogendoornHuub J M Op den Camp
July 8, 2020

Cerebral Dopamine Neurotrophic Factor regulates multiple neuronal subtypes and behavior

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Yu-Chia ChenPertti Panula
July 8, 2020

Biochemical Toxicity and Potential Detoxification Mechanisms in Earthworms Eisenia fetida Exposed to Sulfamethazine and Copper

Bulletin of Environmental Contamination and Toxicology
Hong RongJinyu Yu
July 8, 2020

Selective Chemonucleolysis With Condoliase in Cynomolgus Monkeys

Toxicologic Pathology
Dai MuramatsuAisuke Nii
July 8, 2020

Water Bridges Play a Key Role in the Affinity and Selectivity for the Malarial Protease Falcipain-2

Journal of Chemical Information and Modeling
Jorge Enrique Hernandez GonzalezPedro Geraldo Pascutti

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