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P2Y12 & Microglial Self-Renewal

P2Y12 & Microglial Self-Renewal diagram by Public Domain, Wikimedia
Public Domain, Wikimedia

P2Y12 is a G-coupled receptor that is known for its role in platelet activation. However, the expression and involvement in the CNS and microglial activation and renewal is less known. Discover the latest research on P2Y12 and microglial self-renewal here.

Top 20 most recent papers
Nature Reviews. Neurology

The pro-remyelination properties of microglia in the central nervous system

Nature Reviews. NeurologyJuly 1, 2019
Amy F Lloyd, Veronique E Miron
78
1
140
Proceedings of the National Academy of Sciences of the United States of America

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination

Proceedings of the National Academy of Sciences of the United States of AmericaNovember 20, 2019
Christopher E McMurranRobin J M Franklin
19
16
The Journal of Experimental Medicine

Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

The Journal of Experimental MedicineFebruary 21, 2020
Maria Inês CunhaMikael Simons
20
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections

The Journal of Neuroscience : the Official Journal of the Society for NeuroscienceOctober 11, 2019
Mingshu MoLong-Jun Wu
26
17
Neurochemistry International

Noradrenaline is crucial for the substantia nigra dopaminergic cell maintenance

Neurochemistry InternationalSeptember 23, 2019
Sara Af BjerkénIngrid Strömberg
2
9
Neuroscience Letters

Astrocytes in myelination and remyelination

Neuroscience LettersOctober 8, 2019
Irene Molina-Gonzalez, Veronique E Miron
18
21
Molecular and Cellular Neurosciences

Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses

Molecular and Cellular NeurosciencesNovember 27, 2019
Jennifer J O'BrienJoseph P Hendrick
5
Frontiers in Molecular Neuroscience

Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells

Frontiers in Molecular NeuroscienceOctober 17, 2019
Charbel S BaakliniJason R Plemel
26
38
European Journal of Immunology

Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor

European Journal of ImmunologySeptember 25, 2019
Tomonori SuzukiHiroshi Sakuma
2
4
Methods in Molecular Biology

Measuring Microglial Turnover in the Adult Brain

Methods in Molecular BiologyAugust 9, 2019
Diego Gomez-NicolaKatharine E Askew
10
1

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