Parkinson's Disease: Alpha-Synuclein

Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research.

September 2, 2020
Open Access

Defining an amyloid link Between Parkinson's disease and melanoma

Proceedings of the National Academy of Sciences of the United States of America
Dexter N Dean, Jennifer C Lee
September 2, 2020
Open Access

Transgenic mice expressing human alpha-synuclein in noradrenergic neurons develop locus coeruleus pathology and non-motor features of Parkinson's disease

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Laura M ButkovichMalú Gámez Tansey
September 5, 2020
Open Access

Molecular basis for N-terminal alpha-synuclein acetylation by human NatB

ELife
Sunbin DengRonen Marmorstein
September 15, 2020

Perturbation of in vivo Neural Activity Following α-Synuclein Seeding in the Olfactory Bulb

Journal of Parkinson's Disease
Aishwarya S KulkarniDaniel W Wesson
September 6, 2020

Reduction of Lewy Body Pathology by Oral Cinnamon

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Sumita RahaKalipada Pahan
September 15, 2020

Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease

Journal of Parkinson's Disease
Christine L WestWolfgang A Kunze
September 15, 2020
Open Access

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease

Journal of Enzyme Inhibition and Medicinal Chemistry
Serena VittorioLaura De Luca
September 8, 2020

Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1

Molecular Neurobiology
Shruti SharmaRakesh Pandey
September 16, 2020

Changes in the cellular fatty acid profile drive the proteasomal degradation of α-synuclein and enhance neuronal survival

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Mary XylakiEvangelia Emmanouilidou
September 15, 2020

Alpha-Synuclein Aggregates Associated with Mitochondria in Tunnelling Nanotubes

Neurotoxicity Research
Dario ValdinocciDean L Pountney
September 5, 2020

Effects of Subthalamic Deep Brain Stimulation With Different Frequencies in a Parkinsonian Rat Model

Neuromodulation : Journal of the International Neuromodulation Society
Zhimin LiRenzhi Wang
September 18, 2020

Gut microbiota dynamics in Parkinsonian mice

ACS Chemical Neuroscience
Emily KlannVinata Vedam-Mai
September 15, 2020

Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer's Disease and Related Neurological Disorders

Journal of Alzheimer's Disease : JAD
Matthew John MoldChristopher Exley
September 11, 2020
Open Access

Immunotherapies Targeting α-Synuclein in Parkinson Disease

Federal Practitioner : for the Health Care Professionals of the VA, DoD, and PHS
Fariha Jamal

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