Parkinson's Disease: Alpha-Synuclein

Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on alpha-synuclein and Parkinson's disease.

April 18, 2021

NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.

Molecular Medicine Reports
Hua GaoXinling Yang
April 18, 2021
Review

Natural antioxidants in the management of Parkinson's disease: Review of evidence from cell line and animal models.

Journal of Integrative Medicine
Reem Abdul-LatifThilini Thrimawithana
April 17, 2021

An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3.

The Journal of Biological Chemistry
Naoya FukuiYasushi Kawata
April 16, 2021

The gut-brain axis and Parkinson disease: clinical and pathogenetic relevance.

Annals of Medicine
Elisa MenozziAnthony H V Schapira
April 16, 2021
Review

Parkinson's Disease and the Gut: Models of an Emerging Relationship.

Acta Biomaterialia
Adam J BindasAbigail N Koppes
April 15, 2021
Preprint
Open Access

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

BioRxiv : the Preprint Server for Biology
A. DelaidelliAsad Jan
April 15, 2021
Preprint
Open Access

A Phase II study to evaluate the safety and efficacy of prasinezumab in early Parkinson's disease (PASADENA): rationale, design and baseline data

MedRxiv : the Preprint Server for Health Sciences
Gennaro PaganoA. Bonni
April 16, 2021

Speech biomarkers in rapid eye movement sleep behaviour disorder and Parkinson's disease.

Annals of Neurology
Jan RuszKarel Šonka
April 16, 2021

The role of gut dysbiosis in Parkinson's disease: mechanistic insights andtherapeutic options.

Brain : a Journal of Neurology
Qing WangSven Pettersson
April 16, 2021

Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder.

Brain : a Journal of Neurology
Ambra StefaniSINBAR (Sleep Innsbruck Barcelona) group
April 16, 2021
Review
Open Access

Molecular Factors Mediating Neural Cell Plasticity Changes in Dementia Brain Diseases.

Neural Plasticity
Wojciech KozubskiJolanta Dorszewska
April 16, 2021
Open Access

Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy.

Acta Neuropathologica Communications
Lisa MészárosJürgen Winkler
April 14, 2021

Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation.

EMBO Molecular Medicine
Reini E N van der WelleJudith Klumperman
April 14, 2021
Case Report

Coexistence of dentatorubral-pallidoluysian atrophy and Parkinson's disease: An autopsy case report.

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Seong-Ik KimSung-Hye Park
April 14, 2021
Review
Open Access

Synucleinopathy-associated pathogenesis in Parkinson's disease and the potential for brain-derived neurotrophic factor.

NPJ Parkinson's Disease
Kathryn M MillerCaryl E Sortwell
April 14, 2021
Open Access

The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease.

Scientific Reports
Rachel M McQuadeShanti Diwakarla
April 12, 2021
Preprint
Open Access

Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy

BioRxiv : the Preprint Server for Biology
N.-V. MohamedThomas M. Durcan
April 12, 2021
Preprint
Open Access

Interactions between SARS-CoV-2 N-protein and α-synuclein accelerate amyloid formation

BioRxiv : the Preprint Server for Biology
S. SemerdzhievMireille M.A.E. Claessens
April 12, 2021
Open Access

Fatty Acid-Binding Protein 3 Expression in the Brain and Skin in Human Synucleinopathies.

Frontiers in Aging Neuroscience
Hideki OizumiAtsushi Takeda

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