Parkinson's Disease: LRRK2

Parkinson’s disease (PD) is a neurodegenerative disorder that affects movement. This feed focuses on leucine-rich repeat kinase 2 (LRRK2) which is the most prominent genetic contributor to PD.

December 4, 2020
Review
Open Access

Pathological Functions of LRRK2 in Parkinson's Disease

Cells
Ga Ram Jeong, Byoung Dae Lee
November 20, 2020
Review

Proteomic Complexity in Parkinson's Disease: A Redox Signaling Perspective of the Pathophysiology and Progression

Neuroscience
Marcos Martinez-Banaclocha
December 17, 2020
Open Access

NEAT1 on the Field of Parkinson's Disease: Offense, Defense, or a Player on the Bench?

Journal of Parkinson's Disease
Fanni Annamária BorosPéter Klivényi
November 23, 2020
Preprint
Open Access

Development of a multiplexed targeted mass spectrometry assay for LRRK2 phosphorylated Rabs and Ser910/Ser935 biomarker sites

BioRxiv : the Preprint Server for Biology
Raja S NirujogiDario R Alessi
December 21, 2020

Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study

Lancet Neurology
Edwin JabbariPSP Genetics Group
January 4, 2021

Biochemical markers for severity and risk in GBA and LRRK2 Parkinson's disease

Journal of Neurology
Avner ThalerAnat Mirelman
November 25, 2020
Preprint
Open Access

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

BioRxiv : the Preprint Server for Biology
A. U. MalikDario R Alessi
December 22, 2020
Case Report
Open Access

A Specific Diplotype H1j/H2 of the MAPT Gene Could Be Responsible for Parkinson's Disease with Dementia

Case Reports in Genetics
Imane SmailiAhmed Bouhouche
November 3, 2020
Preprint
Open Access

The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease

BioRxiv : the Preprint Server for Biology
S. L. CastroBriana R De Miranda
December 15, 2020
Open Access

The Rostock International Parkinson's Disease (ROPAD) Study: Protocol and Initial Findings

Movement Disorders : Official Journal of the Movement Disorder Society
Volha SkrahinaROPAD Study Group
October 31, 2020
Open Access

Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery

Frontiers in Molecular Neuroscience
Susan S TaylorFriedrich W Herberg
December 11, 2020
Open Access

Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease

NPJ Parkinson's Disease
Meghan L BucherTeresa G Hastings
November 6, 2020

Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study

Neuro-degenerative Diseases
Bo NingJun Hua
November 13, 2020
Open Access

LRRK2 mediates tubulation and vesicle sorting from lysosomes

Science Advances
L. Bonet-PonceMark R Cookson
December 29, 2020
Open Access

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

The Biochemical Journal
Raja S NirujogiDario R Alessi

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