Parkinson's Disease: LRRK2

Parkinson’s disease (PD) is a neurodegenerative disorder that affects movement. This feed focuses on leucine-rich repeat kinase 2 (LRRK2) which is the most prominent genetic contributor to PD.

July 8, 2020
Open Access

Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity

Proceedings of the National Academy of Sciences of the United States of America
An Phu Tran NguyenDarren J Moore
July 28, 2020

High IQ in Early Adulthood Is Associated with Parkinson's Disease

Journal of Parkinson's Disease
Camilla FardellMaria Åberg
July 18, 2020

Evaluating the Role of SNCA, LRRK2, and GBA in Chinese Patients With Early-Onset Parkinson's Disease

Movement Disorders : Official Journal of the Movement Disorder Society
Yongping ChenHuifang Shang
July 18, 2020
Open Access

Remote Administration of the MDS-UPDRS in the Time of COVID-19 and Beyond

Journal of Parkinson's Disease
Ruth B SchneiderE Ray Dorsey
July 29, 2020
Open Access

Aspirin and ibuprofen could lower risk of LRRK2 Parkinson disease

Nature Reviews. Neurology
Ian Fyfe
July 28, 2020
Review

Animal Models of Parkinson's Disease: Are They Useful or Not?

Journal of Parkinson's Disease
Roger A Barker, Anders Bjorklund
July 12, 2020

BDNF Overexpression Increases Striatal D3 Receptor Level at Striatal Neurons and Exacerbates D1-Receptor Agonist-Induced Dyskinesia

Journal of Parkinson's Disease
Simona ScheggiManolo Carta
July 28, 2020
Open Access

Association Between Glucocerebrosidase Mutations and Parkinson's Disease in Ireland

Frontiers in Neurology
Diana Angelika OlszewskaTim Lynch
August 4, 2020
Review

Parkinson's Disease Drug Therapies in the Clinical Trial Pipeline: 2020

Journal of Parkinson's Disease
Kevin McFarthingSimon R W Stott
August 9, 2020
Review
Open Access

Progress in LRRK2 -Associated Parkinson's Disease Animal Models

Frontiers in Neuroscience
Steven P SeegobinZhenyu Yue
August 5, 2020
Review

Therapy of Parkinson's Disease Subtypes

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Connie MarrasTiago A Mestre
July 28, 2020

Modeling α-Synucleinopathy in Organotypic Brain Slice Culture with Preformed α-Synuclein Amyloid Fibrils

Journal of Parkinson's Disease
Amandine RouxJiyan Ma
July 17, 2020

Autophagy and Parkinson's Disease

Advances in Experimental Medicine and Biology
Jiahong LuZhenyu Yue
July 12, 2020
Review
Open Access

What People with Parkinson's Disease Want

Journal of Parkinson's Disease
John Andrejack, Soania Mathur
July 14, 2020
Preprint
Open Access

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

BioRxiv : the Preprint Server for Biology
S. H. SchmidtSusan S. Taylor
July 10, 2020
Open Access

LRRK2 activation controls the repair of damaged endomembranes in macrophages

The EMBO Journal
Susanne HerbstMaximiliano G Gutierrez
August 4, 2020

Oleh Hornykiewicz (1926-2020)

Journal of Parkinson's Disease
Andrew Lees, Werner Poewe

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