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Parkinson's Disease (Preprints)

Parkinson's Disease (Preprints)   diagram by Studio BKK, Shutterstock
Studio BKK, Shutterstock

Parkinson’s disease is a progressive neurodegenerative disorder that affects movement. This feed focuses on genetic screening approaches and genetic predispositions in Parkinson’s disease.

Top 20 most recent papers
bioRxiv

Integrated Sequencing & Array Comparative Genomic Hybridization in Familial Parkinson's Disease

bioRxivNovember 11, 2019
Laurie A. RobakJoshua M Shulman
24
3
bioRxiv

Single-cell epigenomic identification of inherited risk loci in Alzheimer's and Parkinson's disease

bioRxivJanuary 6, 2020
M. Ryan CorcesThomas J Montine
119
bioRxiv

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

bioRxivDecember 8, 2019
David R. BoyerDavid S. Eisenberg
14
bioRxiv

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease and progressive supranuclear palsy converge on altered glial regulation

bioRxivNovember 30, 2019
Kathryn R BowlesAlison M Goate
13
bioRxiv

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synuclein

bioRxivDecember 23, 2019
Eleanna KaraAdriano Aguzzi
38
bioRxiv

Dopamine modulates the size of striatal projection neuron ensembles

bioRxivDecember 5, 2019
Marta MalteseNicolas X Tritsch
107
bioRxiv

α-synuclein aggregates induce c-Abl activation and neurodegeneration by a redox stress mechanism

bioRxivNovember 13, 2019
Soumitra GhoshRaymond A Swanson
13
bioRxiv

Mimicry of dopamine 1 receptor signaling with Cell-Penetrating Peptides

bioRxivJanuary 7, 2020
Nicola LorenzonÜlo Langel
4
bioRxiv

Mining the Selective Remodeling of DNA Methylation in Promoter Regions to Identify Robust Gene-Level Associations with Phenotype

bioRxivJanuary 6, 2020
Quan YuanJianghui Xiong
12
bioRxiv

ERP sources in middle cingulate and precuneus differentiate Parkinson's patients from healthy controls and lingual gyri sources reflect human recombinant EPO effects in a Flanker task

bioRxivDecember 5, 2019
Maria L Bringas VegaPedro A. Valdes-Sosa
3
bioRxiv

A Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

bioRxivNovember 1, 2019
Paul P GeurinkHuib Ovaa
1
bioRxiv

Selective K-ATP channel-dependent loss of pacemaking in vulnerable nigrostriatal dopamine neurons by α-synuclein aggregates

bioRxivNovember 15, 2019
Poonam ThakurJochen Roeper
18
1
bioRxiv

The in situ structure of Parkinson's disease-linked LRRK2

bioRxivNovember 10, 2019
Reika WatanabeElizabeth Villa
164
21
bioRxiv

Dopaminergic Neurodegeneration Induced by Parkinson’s Disease-Linked G2019S LRRK2 is Dependent on Kinase and GTPase Activity

bioRxivDecember 18, 2019
An Phu Tran NguyenDarren J. Moore
6
bioRxiv

Disease associated protein-protein interaction network reconstruction based on comprehensive influence analysis

bioRxivDecember 18, 2019
Fei ZhuBairong Shen
7
bioRxiv

Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapse

bioRxivNovember 5, 2019
Dorien A. RoosenMark R Cookson
32
bioRxiv

CHCHD10 OR CHCHD2 ARE NOT REQUIRED FOR HUMAN MOTOR NEURON DIFFERENTIATION IN VITRO BUT MODIFY SYNAPTIC TRANSCRIPTOMES

bioRxivNovember 1, 2019
Sandra HarjuhaahtoHenna Tyynismaa
15
1
bioRxiv

A toolbox for automated video analysis of rodents engaged in string-pulling: Phenotyping motor behavior of mice for sensory, whole-body and bimanual skilled hand function

bioRxivDecember 22, 2019
Samsoon InayatMajid H. Mohajerani
62
bioRxiv

Transgenic mice expressing human alpha-synuclein in noradrenergic neurons develop locus coeruleus pathology and non-motor features of Parkinson's disease

bioRxivNovember 28, 2019
Laura M ButkovichMalu Gamez Tansey
22
bioRxiv

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at Chr16q11.2 and on the MAPT H1 allele.

bioRxivJanuary 7, 2020
Marc SoutarHelene Plun-Favreau
26

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