PARP Inhibitors

PARP inhibitors are a novel type of therapeutic agent being investigated for the treatment of some cancer types, particularly targeting tumors that are deficient in the homologous recombination DNA repair pathway. They have shown promise in BRCA mutations in breast cancer. Discover the latest research on PARP inhibitors here.

October 16, 2020
Open Access

A Flexible, Pooled CRISPR Library for Drug Development Screens

The CRISPR Journal
Maximilian BlanckBenedict C S Cross
October 26, 2020

Omentin: A novel therapeutic approach for the treatment of endothelial dysfunction in type 2 diabetes

Free Radical Biology & Medicine
Adriana LeandroCristina M Sena
October 24, 2020

Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue

Free Radical Biology & Medicine
Takujiro HommaJunichi Fujii
October 23, 2020
Open Access

Antioxidant and Cell Proliferation Properties of the Vietnamese Traditional Medicinal Plant Peltophorum pterocarpum

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Seon-Rye KimManh Hung Tran
October 23, 2020

Combinatorial Approaches to Enhance DNA Damage Following Enzyme-mediated Depletion of L-Cyst(e)ine for Treatment of Pancreatic Cancer

Molecular Therapy : the Journal of the American Society of Gene Therapy
Achinto SahaJohn DiGiovanni
October 16, 2020
Review

The DNA damaging revolution

Critical Reviews in Oncology/hematology
Bulent CetinOzge Gumusay
October 24, 2020

ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma

Cell Death & Disease
Zhuoyu GuYixin Li
October 23, 2020
Review

Dynamic action of DNA repair proteins as revealed by single molecule techniques: Seeing is believing

DNA Repair
Muwen KongBennett Van Houten
October 25, 2020
Review

An assessment of poly (ADP-ribose) polymerase-1 role in normal and cancer cells

BioFactors
Manoj KumarRana P Singh
October 21, 2020
Preprint
Open Access

HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation

BioRxiv : the Preprint Server for Biology
S. KumamotoMakoto Nakanishi
October 26, 2020

Plasma GSH levels and Alzheimer's Disease. A prospective approach.: Results from the HELIAD study

Free Radical Biology & Medicine
S CharisisN Scarmeas
October 24, 2020
Review

Anticholinergic Burden and Fractures: A Systematic Review with Methodological Appraisal

Drugs & Aging
Jonas ReinoldFederica Edith Pisa
October 26, 2020

MicroRNA-206 Inhibits Influenza A Virus Replication by Targeting Tankyrase 2

Cellular Microbiology
Gayan BamunuarachchiLin Liu
October 24, 2020

An evaluation of olaparib for the treatment of pancreatic cancer

Expert Opinion on Pharmacotherapy
Ulka N Vaishampayan

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