PARP Inhibitors

PARP inhibitors are a novel type of therapeutic agent being investigated for the treatment of some cancer types, particularly targeting tumors that are deficient in the homologous recombination DNA repair pathway. They have shown promise in BRCA mutations in breast cancer. Discover the latest research on PARP inhibitors here.

July 1, 2020
Open Access

The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation

Human Reproduction
Amy L WinshipKarla J Hutt
July 9, 2020
Open Access

Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570

International Journal of Molecular Sciences
Paola PellegriniPádraig D Arcy
July 3, 2020
Open Access

Efficacy and Prognostic Factors for PARP Inhibitors in Patients With Ovarian Cancer

Frontiers in Oncology
Xuan-Zhang HuangXin Zhou
July 1, 2020

Evolution of pathogenetic therapy of pulmonary arterial hypertension

Terapevticheskiĭ arkhiv
I E ChazovaN M Danilov
July 4, 2020
Open Access

Targeting Cellular Senescence in Cancer and Aging: Roles of p53 and its Isoforms

Carcinogenesis
Jessica BeckCurtis Harris
July 6, 2020

Poly adenosine diphosphate-ribosylation and neurodegenerative diseases

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
Yi Wang, Yunbi Lu
July 1, 2020
Review

Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections

Free Radical Biology & Medicine
Helmut Sies, Michael J Parnham
June 28, 2020

Characterization of the invitro cytotoxic effects of brachydins isolated from Fridericia platyphylla in a prostate cancer cell line

Journal of Toxicology and Environmental Health. Part a
Higor Lopes NunesIlce Mara de Syllos Cólus
July 9, 2020
Comment / Editorial

DNA Repair and Prostate Cancer: A Field Ripe for Harvest

European Urology
Alan H BryceJohann de Bono
July 1, 2020
Preprint
Open Access

Role of PARylation and PTEN Mutation on PARP and PARG Inhibitor Efficacy on Glioblastoma

BioRxiv : the Preprint Server for Biology
H. HermanowskiDelphine Quenet
July 1, 2020
Review

Systemic Therapy of Extensive Stage Small Cell Lung Cancer in the Era of Immunotherapy

Current Treatment Options in Oncology
Meera Ragavan, Millie Das
July 4, 2020

Tropisetron ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats

European Journal of Pharmacology
Mohammad Reza ZirakSoghra Mehri
July 9, 2020
Open Access

Fluorescence-guided resection of tumors in mouse models of oral cancer

Scientific Reports
Paula Demétrio de Souza FrançaThomas Reiner
July 1, 2020
Review
Open Access

Implications of NAD+ boosters in translational medicine

European Journal of Clinical Investigation
Baeki E KangDongryeol Ryu

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