PARP Inhibitors

PARP inhibitors are a novel type of therapeutic agent being investigated for the treatment of some cancer types, particularly targeting tumors that are deficient in the homologous recombination DNA repair pathway. They have shown promise in BRCA mutations in breast cancer. Discover the latest research on PARP inhibitors here.

October 25, 2021

High-fat diet aggravates colitis-associated carcinogenesis by evading ferroptosis in the ER stress-mediated pathway.

Free Radical Biology & Medicine
Xiaoli ZhangHongying Wang
October 26, 2021
Review
Open Access

Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair.

Frontiers in Cell and Developmental Biology
Catherine J PearsNicholas D Lakin
October 26, 2021
Review
Open Access

Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence.

BioMed Research International
Afsane BahramiAmirhossein Sahebkar
October 26, 2021

Reported evidence of vitamin E protection against cataract and glaucoma.

Free Radical Biology & Medicine
Masaki Tanito
October 22, 2021

Low plasma ergothioneine levels are associated with neurodegeneration and cerebrovascular disease in dementia.

Free Radical Biology & Medicine
Liu-Yun WuMitchell K P Lai
October 22, 2021

Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer.

Free Radical Biology & Medicine
Marina DelgoboAlfeu Zanotto-Filho
October 23, 2021
Open Access

Cellular Senescence limits Translational Readthrough.

Biology Open
Neylen Del ToroGerardo Ferbeyre
October 23, 2021
Comment / Editorial

PARP inhibitor sensitivity in BRCA-related metastatic breast cancer: an OlympiAD later.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
J Fuentes-Antrás, D W Cescon
October 23, 2021

The two-Cys-type TetR repressor GbaA confers resistance under disulfide and electrophile stress in Staphylococcus aureus.

Free Radical Biology & Medicine
Vu Van LoiHaike Antelmann
October 23, 2021

The nitroxide/antioxidant 3-carbamoyl proxyl attenuates disease severity in murine models of severe asthma.

Free Radical Biology & Medicine
Miri AssayagNeville Berkman
October 24, 2021
Review
Open Access

Recent Advances in Pancreatic Cancer: Novel Prognostic Biomarkers and Targeted Therapy-A Review of the Literature.

Biomolecules
Konstantin SchlickRichard Greil
October 24, 2021
Open Access

Precision Oncology of High-Grade Ovarian Cancer Defined through Targeted Sequencing.

Cancers
Sandra WessmanJoseph W Carlson
October 24, 2021

Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells.

Pharmaceuticals
Sergey A DyshlovoyGunhild von Amsberg

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