Peripheral Causes of Neurogeneration

Neurodegenerative diseases may be caused in part by influences from peripheral body systems as well as inflammation mediated by brain cells other than neurons. Understanding the roles of these influences is necessary to design treatments for neurodegenerative disease. Additionally, genetic tools allowing for delivery of transgenes past the blood-brain barrier are important for treatments of any CNS diseases. Discover the latest research on neurodegenerative disorders, their peripheral causes, and viral vectors for CNS delivery here.

August 3, 2020

Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex

Neurobiology of Disease
Tiziana PetrozzielloGhazaleh Sadri-Vakili
July 23, 2020

Peripheral inflammation exacerbates α-synuclein toxicity and neuropathology in Parkinson's models

Neuropathology and Applied Neurobiology
Pietro La VitolaGianluigi Forloni
July 17, 2020
Open Access

MicroRNA-223 Regulates Retinal Function and Inflammation in the Healthy and Degenerating Retina

Frontiers in Cell and Developmental Biology
Nilisha FernandoRiccardo Natoli
July 18, 2020
Open Access

Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications

Marta PajaresAntonio Cuadrado
July 30, 2020

Aging and sex: Impact on microglia phagocytosis

Aging Cell
Natalia Yanguas-CasásLuis Miguel Garcia-Segura
July 23, 2020
Open Access

COVID-19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases

Journal of Cellular Physiology
Iyer MahalaxmiVellingiri Balachandar
July 28, 2020
Open Access

Systemic inflammation causes microglial dysfunction with a mixed AD-like pathology.

BioRxiv : the Preprint Server for Biology
P. BathiniLavinia Alberi
July 28, 2020
Open Access

Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core

International Journal of Molecular Sciences
Elena VacchiGiorgia Melli
July 22, 2020

Synthesis and Characterization of 9-(4-[18 F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Takeshi FuchigamiSanjiv Sam Gambhir
July 16, 2020

Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

Cell Reports
Ying-Wooi WanBenjamin A Logsdon
July 27, 2020
Open Access

Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

Molecular Neurodegeneration
Nicholas F FitzRadosveta Koldamova
July 28, 2020
Case Report
Open Access

Spinal Muscular Atrophy in Blonde D'Aquitaine Calves Is Not Associated With FVT1 Gene Mutation

Frontiers in Veterinary Science
Giulia CagnottiClaudio Bellino
July 29, 2020
Open Access

CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation

Journal of Neuroinflammation
Elien GrajchenJeroen F J Bogie
July 28, 2020
Open Access

Adipose-Derived Stem Cells Reduce Lipopolysaccharide-Induced Myelin Degradation and Neuroinflammatory Responses of Glial Cells in Mice

Journal of Personalized Medicine
Kateryna YatsenkoOleg Tsupykov

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