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Pharmacogenetics & Pharmacogenomics

Pharmacogenetics & Pharmacogenomics diagram by Xie et al, PLOS Computational Biology
Xie et al, PLOS Computational Biology

Pharmacogenetics and pharmacogenomics (pgx) are rapidly growing fields that aim to elucidate the genetic basis for the interindividual differences in drug response. Here is the latest research on pharmacogenetics and pharmacogenomics.

Top 20 most recent papers
Scientific Reports

Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients

Scientific ReportsJanuary 19, 2020
Francesca ColomboAugusto Tommaso Caraceni
3
Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research

Cost-Effectiveness of RAS Genetic Testing Strategies in Patients With Metastatic Colorectal Cancer: A Systematic Review

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes ResearchJanuary 19, 2020
Brigid UnimPaolo Villari
3
10
Nature Communications

Chromosome arm aneuploidies shape tumour evolution and drug response

Nature CommunicationsJanuary 25, 2020
Ankit ShuklaPascal H G Duijf
19
Clinical and Translational Science

Impact of SLCO1B1 genetic variation on rosuvastatin systemic exposure in pediatric hypercholesterolemia

Clinical and Translational ScienceJanuary 26, 2020
Jonathan B WagnerJ Steven Leeder
Clinical Pharmacology and Therapeutics

Scientific and Regulatory Considerations for an Ontogeny Knowledge Base for Pediatric Clinical Pharmacology

Clinical Pharmacology and TherapeuticsJanuary 27, 2020
Gilbert J BurckartIssam Zineh
Pharmacogenomics

Pharmacogenetics and pharmacokinetics modeling of unexpected and extremely severe toxicities after sorafenib intake

PharmacogenomicsJanuary 23, 2020
Hai le BaSébastien Salas
1
Clinical Pharmacology and Therapeutics

MID3: Mission Impossible or Model-Informed Drug Discovery and Development? Point-Counterpoint Discussions on Key Challenges

Clinical Pharmacology and TherapeuticsJanuary 20, 2020
Sriram KrishnaswamiSandra A G Visser
3
Clinical Pharmacology and Therapeutics

The effect of orally administered dronabinol on optic nerve head blood flow in healthy subjects- a randomized clinical trial

Clinical Pharmacology and TherapeuticsJanuary 25, 2020
Nikolaus HommerDoreen Schmidl
bioRxiv

AITL: Adversarial Inductive Transfer Learning with input and output space adaptation for pharmacogenomics

bioRxivJanuary 25, 2020
Hossein Sharifi NoghabiMartin Ester
Basic & Clinical Pharmacology & Toxicology

Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes

Basic & Clinical Pharmacology & ToxicologyJanuary 25, 2020
Yvonne Elisabeth LaoKnut Erik Hovda
Frontiers in Pharmacology

Nephrotoxicity in a Patient With Inadequate Pain Control: Potential Role of Pharmacogenetic Testing for Cytochrome P450 2D6 and Apolipoprotein L1

Frontiers in PharmacologyJanuary 24, 2020
Emma M TillmanMichael T Eadon
Addiction

Systematic Review and Meta-Analysis of the Moderating Effect of rs1799971 in OPRM1, the Mu-opioid Receptor Gene, on Response to Naltrexone Treatment of Alcohol Use Disorder

AddictionJanuary 22, 2020
Emily E HartwellHenry R Kranzler
2
Drug Metabolism and Disposition : the Biological Fate of Chemicals

Alternative Splicing in the Nuclear Receptor Superfamily Redirects Human Metabolic Homeostasis

Drug Metabolism and Disposition : the Biological Fate of ChemicalsJanuary 26, 2020
Andrew J AnnaloraPatrick L Iversen
2
Clinical Pharmacology and Therapeutics

"In-House" Data on the Outside - A Mobile Health Approach

Clinical Pharmacology and TherapeuticsJanuary 20, 2020
Qinlei HuangS Aubrey Stoch
19
Clinical Pharmacology and Therapeutics

Data Integrity in Global Clinical Trials: Discussions from Joint US FDA and MHRA UK Good Clinical Practice Workshop

Clinical Pharmacology and TherapeuticsJanuary 21, 2020
Ni A KhinStephen Vinter
Clinical Pharmacology and Therapeutics

Pharmacokinetics and pharmacodynamics of intensive anti-tuberculosis treatment of tuberculous meningitis

Clinical Pharmacology and TherapeuticsJanuary 21, 2020
Junjie DingJoel Tarning
11
European Review for Medical and Pharmacological Sciences

Assessment of pharmacogenomic SLCO1B1 assay for prediction of neuromuscular pain in type 2 diabetes mellitus and cardiovascular patients: preliminary results

European Review for Medical and Pharmacological SciencesJanuary 21, 2020
A LicitoD De Lucia
Clinical Pharmacology and Therapeutics

Development of a System for Post-marketing Population Pharmacokinetic and Pharmacodynamic Studies using Real-World Data from Electronic Health Records

Clinical Pharmacology and TherapeuticsJanuary 21, 2020
Leena ChoiSara L Van Driest
2
Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research

Cost-Effectiveness of Multigene Pharmacogenetic Testing in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes ResearchJanuary 19, 2020
Olivia M DongTim Wiltshire
4
1
Clinical Pharmacology and Therapeutics

Open Models for Clinical Pharmacology

Clinical Pharmacology and TherapeuticsJanuary 27, 2020
Daniel C Kirouac

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