PI3K/AKT/mTOR Pathway

The PI3K/AKT/mTOR signal transduction pathway is crucial for cell cycle, thus directly regulates cell proliferation, longevity, and cancer. Here is the latest research on this intracellular signaling pathway.

February 28, 2021

Enrichment of IGF-1R and PPARγ signalling pathways in orbital inflammatory diseases: steps toward understanding pathogenesis.

The British Journal of Ophthalmology
Rohan VermaJames T Rosenbaum
February 27, 2021
Open Access

ATR activation is regulated by dimerization of ATR activating proteins.

The Journal of Biological Chemistry
Vaughn Thada, David Cortez
February 27, 2021
Open Access

NVP-BEZ235 or JAKi Treatment leads to decreased survival of examined GBM and BBC cells.

Cancer Treatment and Research Communications
Neftali VazquezMegan Keniry
February 26, 2021
Preprint
Open Access

PI3K Signaling Specifies Proximal-Distal Fate by Driving a Developmental Gene Regulatory Network in Sox9+ Lung Progenitors

BioRxiv : the Preprint Server for Biology
D. KhattarDaniel T Swarr
February 26, 2021
Open Access

Arctigenin triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in PC-3M cells.

Chemical & Pharmaceutical Bulletin
Bai-Ling SunJing-Yao Wang
February 26, 2021
Open Access

An Integrated Strategy for Effective-Component Discovery of Astragali Radix in the Treatment of Lung Cancer.

Frontiers in Pharmacology
Bing YangXiaobin Jia
February 26, 2021
Open Access

Uncovering the Anti-Lung-Cancer Mechanisms of the Herbal Drug FDY2004 by Network Pharmacology.

Evidence-based Complementary and Alternative Medicine : ECAM
Ho-Sung LeeDae-Yeon Lee
February 26, 2021
Open Access

Epigallocatechin Gallate Protects against MNNG-Induced Precancerous Lesions of Gastric Carcinoma in Rats via PI3K/Akt/mTOR Pathway.

Evidence-based Complementary and Alternative Medicine : ECAM
Feiye ZhuGuanqun Xie
February 26, 2021
Review
Open Access

Oxidative Imbalance as a Crucial Factor in Inflammatory Lung Diseases: Could Antioxidant Treatment Constitute a New Therapeutic Strategy?

Oxidative Medicine and Cellular Longevity
Tatiana VictoniVinicius F Carvalho
February 26, 2021

[Neuroprotective effects of linagliptin on ischemia/reperfusion in mice].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Bo Zhao, Hai-Ping Wei
February 25, 2021

Lophira alata Suppresses Phorbol Ester-Mediated Increase in Cell Growth via Inhibition of Protein Kinase C-α/Akt in Glioblastoma Cells.

Anti-cancer Agents in Medicinal Chemistry
Ifeoma EzenyiSamson Amos
February 25, 2021
Open Access

Role of gambogenic acid in regulating PI3K/Akt/NF-kβ signaling pathways in rat model of acute hepatotoxicity.

Bioscience, Biotechnology, and Biochemistry
Zhongyang DingBei Lu
February 25, 2021

P110α and P110δ catalytic subunits of PI3 kinase regulate lysophosphatidylcholine-induced TRPC6 externalization.

American Journal of Physiology. Cell Physiology
Pinaki ChaudhuriMichael A Rosenbaum

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