Pioneer factors are a class of transcription factors that possess the ability to bind to compact chromatin. This can lead to the recruitment of other proteins that regulate transcription. Discover the latest research on pioneer factors here.
This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.
Bivalent chromatin are segments of DNA, bound to histone proteins, that have both repressing and activating epigenetic regulators in the same region. Here is the latest research on bivalent chromatin and gene expression.
This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.
Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.
Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) is a genome-wide technique used to map histone marks and protein binding (i.e. transcription factors) on chromatin. This can reveal insight into the regulation and dynamics of gene expression. Discover the latest research on ChIP-seq here.
The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on chromatin regulation and circadian clocks here.
Chromatin regulators affect gene expression by influencing the access of proteins such as transcription factors to DNA. Here is the latest research on the role of chromatin regulating proteins in cellular differentiation.
Chromatin remodeling is essential for regulation of gene expression, DNA replication, as well as DNA repair. Here is the latest research on chromatin remodeling complexes and mechanisms underlying this process.
Cryogenic electron microscopy (Cryo-EM) uses a specific technique to allow for the visualization of macromolecules and their assemblies at a near-atomic resolution. Discover the latest research on Cryo-EM here.
DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.