Pioneer Factors (Keystone)

Pioneer factors are a class of transcription factors that possess the ability to bind to compact chromatin. This can lead to the recruitment of other proteins that regulate transcription. Discover the latest research on pioneer factors here.

January 12, 2020
Open Access

Spatiotemporal control of gene expression boundaries using a feedforward loop

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Prasad U BandodkarGregory T Reeves
June 17, 2020

Regulation of spatiotemporal limits of developmental gene expression via enhancer grammar

Proceedings of the National Academy of Sciences of the United States of America
Samuel H KellerBomyi Lim
March 18, 2020
Open Access

LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate

BioRxiv : the Preprint Server for Biology
Run JinDoris Wagner
February 10, 2020
Open Access

High throughput screening identifies SOX2 as a Super Pioneer Factor that inhibits DNA methylation maintenance at its binding sites

BioRxiv : the Preprint Server for Biology
Ludovica VanzanRabih Murr
August 5, 2020
Open Access

FoxA factors: the chromatin key and doorstop essential for liver development and function

Genes & Development
James A Heslop, Stephen A Duncan
January 9, 2020
Open Access

Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Jung S ByunKevin Gardner
May 21, 2020
Open Access

The FOXA1 transcriptional network coordinates key functions of primary human airway epithelial cells

American Journal of Physiology. Lung Cellular and Molecular Physiology
Alekh ParanjapyeAnn Harris
October 5, 2019
Open Access

The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos

Nature Communications
Jelena ErcegC-Ting Wu
January 11, 2020
Open Access

The spatial binding model of the pioneer factor Oct4 with its target genes during cell reprogramming

Computational and Structural Biotechnology Journal
Hanshuang LiYongchun Zuo
June 28, 2020

From mother to embryo: A molecular perspective on zygotic genome activation

Current Topics in Developmental Biology
Edlyn Wu, Nadine L Vastenhouw
May 10, 2020
Open Access

Pioneer factor GAF cooperates with PBAP and NURF to regulate transcription

BioRxiv : the Preprint Server for Biology
J. JuddJohn T Lis
December 19, 2019
Open Access

Insights into Gene Regulatory Networks in Chondrocytes

International Journal of Molecular Sciences
Hironori Hojo, Shinsuke Ohba
June 21, 2020
Open Access

Collapse of the hepatic gene regulatory network in the absence of FoxA factors

Genes & Development
Yitzhak ReizelKlaus H Kaestner
July 24, 2020
Open Access

Odd-paired is a pioneer-like factor that coordinates with Zelda to control gene expression in embryos

Theodora KoromilaAngelike Stathopoulos
November 16, 2019

Exogenous ERα Expression in the Mammary Epithelium Decreases Over Time and Does Not Contribute to p53-Deficient Mammary Tumor Formation in Mice

Journal of Mammary Gland Biology and Neoplasia
Lisette M CornelissenJos Jonkers
April 17, 2020

Pioneer factors and their in vitro identification methods

Molecular Genetics and Genomics : MGG
Xinyang Yu, Michael J Buck
May 25, 2020
Open Access

TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development

Cellular and Molecular Life Sciences : CMLS
Mei YiBo Xiang
May 1, 2020

Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function

Svetlana O DodonovaPatrick Cramer

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