Polypharmacologic Drug Screening

Polypharmacologic drug screening is the screening of pharmaceutical agents that act on multiple targets or disease pathways. Discover the latest research on polypharmacologic drug screening here,

September 15, 2021

Congenital Cytomegalovirus Targeted Screening Implementation and Outcomes: A Retrospective Chart Review.

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Evette A RonnerMichael Cohen
September 15, 2021
Open Access

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge.

PLoS Computational Biology
Zhaoping XiongRoss Cagan
September 14, 2021

PATHOME-Drug: a subpathway-based poly-pharmacology drug-repositioning method.

Bioinformatics
Seungyoon NamTaesung Park
September 10, 2021
Preprint
Open Access

Phomoarcherin B as a novel HIV-1 reverse transcriptase RNase H activity inhibitor: conclusions from comprehensive computational analysis

BioRxiv : the Preprint Server for Biology
Naeem Abdul GhafoorR. S. Silme
September 10, 2021
Review

Recent Advances in In Silico Target Fishing.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Salvatore GalatiTiziano Tuccinardi
September 7, 2021
Review

Phytochemistry and polypharmacology of cleome species: A comprehensive Ethnopharmacological review of the medicinal plants.

Journal of Ethnopharmacology
Jagdish ChandV G M Naidu
September 3, 2021

Dual Targeting Strategies On Histone Deacetylase 6 (HDAC6) And Heat Shock Protein 90 (Hsp90).

Current Medicinal Chemistry
Davide BonanniGiulio Rastelli
September 3, 2021
Preprint
Open Access

Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic

BioRxiv : the Preprint Server for Biology
Y. L. ChowGregory P. Way
September 2, 2021
Open Access

Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase - Design, synthesis and biological evaluation.

Computational and Structural Biotechnology Journal
Chandran RemyaR V Omkumar
September 1, 2021

Drug repositioning for anti-tuberculosis drugs: an in silico polypharmacology approach.

Molecular Diversity
Sita Sirisha MadugulaG Narahari Sastry
August 31, 2021

Design, synthesis and biological evaluation of dual HDAC and VEGFR inhibitors as multitargeted anticancer agents.

Investigational New Drugs
Xia XueXiaogang Zhao
August 30, 2021

A computational study on hydroxychloroquine binding to target proteins related to SARS-COV-2 infection.

Informatics in Medicine Unlocked
V B Navya, M V Hosur
August 25, 2021

A Sort-Seq Approach to the Development of Single Fluorescent Protein Biosensors.

ACS Chemical Biology
John N KobersteinMichael Cohen
August 20, 2021

Hearing Aid Use in Children With Unilateral Hearing Loss: A Randomized Crossover Clinical Trial.

The Laryngoscope
Liliya BenchetritMichael Cohen
August 18, 2021

Full paper systematic mapping of R-group space enables the generation of an R-group replacement system for medicinal chemistry.

European Journal of Medicinal Chemistry
Kosuke TakeuchiJürgen Bajorath
August 16, 2021

International Survey of Operative Practices for Otologists and Neurotologists During the COVID-19 Crisis.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Sarah E RidgeDaniel J Lee
August 15, 2021

Development of curcumin-based amyloid β aggregation inhibitors for Alzheimer's disease using the SAR matrix approach.

Bioorganic & Medicinal Chemistry
Rohmad Yudi UtomoHiroyuki Nakamura
August 14, 2021

Identification and characterization of two structurally related dipeptides that enhance catalytic efficiency of neurolysin.

The Journal of Pharmacology and Experimental Therapeutics
Srinidhi JayaramanVardan T Karamyan

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