Polypharmacologic Drug Screening

Polypharmacologic drug screening is the screening of pharmaceutical agents that act on multiple targets or disease pathways. Discover the latest research on polypharmacologic drug screening here,

August 1, 2020
Open Access

Antidepression and Prokinetic Effects of Paeoniflorin on Rats in the Forced Swimming Test via Polypharmacology

Evidence-based Complementary and Alternative Medicine : ECAM
Dao-Zhou MuXi Huang
September 5, 2020
Open Access

Identification of promising antiviral drug candidates against non-structural protein 15 (NSP15) from SARS-CoV-2: an in silico assisted drug-repurposing study

Journal of Biomolecular Structure & Dynamics
Rameez Jabeer KhanAmit Kumar Singh
September 12, 2020

Multi-targeted drug design strategies for the treatment of schizophrenia

Expert Opinion on Drug Discovery
Piotr StępnickiAgnieszka A Kaczor
September 13, 2020

Drugs, host proteins and viral proteins: how their promiscuities shape antiviral design

Biological Reviews of the Cambridge Philosophical Society
Munishwar Nath Gupta, Ipsita Roy
September 9, 2020
Open Access

Prediction of an MMP-1 inhibitor activity cliff using the SAR matrix approach and its experimental validation

Scientific Reports
Yasunobu AsawaHiroyuki Nakamura
August 14, 2020

Evaluation of novobiocin and telmisartan for anti-CHIKV activity

Praveen Kumar TripathiAshok Kumar Patel
August 28, 2020
Open Access

Prostate Epithelial Genes Define Docetaxel-Sensitive Prostate Cancer Molecular Subtype

BioRxiv : the Preprint Server for Biology
H. HanYoung Deuk Choi
September 10, 2020
Open Access

Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology

The Journal of Biological Chemistry
Marcus J G W LaddsSonia Laín
July 8, 2020
Open Access

Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

NPJ Systems Biology and Applications
Jing TangTero Aittokallio
June 11, 2020
Open Access

This elusive unknown quantity: reflections on the prescription of psychotropic drugs in early childhood

Ciência & saúde coletiva
Mariana Nogueira Rangel PandeTatiana Wargas de Faria Baptista
May 31, 2020
Open Access

X-ray Structure-Based Chemoinformatic Analysis Identifies Promiscuous Ligands Binding to Proteins from Different Classes with Varying Shapes

International Journal of Molecular Sciences
Christian Feldmann, Jürgen Bajorath
August 17, 2020
Open Access

In silico discovery and biological validation of ligands of FAD synthase, a promising new antimicrobial target

PLoS Computational Biology
Isaias LansPilar Cossio
July 9, 2020
Comment / Editorial

Evidence for the presence of core structure-dependent activity cliffs

Future Medicinal Chemistry
Huabin Hu, Jürgen Bajorath
September 15, 2020

Challenges with matrix metalloproteinase inhibition and future drug discovery avenues

Expert Opinion on Drug Discovery
Thomas Fischer, Rainer Riedl
August 18, 2020
Open Access

3,6-Disubstituted 1,2,4-Triazolo[3,4-b ]Thiadiazoles with Anticancer Activity Targeting Topoisomerase II Alpha

OncoTargets and Therapy
Sofia SagredouDimitrios T Trafalis
August 4, 2020

Identifying representative kinases for inhibitor evaluation via systematic analysis of compound-based target relationships

European Journal of Medicinal Chemistry
Oliver LaufkötterJürgen Bajorath
July 16, 2020
Comment / Editorial
Open Access

New Horizons in Drug Discovery - Understanding and Advancing Kinase Inhibitors

Journal of Medicinal Chemistry
Stefan LauferShaomeng Wang

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