Polypharmacologic Drug Screening

Polypharmacologic drug screening is the screening of pharmaceutical agents that act on multiple targets or disease pathways. Discover the latest research on polypharmacologic drug screening here,

May 27, 2020

An up-to-date overview of computational polypharmacology in modern drug discovery

Expert Opinion on Drug Discovery
Rajan ChaudhariShuxing Zhang
March 19, 2020
ReviewOpen Access

Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Giovanni StelitanoLaurent Roberto Chiarelli
March 18, 2020

Kendomycin Cytotoxicity against Bacterial, Fungal, and Mammalian Cells Is Due to Cation Chelation

Journal of Natural Products
Dale TranterDominic Hoepfner
March 10, 2020
Open Access

How polypharmacologic is each chemogenomics library?

Future Drug Discovery
Eric NiTimothy Cardozo
May 28, 2020
Open Access

Structure-based drug repositioning explains ibrutinib as VEGFR2 inhibitor

PloS One
Melissa F AdasmeMichael Schroeder
March 7, 2020
Open Access

Integrating computational lead optimization diagnostics with analog design and candidate selection

Future Science OA
Dimitar Yonchev, Jürgen Bajorath
February 22, 2020

A Natural Product Puts Malaria on a Low-Fat Diet

Cell Chemical Biology
Daniel LucyEdward W Tate
April 17, 2020

Bioisosteric discovery of NPA101.3, a second generation RET/VEGFR2 inhibitor optimized for single-agent polypharmacology

Journal of Medicinal Chemistry
Marialuisa MocciaFrancesca Carlomagno
May 10, 2020
Open Access

Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Annalisa MarucaStefano Alcaro
April 30, 2020

Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors

ChemMedChem
Aubry Kern MillerNikolas Gunkel
May 31, 2020

X-ray Structure-Based Chemoinformatic Analysis Identifies Promiscuous Ligands Binding to Proteins from Different Classes with Varying Shapes

International Journal of Molecular Sciences
Christian Feldmann, Jürgen Bajorath
May 2, 2020
ReviewOpen Access

QSAR without borders

Chemical Society Reviews
Eugene N MuratovAlexander Tropsha
May 22, 2020
Review

Drug rechanneling: a novel paradigm for cancer treatment

Seminars in Cancer Biology
Itishree KaushikSanjay K Srivastava
May 26, 2020
Review

A Perspective on Multi-target Drugs for Alzheimer's Disease

Trends in Pharmacological Sciences
Ondrej BenekOndrej Soukup
January 23, 2020

The impact of chemoinformatics on drug discovery in the pharmaceutical industry

Expert Opinion on Drug Discovery
Karina Martinez-MayorgaGerald Maggiora
May 2, 2020
Open Access

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

The Journal of Biological Chemistry
Martin ZoltnerMark C Field
February 8, 2020
Open Access

Discovery of Novel Inhibitors Targeting Multi-UDP-hexose Pyrophosphorylases as Anticancer Agents

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yueqin YangKent Lai

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