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Position Effect Variegation

Position Effect Variegation diagram by Heiti Paves, Shutterstock
Heiti Paves, Shutterstock

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Top 20 most recent papers
Genome Biology

Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome

Genome BiologyMarch 12, 2017
Warren A CheungElin Grundberg
8
90
bioRxiv

On the relation of phase separation and Hi-C maps to epigenetics

bioRxivOctober 24, 2019
Prim B. Singh, Andrew G. Newman
11
8
Clinical Genetics

Copy number variants analysis in a cohort of isolated and syndromic developmental delay/intellectual disability reveals novel genomic disorders, position effects and candidate disease genes

Clinical GeneticsMarch 16, 2017
E Di GregorioG B Ferrero
6
1
1
42
Cell

An Abundant Class of Non-coding DNA Can Prevent Stochastic Gene Silencing in the C. elegans Germline

CellJuly 5, 2016
Christian Frøkjær-JensenAndrew Z Fire
28
1
1
187
1
PLoS Genetics

Ribosomal DNA copy number loss and sequence variation in cancer

PLoS GeneticsJune 24, 2017
Baoshan XuJennifer L Gerton
12
9
3
85
1
American Journal of Human Genetics

Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements

American Journal of Human GeneticsJuly 25, 2017
Cinthya J Zepeda-MendozaCynthia C Morton
24
4
58
bioRxiv

Drosophila small ovary encodes a zinc-finger repressor required for ovarian differentiation

bioRxivJune 24, 2018
Leif BennerDorothy A Lerit
22
3
bioRxiv

The Impact of Genetic Background and Cell Lineage on the Level and Pattern of Position Effect Variegation

bioRxivAugust 20, 2019
Sidney H Wang, Sarah C R Elgin
5
1
bioRxiv

Position Effect Variegation In Natural Populations Not Explained By Common Variation In Known Modifiers

bioRxivApril 24, 2017
Keegan J P Kelsey, Andrew G Clark
10
1
bioRxiv

Drosophila small ovary gene ensures germline stem cell maintenance and differentiation by silencing transposons and organising heterochromatin

bioRxivAugust 2, 2018
Ferenc JankovicsMiklós Erdélyi
7
Proceedings of the National Academy of Sciences of the United States of America

Drosophila larvae synthesize the putative oncometabolite L-2-hydroxyglutarate during normal developmental growth

Proceedings of the National Academy of Sciences of the United States of AmericaJanuary 25, 2017
Hongde LiJason M Tennessen
6
12
1
31
1
bioRxiv

An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain

bioRxivMay 15, 2019
Emmanuel DebrandPeter Fraser
3
Proceedings of the National Academy of Sciences of the United States of America

Generalized nucleation and looping model for epigenetic memory of histone modifications

Proceedings of the National Academy of Sciences of the United States of AmericaJuly 7, 2016
Fabian Erdel, Eric C Greene
27
118
Current Protocols in Human Genetics

Computational Prediction of Position Effects of Human Chromosome Rearrangements

Current Protocols in Human GeneticsJuly 25, 2018
Cinthya J Zepeda-MendozaCynthia C Morton
1
bioRxiv

A Game of Thrones at Human Centromeres II. A new molecular/evolutionary model

bioRxivAugust 10, 2019
William Richard Rice
17
Hematology/oncology Clinics of North America

Nonintegrating Gene Therapy Vectors

Hematology/oncology Clinics of North AmericaSeptember 13, 2017
Takis AthanasopoulosRafael J Yáñez-Muñoz
2
65
PloS One

Generation of a Stable Transgenic Swine Model Expressing a Porcine Histone 2B-eGFP Fusion Protein for Cell Tracking and Chromosome Dynamics Studies

PloS OneJanuary 13, 2017
Renan B SperJorge A Piedrahita
Current Genetics

Are all repeats created equal? Understanding DNA repeats at an individual level

Current GeneticsJune 5, 2016
Jinpu Yang, Fei Li
10
34
bioRxiv

A Novel Chromatin-Opening Element for Stable Long-term Transgene Expression

bioRxivMay 3, 2019
Shireen S. Rudina, Christina D. Smolke
5
6
Genome Génome / Conseil National De Recherches Canada

Mutations in ash1 and trx enhance P-element-dependent silencing in Drosophila melanogaster

Genome Génome / Conseil National De Recherches CanadaJuly 5, 2016
Allen McCracken, John Locke
3
1
1

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