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Prion Disease

Prion Disease diagram by Dr. Al Jenny - Public Health Image Library, APHIS (Public Domain)
Dr. Al Jenny - Public Health Image Library, APHIS (Public Domain)

Prion diseases or transmissible spongiform encephalopathies are rare progressive neurogenerative diseases caused by misfolded prion proteins. Here is the latest research in this domain.

Top 20 most recent papers
Angewandte Chemie

Rare 3-O-sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake

Angewandte ChemieNovember 6, 2019
Jing ZhaoChun-yu Wang
2
1
bioRxiv

Loss of region-specific glial homeostatic signature in prion diseases

bioRxivOctober 30, 2019
Natallia MakaravaIlia V Baskakov
2
bioRxiv

Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers

bioRxivOctober 29, 2019
Ladan Amin, David Alan Harris
6
Scientific Reports

Scrapie susceptibility-associated indel polymorphism of shadow of prion protein gene (SPRN) in Korean native black goats

Scientific ReportsOctober 24, 2019
Yong-Chan KimByung-Hoon Jeong
Scientific Reports

Potential scrapie-associated polymorphisms of the prion protein gene (PRNP) in Korean native black goats

Scientific ReportsOctober 25, 2019
Seon-Kwan KimByung-Hoon Jeong
1
Scientific Reports

Amyloid fibrils prepared using an acetylated and methyl amidated peptide model of the α-Synuclein NAC 71-82 amino acid stretch contain an additional cross-β structure also found in prion proteins

Scientific ReportsNovember 4, 2019
Thomas NäsströmBjorn C G Karlsson
Acta Neuropathologica

Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions

Acta NeuropathologicaOctober 31, 2019
Patricia Aguilar-CalvoChristina J Sigurdson
3
2
1
Alzheimer's & Dementia : the Journal of the Alzheimer's Association

Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias

Alzheimer's & Dementia : the Journal of the Alzheimer's AssociationOctober 24, 2019
Anna AntonellRaquel Sanchez-Valle
24
1
1
bioRxiv

Characterization of the prion protein binding properties of antisense oligonucleotides

bioRxivNovember 7, 2019
Andrew G ReidenbachSonia M Vallabh
21
Scientific Reports

Transgenic mouse models expressing human and macaque prion protein exhibit similar prion susceptibility on a strain-dependent manner

Scientific ReportsOctober 30, 2019
Juan Carlos EspinosaJuan Maria Torres
Cell Chemical Biology

Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System

Cell Chemical BiologyOctober 21, 2019
Zhiqiang DuLiming Li
3
1
Brain and nerve = Shinkei kenkyū no shinpo

The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases

Brain and nerve = Shinkei kenkyū no shinpoNovember 1, 2019
Takashi Nonaka
BMJ Open

Study protocol for enhanced CJD surveillance in the 65+ years population group in Scotland: an observational neuropathological screening study of banked brain tissue donations for evidence of prion disease

BMJ OpenOctober 28, 2019
Alexander H PedenAnna M Molesworth
Current Pharmaceutical Design

Neurotoxic and Neuroprotective Role of Exosomes in Parkinson's Disease

Current Pharmaceutical DesignNovember 12, 2019
Biancamaria LongoniRoberto Maggio
Biomacromolecules

α-Synuclein penetrates mucin hydrogels despite its mucoadhesive properties

BiomacromoleculesNovember 13, 2019
Matthias MarczynskiOliver Lieleg
The Journal of General Virology

Eliminating transmissibility of bovine spongiform encephalopathy by dry-heat treatment

The Journal of General VirologyNovember 13, 2019
Yuichi MatsuuraShirou Mohri
Viruses

Transmissibility versus Pathogenicity of Self-Propagating Protein Aggregates

VirusesNovember 9, 2019
Byron W Caughey, Allison Kraus
Brain and nerve = Shinkei kenkyū no shinpo

Neuropathology of Amyotrophic Lateral Sclerosis

Brain and nerve = Shinkei kenkyū no shinpoNovember 1, 2019
Mari W Yoshida
Neural Regeneration Research

Cerebrospinal fluid neurogranin as a new player in prion disease diagnosis and prognosis

Neural Regeneration ResearchNovember 14, 2019
Anna Villar-PiquéFranc Llorens
Scientific Reports

Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau

Scientific ReportsNovember 12, 2019
Anett HudákTamás Letoha

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