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Prion Diseases: strain diversity and neurotoxicity

Prion Diseases: strain diversity and neurotoxicity diagram by ibreakstock, Shutterstock
ibreakstock, Shutterstock

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Distinct prion strains are associated with different prion protein conformations and glycosylation patterns and associate with disease progression and severity. Here is the latest research on strain diversity and neurotoxicity in prion diseases.

Top 20 most recent papers
bioRxiv

Loss of region-specific glial homeostatic signature in prion diseases

bioRxivOctober 30, 2019
Natallia MakaravaIlia V Baskakov
2
3
bioRxiv

Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers

bioRxivOctober 29, 2019
Ladan Amin, David A Harris
6
bioRxiv

Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

bioRxivDecember 6, 2019
Kirby M DonnellyMargaret M Panning Pearce
23
bioRxiv

Intercellular transmission of a bacterial cytotoxic prion-like protein in mammalian cells

bioRxivOctober 30, 2019
Aida Revilla-GarcíaRafael Giraldo
18
Scientific Reports

Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau

Scientific ReportsNovember 14, 2019
Anett HudákTamás Letoha
10
1
5
Acta Neuropathologica

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

Acta NeuropathologicaDecember 20, 2019
Grant T CorbettDominic M Walsh
34
1
bioRxiv

Genetic ablation of SOD1G37R selectively from corticofugal projection neurons protects corticospinal neurons from degeneration without affecting ALS onset and progression

bioRxivJanuary 10, 2020
Jelena Scekic-ZahirovicCaroline Rouaux
3
Cell Chemical Biology

Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System

Cell Chemical BiologyNovember 1, 2019
Zhiqiang DuLiming Li
3
1
7
NeuroImage. Clinical

Prion disease diagnosis using subject-specific imaging biomarkers within a multi-kernel Gaussian process

NeuroImage. ClinicalNovember 18, 2019
Liane S CanasMarc Modat
5
1
1
Annals of Indian Academy of Neurology

Familial Creutzfeldt-Jakob Disease in an Indian Kindred

Annals of Indian Academy of NeurologyNovember 19, 2019
Sarosh M KatrakJohn Collinge
1
Neuron

Axons Gonna Ride 'til They Can't No More

NeuronOctober 25, 2019
Steven Boeynaems, Aaron D Gitler
37
1
13
Seminars in Cell & Developmental Biology

Prions and Prion-like assemblies in neurodegeneration and immunity: The emergence of universal mechanisms across health and disease

Seminars in Cell & Developmental BiologyDecember 11, 2019
Ailis O'CarrollYann Gambin
3
1
Cellular and Molecular Life Sciences : CMLS

Mechanisms of secretion and spreading of pathological tau protein

Cellular and Molecular Life Sciences : CMLSNovember 1, 2019
Cecilia A BrunelloHenri J Huttunen
1
1
12
PLoS Biology

Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation

PLoS BiologyNovember 22, 2019
Ying-Qiu ZhengAlain Dagher
110
1
13
Mechanisms of Ageing and Development

Neuroglial patterns are shared by cerebella from prion and prion-like disorder affected patients

Mechanisms of Ageing and DevelopmentNovember 7, 2019
Moisés GarcésMarta Monzón
1
2
Brain and nerve = Shinkei kenkyū no shinpo

The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases

Brain and nerve = Shinkei kenkyū no shinpoNovember 14, 2019
Takashi Nonaka
1
1
ACS Chemical Neuroscience

Preferential Recruitment of Conformationally Distinct Amyloid-β Oligomers by the Intrinsically Disordered Region of the Human Prion Protein

ACS Chemical NeuroscienceDecember 7, 2019
Priyanka Madhu, Samrat Mukhopadhyay
19
1
Journal of Theoretical Biology

Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain and its connectome

Journal of Theoretical BiologyDecember 7, 2019
Sveva FornariAlain Goriely
7
1
Current Pharmaceutical Design

Role of dietary antioxidants in neurodegenerative diseases: Where are we standing?

Current Pharmaceutical DesignJanuary 10, 2020
Sena BakirMohammad Amjad Kamal
3
1
1
Future Science OA

Regenerative medicine: could Parkinson's be the first neurodegenerative disease to be cured?

Future Science OAOctober 15, 2019
Mariacruz L Díaz
12
1
14

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