Prion Diseases: strain diversity and neurotoxicity

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Distinct prion strains are associated with different prion protein conformations and glycosylation patterns and associate with disease progression and severity. Here is the latest research on strain diversity and neurotoxicity in prion diseases.

May 29, 2020

Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

ELife
Kirby M DonnellyMargaret M Panning Pearce
May 9, 2020
Open Access

RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

Molecular Brain
James A CarrollBruce Chesebro
April 5, 2020
Review
Open Access

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

International Journal of Molecular Sciences
Masaru TanakaLászló Vécsei
May 18, 2020

Soy flavonoids prevent cognitive deficits induced by intra-gastrointestinal administration of beta-amyloid

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Julia Y H LiuJohn A Rudd
June 14, 2020

Metabolomic study of disease progression in scrapie prion infected mice; validation of a novel method for brain metabolite extraction

Metabolomics : Official Journal of the Metabolomic Society
Ze-Lin FuBrian D Sykes
March 21, 2020
Open Access

Neurodegeneration-Associated Proteins in Human Olfactory Neurons Collected by Nasal Brushing

Frontiers in Neuroscience
Lorenzo BrozzettiGianluigi Zanusso
March 9, 2020
Preprint
Open Access

Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration

BioRxiv : the Preprint Server for Biology
Juliane ObstDiego Gomez-Nicola
March 25, 2020
Review
Open Access

The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases

International Journal of Molecular Sciences
Wioletta Rozpędek-KamińskaIreneusz Majsterek
January 21, 2020
Open Access

CSF SerpinA1 in Creutzfeldt-Jakob disease and frontotemporal lobar degeneration

Annals of Clinical and Translational Neurology
Samir Abu-RumeilehMarkus Otto
April 18, 2020
Open Access

Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease

Brain : a Journal of Neurology
Ilaria VanniRomolo Nonno
May 5, 2020

The Braak hypothesis in prion disease with a focus on Creutzfeldt-Jakob disease

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Yasushi Iwasaki
January 10, 2020

Role of dietary antioxidants in neurodegenerative diseases: Where are we standing?

Current Pharmaceutical Design
Sena BakirMohammad Amjad Kamal
January 9, 2020

3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases

The International Journal of Neuroscience
Maria Bandookwala, Pinaki Sengupta
February 29, 2020
Open Access

Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease

The Biochemical Journal
Alana M ThackrayRaymond Bujdoso
February 29, 2020
Review

Preclinical biomarkers of prion infection and neurodegeneration

Current Opinion in Neurobiology
Tze How Mok, Simon Mead
February 23, 2020

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease

Molecular Therapy : the Journal of the American Society of Gene Therapy
Antonio MonacoAlessandro Fraldi

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