Prion Diseases: strain diversity and neurotoxicity

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Distinct prion strains are associated with different prion protein conformations and glycosylation patterns and associate with disease progression and severity. Here is the latest research on strain diversity and neurotoxicity in prion diseases.

October 20, 2020
Review
Open Access

Astrocytes in Tauopathies

Frontiers in Neurology
Matthew J ReidWendy Noble
May 29, 2020
Open Access

Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

ELife
Kirby M DonnellyMargaret M Panning Pearce
June 14, 2020

Metabolomic study of disease progression in scrapie prion infected mice; validation of a novel method for brain metabolite extraction

Metabolomics : Official Journal of the Metabolomic Society
Ze-Lin FuBrian D Sykes
October 20, 2020
Review
Open Access

From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein

Frontiers in Synaptic Neuroscience
Antonio Heras-Garvin, Nadia Stefanova
August 29, 2020
Review
Open Access

Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases

International Journal of Molecular Sciences
Rose Ghemrawi, Mostafa Khair
August 29, 2020
Review
Open Access

Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays

Biomolecules
Matteo Manca, Allison Kraus
October 8, 2020
Review
Open Access

Retinal Degeneration and Alzheimer's Disease: An Evolving Link

International Journal of Molecular Sciences
Ajay AshokRithvik Ayyagari
September 22, 2020
Open Access

Two distinct prions in fatal familial insomnia and its sporadic form

Brain Communications
Atsuko TakeuchiTetsuyuki Kitamoto
September 23, 2020

The prion-like nature of amyotrophic lateral sclerosis

Progress in Molecular Biology and Translational Science
L McAlaryN R Cashman
September 3, 2020
Review
Open Access

N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases

International Journal of Molecular Sciences
Hideyuki Hara, Suehiro Sakaguchi
July 2, 2020
Open Access

Efficient transmission of classical scrapie agent x124 by intralingual route to genetically susceptible sheep with a low dose inoculum

Research in Veterinary Science
Najiba MammadovaJustin J Greenlee
October 3, 2020
Open Access

Sex differences in gene expression with galactosylceramide treatment in Cln3Δex7/8 mice

PloS One
Joelle MakoukjiRose-Mary Boustany
August 29, 2020
Open Access

Advancing medicine for Alzheimer's disease: A plasma neural exosome platform

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Edward J Goetzl

Sign up to follow this feed and discover related papers.

Related Feeds

ALS

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS & FTD: TDP-43

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share a considerable proportion of characteristics including the same neuropathological substrate of abnormally phosphorylated TAR DNA binding protein (TDP-43). Here are the latest discoveries pertaining to ALS, FTD and TDP-43.

ALS - Pathogenic Mechanisms

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

ALS - Phenotypes

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating phenotypes associated with this genetically heterogeneous disorder.

ALS - Stress Granules

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here are the latest discoveries pertaining to this disease.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Age-related Dementia

Age-related dementias present as cognitive decline that is not a part of normal aging. Age-related dementias include Alzheimer's disease, vascular dementia, and Lewy body dementia. Discover the latest research on age-related dementia here.

© 2020 Meta ULC. All rights reserved
/feed-previews/prion-diseases-strain-diversity-and/f43c4f35-2c30-491c-ae3e-f1a5bc9a6e95