Prion Diseases: Strain Diversity & Neurotoxicity

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Distinct prion strains are associated with different prion protein conformations and glycosylation patterns and associate with disease progression and severity. Here is the latest research on strain diversity and neurotoxicity in prion diseases.

October 20, 2020
Review
Open Access

Astrocytes in Tauopathies

Frontiers in Neurology
Matthew J ReidWendy Noble
November 20, 2020
Review

Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective

Cell Death and Differentiation
François Le Guerroué, Richard J Youle
October 30, 2020
Review
Open Access

Ten years of research on synergisms and antagonisms in chemical mixtures: A systematic review and quantitative reappraisal of mixture studies

Environment International
Olwenn MartinAndreas Kortenkamp
October 20, 2020
Review
Open Access

From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein

Frontiers in Synaptic Neuroscience
Antonio Heras-Garvin, Nadia Stefanova
August 29, 2020
Review
Open Access

Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases

International Journal of Molecular Sciences
Rose Ghemrawi, Mostafa Khair
November 17, 2020
Preprint
Open Access

14-3-3s reduce propagation and toxicity of pathologic alpha-synuclein in the in vivo preformed fibril model

BioRxiv : the Preprint Server for Biology
R. UnderwoodTalene A Yacoubian
August 29, 2020
Review
Open Access

Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays

Biomolecules
Matteo Manca, Allison Kraus
November 13, 2020
Review

Emerging potential of cannabidiol in reversing proteinopathies

Ageing Research Reviews
Raju DashIl Soo Moon
October 8, 2020
Review
Open Access

Retinal Degeneration and Alzheimer's Disease: An Evolving Link

International Journal of Molecular Sciences
Ajay AshokRithvik Ayyagari
September 22, 2020
Open Access

Two distinct prions in fatal familial insomnia and its sporadic form

Brain Communications
Atsuko TakeuchiTetsuyuki Kitamoto
October 18, 2020
Open Access

The Effects of Divalent Cation-Chelated Prion Fibrils on the Immune Response of EOC 13.31 Microglia Cells

Cells
Huan-I JenCheng-I Lee
September 23, 2020

The prion-like nature of amyotrophic lateral sclerosis

Progress in Molecular Biology and Translational Science
L McAlaryN R Cashman
September 3, 2020
Review
Open Access

N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases

International Journal of Molecular Sciences
Hideyuki Hara, Suehiro Sakaguchi
November 4, 2020

Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis

European Journal of Medicinal Chemistry
Elisa Rojas-PratsAna Martinez
August 30, 2020
Open Access

Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy

Acta Neuropathologica Communications
Allison J SchaserVivek K Unni
October 3, 2020
Open Access

Sex differences in gene expression with galactosylceramide treatment in Cln3Δex7/8 mice

PloS One
Joelle MakoukjiRose-Mary Boustany
August 29, 2020
Open Access

Advancing medicine for Alzheimer's disease: A plasma neural exosome platform

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Edward J Goetzl

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