Prion Diseases: Strain Diversity & Neurotoxicity

Misfolded prion proteins characterize a number of fatal neurodegenerative diseases. Distinct prion strains are associated with different prion protein conformations and glycosylation patterns and associate with disease progression and severity. Here is the latest research on strain diversity and neurotoxicity in prion diseases.

August 15, 2021

The aminoglycoside G418 hinders de novo prion infection in cultured cells.

The Journal of Biological Chemistry
Hamza ArshadJoel C Watts
May 14, 2021
Open Access

The degree of astrocyte activation is predictive of the incubation time to prion disease.

Acta Neuropathologica Communications
Natallia MakaravaIlia V Baskakov
April 3, 2021
Review
Open Access

Neuropathology of Animal Prion Diseases.

Biomolecules
Leonor OrgeMaria Dos Anjos Pires
February 19, 2021
Open Access

Site-specific analysis of N-glycans from different sheep prion strains.

PLoS Pathogens
Natali NakićGiuseppe Legname
June 21, 2020
Open Access

An astrocyte cell line that differentially propagates murine prions.

The Journal of Biological Chemistry
Waqas TahirHermann M Schatzl
June 10, 2020
Open Access

Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination.

The Journal of Biological Chemistry
Hae-Eun KangGlenn C Telling
June 3, 2020
Open Access

Posttranslational modifications define course of prion strain adaptation and disease phenotype.

The Journal of Clinical Investigation
Natallia MakaravaIlia V Baskakov
May 27, 2020
Open Access

Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease.

Neurobiology of Disease
Julia A CallenderChristina J Sigurdson
April 18, 2020
Open Access

Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease

Brain : a Journal of Neurology
Ilaria VanniRomolo Nonno
April 3, 2020
Open Access

NMDA Receptor and L-Type Calcium Channel Modulate Prion Formation.

Cellular and Molecular Neurobiology
Marco ZattoniGiuseppe Legname
January 28, 2020
Open Access

Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease.

The Journal of Clinical Investigation
Alejandro M SevillanoChristina J Sigurdson
November 7, 2019
Preprint
Open Access

Loss of region-specific glial homeostatic signature in prion diseases

ResearchSquare
Natallia MakaravaIlia V Baskakov
October 30, 2019
Preprint
Open Access

Loss of region-specific glial homeostatic signature in prion diseases

BioRxiv : the Preprint Server for Biology
Natallia MakaravaIlia V Baskakov
October 28, 2019
Open Access

Region-Specific Response of Astrocytes to Prion Infection

Frontiers in Neuroscience
Natallia MakaravaIlia V Baskakov
September 26, 2019
Open Access

Discrimination of Prion Strain Targeting in the Central Nervous System via Reactive Astrocyte Heterogeneity in CD44 Expression

Frontiers in Cellular Neuroscience
Barry M BradfordNeil A Mabbott
September 25, 2019
Open Access

A New Cell Model for Investigating Prion Strain Selection and Adaptation

Viruses
Alexandra PhiliastidesPeter-Christian Klöhn

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