Proinsulin & Type 2 Diabetes

Proinsulin, a prohormone precursor to insulin, is produced in beta cells of pancreatic islets. Here is the latest research on proinsulin in type 2 diabetes.

January 16, 2022

A pro-endocrine pancreatic islet transcriptional program established during development is retained in human gallbladder epithelial cells.

Cellular and Molecular Gastroenterology and Hepatology
Mugdha V JoglekarAnandwardhan A Hardikar
January 13, 2022

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
Yuka OkajimaHitoshi Shimano
January 13, 2022

Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine induced cell death.

The Journal of Endocrinology
Maria KarsaiPhilipp A Gerber
January 13, 2022

Mapping the cord blood transcriptome of pregnancies affected by early maternal anemia to identify signatures of fetal programming.

The Journal of Clinical Endocrinology and Metabolism
Gad HatemRashmi B Prasad
January 12, 2022
Review
Open Access

Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion.

International Journal of Molecular Sciences
Lucie Oberhauser, Pierre Maechler
January 12, 2022
Review

Inter-organ Crosstalk in Pancreatic Islet Function and Pathology.

FEBS Letters
Ronald M Evans, Zong Wei
January 8, 2022

Practical Clinical Applications of Islet Autoantibody Testing in Type 1 Diabetes.

The Journal of Applied Laboratory Medicine
William E WinterIshwarlal Jialal
January 7, 2022

The correlation between amylin and insulin by treatment with 2-deoxy-D-glucose and/or mannose in rat insulinoma ins-1E cells.

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
H S KimY-M Yoo
January 7, 2022

Central Nervous System Control of Glucose Homeostasis: A Therapeutic Target for Type 2 Diabetes?

Annual Review of Pharmacology and Toxicology
Zaman MirzadehMichael W Schwartz
January 6, 2022
Review

Using adipose-derived mesenchymal stem cells to fight the metabolic complications of obesity: Where do we stand?

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
Agnieszka MikłoszAdrian Chabowski
January 4, 2022
Preprint
Open Access

High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets

BioRxiv : the Preprint Server for Biology
H. J. MacMillanAthma A Pai
January 4, 2022

Differentiation of Human Pluripotent Stem Cells into Pancreatic Beta-cell Precursors in a 2D Culture System.

Journal of Visualized Experiments : JoVE
Bushra Memon, Essam M Abdelalim
December 31, 2021
Review
Open Access

Mechanisms Underlying the Antidiabetic Activities of Polyphenolic Compounds: A Review.

Frontiers in Pharmacology
Tina Nie, Garth J S Cooper

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