Proinsulin & Type 2 Diabetes

Proinsulin, a prohormone precursor to insulin, is produced in beta cells of pancreatic islets. Here is the latest research on proinsulin in type 2 diabetes.

January 17, 2021
Open Access

The Cardiolipin Transacylase Tafazzin Regulates Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets from Mice

BioRxiv : the Preprint Server for Biology
L. K. ColeGrant Hatch
January 10, 2021

Insulin resistance in congenital adrenal hyperplasia is compensated for by reduced insulin clearance

The Journal of Clinical Endocrinology and Metabolism
Daniel Minutti de OliveiraBruno Geloneze
January 12, 2021
Open Access

Roles of oxidative stress, apoptosis, and inflammation in metal-induced dysfunction of beta pancreatic cells isolated from CD1 mice

Saudi Journal of Biological Sciences
Huda Al DoghaitherJihan Ghulam
January 16, 2021
Open Access

The Chemical Constituents from Fruits of Catalpa bignonioides Walt. and Their α-Glucosidase Inhibitory Activity and Insulin Secretion Effect

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Youngse OhKi Sung Kang
January 13, 2021

Antidiabetic and antioxidant activity of phlorotannins extracted from the brown seaweed Cystoseira compressa in streptozotocin-induced diabetic rats

Environmental Science and Pollution Research International
Saly GhedaAbeer Khamis
January 16, 2021

Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis

Journal of Medicinal Chemistry
Brandon T MillikenRobert P Doyle
January 11, 2021
Open Access

Mitofusins 1 and 2 collaborate to fuel pancreatic beta cell insulin release via regulation of both mitochondrial structure and DNA content

BioRxiv : the Preprint Server for Biology
V. SidaralaScott A Soleimanpour
December 24, 2020

Pharmacological Targeting of Endoplasmic Reticulum Stress in Pancreatic Beta Cells

Trends in Pharmacological Sciences
Sara BilekovaHeiko Lickert
January 14, 2021
Open Access

Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance

International Journal of Molecular Sciences
Carine BeaupereGhislaine Guillemain
January 15, 2021

Beta-cell function and human islet transplantation: can we improve?

The Journal of Endocrinology
Jennifer Chen, Jenny E Gunton
January 16, 2021

SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells

Genes & Development
Romina J BevacquaSeung K Kim
January 12, 2021

Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes

Chemical Reviews
Danilo MilardiAyyalusamy Ramamoorthy
January 12, 2021
Open Access

Optimization of a Method to Detect Autoantigen-Specific T-Cell Responses in Type 1 Diabetes

Frontiers in Immunology
Yassmin MusthaffaRanjeny Thomas

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