PROTACs

Protacs, which induce selective degradation of their target protein via the ubiquitin-proteasome system, are useful for the down-regulation of various proteins, including disease-related proteins and epigenetic proteins. Here is the latest research on protacs.

May 4, 2020

Development of small-molecule BRD4 degraders based on pyrrolopyridone derivative

Bioorganic Chemistry
Jian ZhangHuibin Zhang
May 15, 2020
Review

Using Chemical Epigenetics to Target Cancer

Molecular Cell
Virangika K WimalasenaJun Qi
June 11, 2020

Scaffold hopping enables direct access to more potent PROTACs with in vivo activity

Chemical Communications : Chem Comm
George M BurslemCraig M Crews
May 15, 2020
Review
Open Access

Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

Journal of Hematology & Oncology
Xin Li, Yongcheng Song
June 9, 2020

The application of ubiquitin ligases in the PROTAC drug design

Acta Biochimica Et Biophysica Sinica
Yilin Chen, Jianping Jin
May 22, 2020

Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein

Journal of Medicinal Chemistry
Mingliang WangShaomeng Wang
April 26, 2020
Open Access

Ubiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activity

Biochimica Et Biophysica Acta. Molecular Cell Research
Seung-Joo YangKwang Min Lee
April 28, 2020
Open Access

Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

ACS Chemical Biology
Marı A ManeiroEdward W Tate
May 1, 2020
Open Access

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

Cells
Ivana GasicTimothy J Mitchison
May 18, 2020
Review
Open Access

Emerging New Concepts of Degrader Technologies

Trends in Pharmacological Sciences
Yu DingBoxun Lu
June 20, 2020
Comment / Editorial
Open Access

PROTAC Compounds Targeting TRK for Use in Cancer Therapeutics

ACS Medicinal Chemistry Letters
Robert B Kargbo
June 2, 2020
Review

PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics

Oncogene
Sajid KhanDaohong Zhou
June 12, 2020
Open Access

Molecular mechanisms of thalidomide and its derivatives

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Takumi Ito, Hiroshi Handa
May 21, 2020

Medicinal Chemistry Strategies for the Development of Kinase Inhibitors Targeting Point Mutations

Journal of Medicinal Chemistry
Xiaoyun LuKe Ding
May 20, 2020

Prey for the Proteasome: Targeted Protein Degradation - A Medicinal Chemist´s Perspective

Angewandte Chemie
Laura M LuhPhilipp M Cromm

Sign up to follow this feed and discover related papers.

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

© 2020 Meta ULC. All rights reserved
/feed-previews/protacs/78aa96e6-c738-452b-b038-307b617d5326