PROTACs

Protacs, which induce selective degradation of their target protein via the ubiquitin-proteasome system, are useful for the down-regulation of various proteins, including disease-related proteins and epigenetic proteins. Here is the latest research on protacs.

October 23, 2020
Open Access

First small-molecule PROTACs for G protein-coupled receptors: inducing α1A -adrenergic receptor degradation

Acta Pharmaceutica Sinica. B
Zhenzhen LiMinyong Li
October 28, 2020

RNA-PROTACs - degraders of RNA-binding proteins

Angewandte Chemie
Alice GhidiniJonathan Hall
September 16, 2020
Open Access

Degrading AR-Dependent Cancers: Expanding the Role of PROTACs

Neoplasia : an International Journal for Oncology Research
Anna R Michmerhuizen, Corey Speers
September 6, 2020
Comment / Editorial
Open Access

Could PROTACs Protect Us From COVID-19?

Drug Discovery Today
Wilnelly Martinez-Ortiz, Ming-Ming Zhou
October 2, 2020
Open Access

Targeted Protein Degradation as a Promising Tool for Epigenetic Upregulation of Fetal Hemoglobin

ChemMedChem
Thijs C J VerheulSjaak Philipsen
September 25, 2020
Open Access

Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC)

European Journal of Medicinal Chemistry
Fangyuan CaoFrank J Dekker
September 15, 2020
Open Access

Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors

Exploration of Targeted Anti-tumor Therapy
Rachael ArthurGraham Packham
September 29, 2020
Review
Open Access

Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs

Frontiers in Oncology
Shuhua Zheng, Wensi Tao
September 15, 2020

Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of PARP1 for Treating Cancers

Journal of Medicinal Chemistry
Chao-Guo CaoYuanwei Chen
September 5, 2020

Discovery of potent small molecule PROTACs targeting mutant EGFR

European Journal of Medicinal Chemistry
Hong-Yi ZhaoSan-Qi Zhang
September 6, 2020

Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation

Cell Chemical Biology
Jing ZhangXuedong Dai
October 6, 2020

Automated Design of Macrocycles for Therapeutic Applications: From Small Molecules to Peptides and Proteins

Journal of Medicinal Chemistry
Dan SindhikaraAndreas Evers
October 5, 2020
Preprint
Open Access

Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer

ChemRxiv
Hidetomo YokooYosuke Demizu
September 3, 2020
Review
Open Access

Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives

Acta Pharmaceutica Sinica. B
Yuan FangBin Yu
October 27, 2020

Charting a New Path Towards Degrading Every Protein

Chembiochem : a European Journal of Chemical Biology
Behnam Nabet
October 5, 2020
Preprint
Open Access

Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer

ChemRxiv
Hidetomo YokooYosuke Demizu
September 18, 2020
Open Access

Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

ACS Medicinal Chemistry Letters
Victoria G KleinR Scott Lokey
September 27, 2020
Open Access

The therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells

Cell Death & Disease
An-Cheng QinXing-Sheng Lu

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