Protacs, which induce selective degradation of their target protein via the ubiquitin-proteasome system, are useful for the down-regulation of various proteins, including disease-related proteins and epigenetic proteins. Here is the latest research on protacs.

May 4, 2020

Development of small-molecule BRD4 degraders based on pyrrolopyridone derivative

Bioorganic Chemistry
Jian ZhangHuibin Zhang
May 15, 2020

Using Chemical Epigenetics to Target Cancer

Molecular Cell
Virangika K WimalasenaJun Qi
June 11, 2020

Scaffold hopping enables direct access to more potent PROTACs with in vivo activity

Chemical Communications : Chem Comm
George M BurslemCraig M Crews
May 15, 2020
Open Access

Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

Journal of Hematology & Oncology
Xin Li, Yongcheng Song
June 9, 2020

The application of ubiquitin ligases in the PROTAC drug design

Acta Biochimica Et Biophysica Sinica
Yilin Chen, Jianping Jin
May 22, 2020

Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein

Journal of Medicinal Chemistry
Mingliang WangShaomeng Wang
April 26, 2020
Open Access

Ubiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activity

Biochimica Et Biophysica Acta. Molecular Cell Research
Seung-Joo YangKwang Min Lee
April 28, 2020
Open Access

Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

ACS Chemical Biology
Marı A ManeiroEdward W Tate
May 1, 2020
Open Access

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

Ivana GasicTimothy J Mitchison
May 18, 2020
Open Access

Emerging New Concepts of Degrader Technologies

Trends in Pharmacological Sciences
Yu DingBoxun Lu
June 20, 2020
Comment / Editorial
Open Access

PROTAC Compounds Targeting TRK for Use in Cancer Therapeutics

ACS Medicinal Chemistry Letters
Robert B Kargbo
June 2, 2020

PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics

Sajid KhanDaohong Zhou
June 12, 2020
Open Access

Molecular mechanisms of thalidomide and its derivatives

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Takumi Ito, Hiroshi Handa
May 21, 2020

Medicinal Chemistry Strategies for the Development of Kinase Inhibitors Targeting Point Mutations

Journal of Medicinal Chemistry
Xiaoyun LuKe Ding
May 20, 2020

Prey for the Proteasome: Targeted Protein Degradation - A Medicinal Chemist´s Perspective

Angewandte Chemie
Laura M LuhPhilipp M Cromm

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