Protein Localization in Disease & Therapy

Localization of proteins is critical for ensuring the correct location for physiological functioning. If an error occurs, diseases such as cardiovascular, neurodegenerative disorders and cancers can present. Therapies are being explored to target this mislocalization. Here is the latest research on protein localization in disease and therapy.

February 22, 2021
Open Access

Chemical rescue of mutant proteins in living cells by naturally occurring small molecules

BioRxiv : the Preprint Server for Biology
D. S. HassellMichael A McMurray
February 16, 2021
Open Access

The Heart of the Alzheimer's: A Mindful View of Heart Disease.

Frontiers in Physiology
Alessandro EvangelistiFederica Del Monte
February 13, 2021
Open Access

Post-Translational Modifications That Drive Prostate Cancer Progression.

Ivana Samaržija
February 7, 2021

Amyotrophic lateral sclerosis-associated VAP33 is required for maintaining neuronal dendrite morphology and organelle distribution in Drosophila.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Kosuke KamemuraTakahiro Chihara
February 6, 2021

Endoplasmic reticulum stress: a key regulator of the follicular microenvironment in the ovary.

Molecular Human Reproduction
Miyuki HaradaYutaka Osuga
January 29, 2021

De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis.

American Journal of Human Genetics
Patricia L WengSimone Sanna-Cherchi
January 26, 2021
Open Access

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation.

Frontiers in Neurology
Carolina AlquezarAimee W Kao
January 13, 2021
Open Access

Using stable isotope labeling to advance our understanding of Alzheimer's disease etiology and pathology.

Journal of Neurochemistry
Timothy J Hark, Jeffrey N Savas
January 12, 2021

Disulfiram: a novel repurposed drug for cancer therapy

Cancer Chemotherapy and Pharmacology
Chen LuXiao Zhang
January 8, 2021
Open Access

DNA-Histone Cross-Links: Formation and Repair

Frontiers in Cell and Developmental Biology
Manideep C PachvaRegina Groisman
January 8, 2021

Endoplasmic reticulum stress: a key regulator of the follicular microenvironment in the ovary

Molecular Human Reproduction
Miyuki HaradaYutaka Osuga
January 6, 2021
Open Access

Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

Nature Communications
Bikshapathi JaggaJade K Forwood
January 6, 2021

Build-UPS and break-downs: metabolism impacts on proteostasis and aging.

Cell Death and Differentiation
Franziska OttensThorsten Hoppe

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