Protein Localization in Disease & Therapy

Localization of proteins is critical for ensuring the correct location for physiological functioning. If an error occurs, diseases such as cardiovascular, neurodegenerative disorders and cancers can present. Therapies are being explored to target this mislocalization. Here is the latest research on protein localization in disease and therapy.

September 11, 2019

In vivo functionalization of diatom biosilica with sodium alendronate as osteoactive material

Materials Science & Engineering. C, Materials for Biological Applications
Stefania R CiccoGianluca M Farinola
November 30, 2018
Open Access

Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi

Frontiers in Cellular and Infection Microbiology
Shama MujawarChandrajit Lahiri
May 28, 2019
Review
Open Access

Dysfunction of Cellular Proteostasis in Parkinson's Disease

Frontiers in Neuroscience
Šárka LehtonenJari Koistinaho
January 18, 2019
Open Access

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

Nature
Steve StegenGeert Carmeliet
May 23, 2019
Open Access

A highly ordered, nonprotective MALAT1 ENE structure is adopted prior to triplex formation

RNA
Michael J Yonkunas, Nathan J Baird
August 17, 2020

Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention

Progress in Neurobiology
Chiara LanzillottaFabio Di Domenico
January 16, 2019
Open Access

Exploiting locational and topological overlap model to identify modules in protein interaction networks

BMC Bioinformatics
Lixin ChengKwong-Sak Leung
September 14, 2019
Open Access

Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells

Archives of Toxicology
Durr-E-Shahwar MalikNigel J Gooderham
February 14, 2019
Preprint
Open Access

Genome-wide association study identifies 44 independent genomic loci for self-reported adult hearing difficulty in the UK Biobank cohort

BioRxiv : the Preprint Server for Biology
Helena Rose Rees WellsFrances MK Wiliams
June 9, 2020
Preprint

An in silico map of the SARS-CoV-2 RNA Structurome

BioRxiv : the Preprint Server for Biology
Ryan J AndrewsWalter N Moss
July 26, 2019
Open Access

Nonnative structure in a peptide model of the unfolded state of superoxide dismutase 1 (SOD1): Implications for ALS-linked aggregation

The Journal of Biological Chemistry
Noah R CohenC Robert Matthews
November 20, 2019
Review
Open Access

Proteostasis In The Endoplasmic Reticulum: Road to Cure

Cancers
Su Min Nam, Young Joo Jeon
September 14, 2019
Preprint
Open Access

Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease

BioRxiv : the Preprint Server for Biology
Salvatore LoguercioWilliam E Balch
June 5, 2020
Open Access

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases

Quarterly Reviews of Biophysics
Tessa SinnigeMichele Vendruscolo
April 13, 2019
Review

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas

Advances in Medical Sciences
Jan LukasMatthias Sendler
February 20, 2020
Review

The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic intervention

Environmental Science and Pollution Research International
Abdelmagid M ElmatbolyMohamed M Abdel-Daim

Sign up to follow this feed and discover related papers.

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Biosensors for Cancer Detection

Biosensors are devices that are designed to detect a specific biological analyte by essentially converting a biological entity (ie, protein, DNA, RNA) into an electrical signal that can be detected and analyzed. The use of biosensors in cancer detection and monitoring holds vast potential. Biosensors can be designed to detect emerging cancer biomarkers and to determine drug effectiveness at various target sites. Biosensor technology has the potential to provide fast and accurate detection, reliable imaging of cancer cells, and monitoring of angiogenesis and cancer metastasis, and the ability to determine the effectiveness of anticancer chemotherapy agents.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

CAR-T cells

Chimeric antigen receptor (CAR) T cells are cells that are genetically engineered to recognize and target specific proteins. The ability of these cells to recognize cancer antigens and eliminate tumor cells have transformed cancer immunotherapy approaches. Here is the latest research on CAR-T cells.

Cancer Cell Invasion: Nanomedicine

Nanomedicine is a promising alternative for cancer detection and therapy that utilizes nanoparticles, such as liposomes. Nanoparticles can potentially target cancer cell invasion and metastasis. Discover the latest research on Cancer Cell Invasion: Nanomedicine here.

Cancer Disparities

Cancer disparities refers to differences in cancer outcomes (e.g., number of cancer cases, related health complications) across population groups.

Cancer Genomics

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.

Cancer Immunotherapy

Cancer immunotherapy is an important field of research that is looking at controlling cancer and tumor growth by activating the individuals own immune system. Recent studies have utilized chimeric antigen receptor t-cell therapy, immune checkpoint inhibitors and neoantigen vaccines. Discover the latest research on cancer immunotherapy here.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

© 2020 Meta ULC. All rights reserved
/feed-previews/protein-localization-in-disease/495db04f-3878-4a8b-8801-f48a72184905