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Protein Localization in Disease & Therapy

Protein Localization in Disease & Therapy diagram by Katsuhisa Masaki et al.
Katsuhisa Masaki et al.

Localization of proteins is critical for ensuring the correct location for physiological functioning. If an error occurs, diseases such as cardiovascular, neurodegenerative disorders and cancers can present. Therapies are being explored to target this mislocalization. Here is the latest research on protein localization in disease and therapy.

Top 20 most recent papers

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

NatureJanuary 16, 2019
Steve StegenGeert Carmeliet
Acta Neuropathologica

RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas

Acta NeuropathologicaMay 8, 2019
Peter WirthschaftBjörn Tews

Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease

bioRxivSeptember 14, 2019
Salvatore LoguercioWilliam E. Balch
American Journal of Human Genetics

GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank

American Journal of Human GeneticsOctober 1, 2019
Helena Rose Rees WellsFrances M K Williams

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

CancersAugust 21, 2019
Nicholas F Brown, John F Marshall

Adrenergic Regulation of Drp1-Driven Mitochondrial Fission in Cardiac Physio-Pathology

AntioxidantsDecember 18, 2018
Bong Sook JhunYisang Yoon
Materials Science & Engineering. C, Materials for Biological Applications

In vivo functionalization of diatom biosilica with sodium alendronate as osteoactive material

Materials Science & Engineering. C, Materials for Biological ApplicationsSeptember 11, 2019
Stefania Roberta CiccoGianluca Maria Farinola

A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry

MBioJuly 9, 2019
J Maximilian FelsKartik Chandran
International Journal of Molecular Sciences

Function and Transcriptional Regulation of Bovine TORC2 Gene in Adipocytes: Roles of C/EBP , XBP1 , INSM1 and ZNF263

International Journal of Molecular SciencesSeptember 4, 2019
Rajwali KhanZan Linsen
JAMA Surgery

Breast Cancer Recurrence in the Nipple-Areola Complex After Nipple-Sparing Mastectomy With Immediate Breast Reconstruction for Invasive Breast Cancer

JAMA SurgeryAugust 28, 2019
Zhen-Yu WuBeomSeok Ko

The Unsolved Puzzle of c-Rel in B Cell Lymphoma

CancersJuly 4, 2019
Maike Kober-Hasslacher, Marc Schmidt-Supprian
International Journal of Molecular Sciences

Molecular Mechanisms and Determinants of Innovative Correction Approaches in Coagulation Factor Deficiencies

International Journal of Molecular SciencesJune 21, 2019
Dario Balestra, Alessio Branchini
International Journal of Molecular Sciences

SUSD2 Proteolytic Cleavage Requires the GDPH Sequence and Inter-Fragment Disulfide Bonds for Surface Presentation of Galectin-1 on Breast Cancer Cells

International Journal of Molecular SciencesAugust 5, 2019
Mitch E Patrick, Kristi A Egland
Nature Immunology

Targeting immune cell circuits and trafficking in inflammatory bowel disease

Nature ImmunologyJune 27, 2019
Markus Friedrich Neurath
Journal of Experimental & Clinical Cancer Research : CR

β-Catenin nuclear localization positively feeds back on EGF/EGFR-attenuated AJAP1 expression in breast cancer

Journal of Experimental & Clinical Cancer Research : CRJune 6, 2019
Cong XuYun Niu
Breast Cancer Research : BCR

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Breast Cancer Research : BCRApril 3, 2019
Junmei CairnsLiewei Wang
Journal of Neuroinflammation

Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a role in descending pain facilitation

Journal of NeuroinflammationJanuary 3, 2019
Hua-dong NiMing Yao
International Journal of Molecular Sciences

Fine Tuning: Effects of Post-Translational Modification on Hsp70 Chaperones

International Journal of Molecular SciencesAugust 28, 2019
Alijah A Griffith, William E Holmes
Advances in Medical Sciences

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas

Advances in Medical SciencesApril 9, 2019
Jan LukasMatthias Sendler
Cancer Cell International

Interaction between 17β-estradiol, prolactin and human papillomavirus induce E6/E7 transcript and modulate the expression and localization of hormonal receptors

Cancer Cell InternationalSeptember 2, 2019
Inocencia Guadalupe Ramírez-LópezAna Laura Pereira-Suárez

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