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Protein Localization in Disease & Therapy

Protein Localization in Disease & Therapy diagram by Masaki et al, PLOS Pathogens
Masaki et al, PLOS Pathogens

Localization of proteins is critical for ensuring the correct location for physiological functioning. If an error occurs, diseases such as cardiovascular, neurodegenerative disorders and cancers can present. Therapies are being explored to target this mislocalization. Here is the latest research on protein localization in disease and therapy.

Top 20 most recent papers
JAMA Surgery

Breast Cancer Recurrence in the Nipple-Areola Complex After Nipple-Sparing Mastectomy With Immediate Breast Reconstruction for Invasive Breast Cancer

JAMA SurgeryAugust 29, 2019
Zhen-Yu WuBeomSeok Ko

DeepMito: accurate prediction of protein sub-mitochondrial localization using convolutional neural networks

BioinformaticsJune 21, 2019
Castrense SavojardoRita Casadio
American Journal of Human Genetics

GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank

American Journal of Human GeneticsOctober 1, 2019
Helena R R WellsFrances M K Williams

Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease

bioRxivSeptember 14, 2019
Salvatore LoguercioWilliam E Balch
Journal of the American Chemical Society

Interplay of guanine oxidation and G-quadruplex folding in gene promoters

Journal of the American Chemical SocietyDecember 28, 2019
Aaron M Fleming, Cynthia J Burrows

A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry

MBioJuly 11, 2019
J Maximilian FelsKartik Chandran
Carbohydrate Research

Dermatan sulfate epimerase 1 expression and mislocalization may interfere with dermatan sulfate synthesis and breast cancer cell growth

Carbohydrate ResearchJanuary 24, 2020
Eduardo ListikLeny Toma

HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53

Neuro-oncologyNovember 12, 2019
Caroline CapdevielleMartin Hagedorn
BMC Oral Health

Overexpression of Epstein-Barr virus-encoded latent membrane protein-1 (LMP-1) in oral squamous cell carcinoma

BMC Oral HealthJuly 12, 2019
Rifat RahmanWaranun Buajeeb
Cancer Cell International

Interaction between 17β-estradiol, prolactin and human papillomavirus induce E6/E7 transcript and modulate the expression and localization of hormonal receptors

Cancer Cell InternationalSeptember 12, 2019
Inocencia Guadalupe Ramírez-LópezAna Laura Pereira-Suárez

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

CancersAugust 24, 2019
Nicholas F Brown, John F Marshall
Trends in Cancer

DUBs, Hypoxia, and Cancer

Trends in CancerNovember 11, 2019
Daniela MennerichThomas Kietzmann
World Journal of Biological Chemistry

Complex interactomes and post-translational modifications of the regulatory proteins HABP4 and SERBP1 suggest pleiotropic cellular functions

World Journal of Biological ChemistryNovember 27, 2019
Carolina ColletiJörg Kobarg
BMC Medical Genomics

Stoichioproteomics reveal oxygen usage bias, key proteins and pathways in glioma

BMC Medical GenomicsAugust 30, 2019
Yongqin YinYu-Juan Zhang

S-Nitrosylation: An Emerging Paradigm of Redox Signaling

AntioxidantsSeptember 20, 2019
Veani FernandoSaori Furuta
Disease Markers

Intratumoral Heterogeneity Determines the Expression of mTOR-pathway Proteins in Prostate Cancer

Disease MarkersDecember 31, 2019
Giorgio Ivan RussoTilman Todenhöfer
The Journal of Biological Chemistry

Nonnative structure in a peptide model of the unfolded state of superoxide dismutase 1 (SOD1): Implications for ALS-linked aggregation

The Journal of Biological ChemistryJuly 26, 2019
Noah R CohenC Robert Matthews
Genes & Diseases

Regulation of the Hippo signaling pathway by deubiquitinating enzymes in cancer

Genes & DiseasesDecember 14, 2019
Ashley MussellJianmin Zhang
Current Aging Science

Telomerase Biology Associations offer Keys to Cancer and Aging Therapeutics

Current Aging ScienceSeptember 24, 2019
Joan Smith Sonneborn
Advances in Protein Chemistry and Structural Biology

Protein misfolding in endoplasmic reticulum stress with applications to renal diseases

Advances in Protein Chemistry and Structural BiologyJanuary 14, 2020
Samera Nademi, Jeffrey G Dickhout

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