Protein Localization in Disease & Therapy

Localization of proteins is critical for ensuring the correct location for physiological functioning. If an error occurs, diseases such as cardiovascular, neurodegenerative disorders and cancers can present. Therapies are being explored to target this mislocalization. Here is the latest research on protein localization in disease and therapy.

September 11, 2019

In vivo functionalization of diatom biosilica with sodium alendronate as osteoactive material

Materials Science & Engineering. C, Materials for Biological Applications
Stefania R CiccoGianluca M Farinola
November 30, 2018
Open Access

Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi

Frontiers in Cellular and Infection Microbiology
Shama MujawarChandrajit Lahiri
May 28, 2019
Open Access

Dysfunction of Cellular Proteostasis in Parkinson's Disease

Frontiers in Neuroscience
Šárka LehtonenJari Koistinaho
January 18, 2019
Open Access

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

Steve StegenGeert Carmeliet
May 23, 2019
Open Access

A highly ordered, nonprotective MALAT1 ENE structure is adopted prior to triplex formation

Michael J Yonkunas, Nathan J Baird
August 17, 2020

Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention

Progress in Neurobiology
Chiara LanzillottaFabio Di Domenico
January 16, 2019
Open Access

Exploiting locational and topological overlap model to identify modules in protein interaction networks

BMC Bioinformatics
Lixin ChengKwong-Sak Leung
September 14, 2019
Open Access

Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells

Archives of Toxicology
Durr-E-Shahwar MalikNigel J Gooderham
February 14, 2019
Open Access

Genome-wide association study identifies 44 independent genomic loci for self-reported adult hearing difficulty in the UK Biobank cohort

BioRxiv : the Preprint Server for Biology
Helena Rose Rees WellsFrances MK Wiliams
June 9, 2020

An in silico map of the SARS-CoV-2 RNA Structurome

BioRxiv : the Preprint Server for Biology
Ryan J AndrewsWalter N Moss
July 26, 2019
Open Access

Nonnative structure in a peptide model of the unfolded state of superoxide dismutase 1 (SOD1): Implications for ALS-linked aggregation

The Journal of Biological Chemistry
Noah R CohenC Robert Matthews
November 20, 2019
Open Access

Proteostasis In The Endoplasmic Reticulum: Road to Cure

Su Min Nam, Young Joo Jeon
September 14, 2019
Open Access

Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease

BioRxiv : the Preprint Server for Biology
Salvatore LoguercioWilliam E Balch
June 5, 2020
Open Access

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases

Quarterly Reviews of Biophysics
Tessa SinnigeMichele Vendruscolo
April 13, 2019

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas

Advances in Medical Sciences
Jan LukasMatthias Sendler
February 20, 2020

The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic intervention

Environmental Science and Pollution Research International
Abdelmagid M ElmatbolyMohamed M Abdel-Daim

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