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Proteostasis

Proteostasis diagram by Mcp25, Wikimedia
Mcp25, Wikimedia

Proteostasis enables the maintenance of protein homeostasis via modulation of protein translation, enhancement of chaperone capacity and the prompt clearance of misfolded proteins. It is affected in several neurodegenerative diseases. Here is the latest research.

Top 20 most recent papers
Nature Human Behaviour

Clustering of health, crime and social-welfare inequality in 4 million citizens from two nations

Nature Human BehaviourJanuary 22, 2020
Leah S Richmond-RakerdTerrie E Moffitt
JAMA : the Journal of the American Medical Association

Effect of Renal Denervation and Catheter Ablation vs Catheter Ablation Alone on Atrial Fibrillation Recurrence Among Patients With Paroxysmal Atrial Fibrillation and Hypertension: The ERADICATE-AF Randomized Clinical Trial

JAMA : the Journal of the American Medical AssociationJanuary 22, 2020
Jonathan S SteinbergAlexander B Romanov
Human Molecular Genetics

Naturally occurring NOTCH3 exon skipping attenuates NOTCH3 protein aggregation and disease severity in CADASIL patients

Human Molecular GeneticsJanuary 22, 2020
Gido GravesteijnJulie W Rutten
Current Biology : CB

Delineating the Rules for Structural Adaptation of Membrane-Associated Proteins to Evolutionary Changes in Membrane Lipidome

Current Biology : CBJanuary 21, 2020
Maria MakarovaSnezhana Oliferenko
30
Journal of Human Genetics

Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function

Journal of Human GeneticsJanuary 22, 2020
Qiuju DingHuimei Chen
Neurology

Author response: Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

NeurologyJanuary 22, 2020
Alberto J EspayJames B Leverenz
PLoS Neglected Tropical Diseases

Assessing the impact of aggregating disease stage data in model predictions of human African trypanosomiasis transmission and control activities in Bandundu province (DRC)

PLoS Neglected Tropical DiseasesJanuary 22, 2020
María Soledad CastañoNakul Chitnis
Inorganic Chemistry

Self-Assembly of Porphyrin-Containing Metalla-Assemblies and Cancer Photodynamic Therapy

Inorganic ChemistryJanuary 22, 2020
Xin JiangPeter J Stang
Neurology

Reader response: Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

NeurologyJanuary 22, 2020
Peter Nelson
Communications Biology

Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro

Communications BiologyJanuary 22, 2020
Gefei ChenJan Johansson
Autophagy

Mechanistic insights in recov-ER-phagy: micro-ER-phagy to recover from stress

AutophagyJanuary 22, 2020
Marisa Loi, Maurizio Molinari
Nucleic Acids Research

rRNA expansion segment 27Lb modulates the factor recruitment capacity of the yeast ribosome and shapes the proteome

Nucleic Acids ResearchJanuary 22, 2020
Vaishnavi ShankarNorbert Polacek
Chemistry : a European Journal

Reassessment of an Innovative Insulin Analogue Excludes Protracted Action yet Highlights Distinction between External and Internal Diselenide Bridges

Chemistry : a European JournalJanuary 21, 2020
Michael WeissNorman Metanis
1
Experimental Hematology

Panobinostat and venetoclax enhance the cytotoxicity of gemcitabine, busulfan, and melphalan in multiple myeloma cells

Experimental HematologyJanuary 19, 2020
Benigno C ValdezBorje S Andersson
2
Human Molecular Genetics

Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease

Human Molecular GeneticsJanuary 22, 2020
Jonasz J WeberJeannette Hübener-Schmid
Nucleic Acids Research

The most abundant maternal lncRNA Sirena1 acts post-transcriptionally and impacts mitochondrial distribution

Nucleic Acids ResearchJanuary 21, 2020
Sravya GaneshPetr Svoboda
10
The British Journal of Ophthalmology

Outcomes in randomised controlled trials of multifocal lenses in cataract surgery: the case for development of a core outcome set

The British Journal of OphthalmologyJanuary 22, 2020
Jennifer R EvansMartin D Leyland
bioRxiv

Compressive Big Data Analytics: An Ensemble Meta-Algorithm for High-dimensional Multisource Datasets

bioRxivJanuary 20, 2020
Simeone MarinoIvo Dinov
Journal of Neurochemistry

Monitoring the glycosylation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate )-type glutamate receptors using specific antibodies reveals a novel regulatory mechanism of N-glycosylation occupancy by molecular chaperones in Mice

Journal of NeurochemistryJanuary 21, 2020
Ryosuke MidorikawaKogo Takamiya
1
Molecular Neurobiology

Reduced Influence of apoE on Aβ43 Aggregation and Reduced Vascular Aβ43 Toxicity as Compared with Aβ40 and Aβ42

Molecular NeurobiologyJanuary 19, 2020
Lieke JäkelMarcel M Verbeek
3

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