Proteostasis enables the maintenance of protein homeostasis via modulation of protein translation, enhancement of chaperone capacity and the prompt clearance of misfolded proteins. It is affected in several neurodegenerative diseases. Here is the latest research.

September 16, 2021
Open Access

Regulating expression of mistranslating tRNAs by readthrough RNA polymerase II transcription

BioRxiv : the Preprint Server for Biology
Matthew D. BergC. J. Brandl
September 16, 2021

Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy.

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Tarun N BhatiaRehana K Leak
September 16, 2021

The Spread of Spectrin in Ataxia and Neurodegenerative Disease.

Journal of Experimental Neurology
Jon S Morrow, Michael C Stankewich
September 16, 2021

USP11 controls R-loops by regulating senataxin proteostasis.

Nature Communications
Mateusz JurgaSherif F El-Khamisy
September 16, 2021

Increased fidelity of protein synthesis extends lifespan.

Cell Metabolism
Victoria Eugenia Martinez-MiguelIvana Bjedov
September 16, 2021

The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Lukas Heintz, Catherine Meyer-Schwesinger
September 16, 2021

Deep proteome profiling of human mammary epithelia at lineage and age resolution.

Stefan HinzMark A LaBarge
September 15, 2021

Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns.

Cell Chemical Biology
Jagat K Chhipi-ShresthaMinoru Yoshida
September 15, 2021

Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter.

Cell Chemical Biology
Martin L ReadChristopher J McCabe
September 14, 2021
Open Access

Activation of endoplasmic reticulum stress via clustering of inner nuclear membrane proteins

BioRxiv : the Preprint Server for Biology
S. VidakTom Misteli
September 14, 2021
Open Access

Proteome signatures of reductive stress cardiomyopathy

BioRxiv : the Preprint Server for Biology
s. sunnyRajasekaran Namakkal-Soorappan
September 15, 2021

REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons.

Aging Cell
Anna RocchiFabio Benfenati
September 15, 2021

A role for mitochondrial DNA in cellular proteostasis.

Nature Reviews. Genetics
Caroline Barranco
September 15, 2021

The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces.

Proceedings of the National Academy of Sciences of the United States of America
Tom ScheidtTuomas P J Knowles
September 14, 2021
Open Access

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease.

Frontiers in Cell and Developmental Biology
Lidong WangZhen Liu

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