Proteotoxicity in Inflammation & Dementia

This feed focuses on proteotoxicity, which plays an important role in aging-associated inflammation of the CNS and is a major hallmark of different neurodegenerative disorders. Discover the latest research on proteotoxicity in inflammation and neurodegeneration here.

May 10, 2021
Open Access

SARS-CoV-2 vaccines: Lights and shadows.

European Journal of Internal Medicine
Fabio AngeliPaolo Verdecchia
May 5, 2021
Open Access

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy.

Acta Neuropathologica Communications
Ethan W HassBenoit I Giasson
May 1, 2021
Open Access

Progranulin in Neurodegenerative Dementia.

Journal of Neurochemistry
Xiao-Ming WangQing Tian
April 16, 2021
Open Access

Molecular Factors Mediating Neural Cell Plasticity Changes in Dementia Brain Diseases.

Neural Plasticity
Wojciech KozubskiJolanta Dorszewska
April 12, 2021
Open Access

Phosphoinositides: Roles in the Development of Microglial-Mediated Neuroinflammation and Neurodegeneration.

Frontiers in Cellular Neuroscience
Thomas Ernest James Phillips, Emily Maguire
April 9, 2021
Open Access

Tau strains shape disease.

Acta Neuropathologica
Jaime Vaquer-AliceaLukasz A Joachimiak
April 8, 2021
Open Access

Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies.

Acta Neuropathologica Communications
Connor BargarShu G Chen
April 4, 2021
Open Access

Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis.

Neurobiology of Disease
Jessica RootThomas Kukar
April 4, 2021
Open Access

Mechanisms of Neurodegeneration in Various Forms of Parkinsonism-Similarities and Differences.

Dariusz KoziorowskiAndrzej Friedman
April 3, 2021
Open Access

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism.

The Journal of Biological Chemistry
Jiahui TaoLisa McConlogue
March 27, 2021
Open Access

Prion-like C-Terminal Domain of TDP-43 and α-Synuclein Interact Synergistically to Generate Neurotoxic Hybrid Fibrils.

Journal of Molecular Biology
Shailendra DhakalVijayaraghavan Rangachari
March 24, 2021
Open Access

SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution

AnnaMaria MaraschiAntonia Ratti
March 18, 2021

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.

Human Molecular Genetics
Stephanie L RaynerAlbert Lee
March 12, 2021

S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.

Proceedings of the National Academy of Sciences of the United States of America
Elaine PirieStuart A Lipton
March 12, 2021
Open Access

Single molecule imaging of protein aggregation in Dementia: Methods, insights and prospects.

Neurobiology of Disease
John S H Danial, David Klenerman
March 10, 2021
Open Access

Brain region-specific spread of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.

Tim BartelsZane Jaunmuktane
March 9, 2021
Open Access

Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives.

Frontiers in Immunology
Tizibt Ashine BogaleArianna Bellucci

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