Proteotoxicity in Inflammation & Dementia

This feed focuses on proteotoxicity, which plays an important role in aging-associated inflammation of the CNS and is a major hallmark of different neurodegenerative disorders. Discover the latest research on proteotoxicity in inflammation and neurodegeneration here.

May 10, 2021
Review
Open Access

SARS-CoV-2 vaccines: Lights and shadows.

European Journal of Internal Medicine
Fabio AngeliPaolo Verdecchia
May 5, 2021
Open Access

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy.

Acta Neuropathologica Communications
Ethan W HassBenoit I Giasson
May 1, 2021
Review
Open Access

Progranulin in Neurodegenerative Dementia.

Journal of Neurochemistry
Xiao-Ming WangQing Tian
April 16, 2021
Review
Open Access

Molecular Factors Mediating Neural Cell Plasticity Changes in Dementia Brain Diseases.

Neural Plasticity
Wojciech KozubskiJolanta Dorszewska
April 12, 2021
Review
Open Access

Phosphoinositides: Roles in the Development of Microglial-Mediated Neuroinflammation and Neurodegeneration.

Frontiers in Cellular Neuroscience
Thomas Ernest James Phillips, Emily Maguire
April 9, 2021
Review
Open Access

Tau strains shape disease.

Acta Neuropathologica
Jaime Vaquer-AliceaLukasz A Joachimiak
April 8, 2021
Open Access

Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies.

Acta Neuropathologica Communications
Connor BargarShu G Chen
April 4, 2021
Review
Open Access

Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis.

Neurobiology of Disease
Jessica RootThomas Kukar
April 4, 2021
Review
Open Access

Mechanisms of Neurodegeneration in Various Forms of Parkinsonism-Similarities and Differences.

Cells
Dariusz KoziorowskiAndrzej Friedman
April 3, 2021
Open Access

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism.

The Journal of Biological Chemistry
Jiahui TaoLisa McConlogue
March 27, 2021
Open Access

Prion-like C-Terminal Domain of TDP-43 and α-Synuclein Interact Synergistically to Generate Neurotoxic Hybrid Fibrils.

Journal of Molecular Biology
Shailendra DhakalVijayaraghavan Rangachari
March 24, 2021
Preprint
Open Access

SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution

ResearchSquare
AnnaMaria MaraschiAntonia Ratti
March 18, 2021

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.

Human Molecular Genetics
Stephanie L RaynerAlbert Lee
March 12, 2021

S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.

Proceedings of the National Academy of Sciences of the United States of America
Elaine PirieStuart A Lipton
March 12, 2021
Review
Open Access

Single molecule imaging of protein aggregation in Dementia: Methods, insights and prospects.

Neurobiology of Disease
John S H Danial, David Klenerman
March 10, 2021
Preprint
Open Access

Brain region-specific spread of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.

ResearchSquare
Tim BartelsZane Jaunmuktane
March 9, 2021
Review
Open Access

Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives.

Frontiers in Immunology
Tizibt Ashine BogaleArianna Bellucci

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