Proteotoxicity in Inflammation & Dementia

This feed focuses on proteotoxicity, which plays an important role in aging-associated inflammation of the CNS and is a major hallmark of different neurodegenerative disorders. Discover the latest research on proteotoxicity in inflammation and neurodegeneration here.

October 13, 2021
Open Access

C9ORF72 Repeat Expansion Affects the Proteome of Primary Skin Fibroblasts in ALS.

International Journal of Molecular Sciences
Marta LualdiMauro Fasano
October 11, 2021

Loss-of-function mutation in VCP mimics the characteristic pathology as in FTLD-TARDBP.

Autophagy
Abubakar Wani, Conrad C Weihl
October 7, 2021
Review
Open Access

Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson's Disease.

Frontiers in Neuroscience
Alexandre IarkovValentina Echeverria
October 5, 2021

Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer's Disease.

Accounts of Chemical Research
Jiyeon HanMi Hee Lim
October 4, 2021

Asaronic acid inhibits ER stress sensors and boosts functionality of ubiquitin-proteasomal degradation in 7β-hydroxycholesterol-loaded macrophages.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Hyeongjoo OhYoung-Hee Kang
October 2, 2021

Solar simulated ultraviolet radiation inactivates HCoV-NL63 and SARS-CoV-2 coronaviruses at environmentally relevant doses.

Journal of Photochemistry and Photobiology. B, Biology
Georg T WondrakDominik Schenten
October 1, 2021
Open Access

Loss of presenilin function enhances tau phosphorylation and aggregation in mice.

Acta Neuropathologica Communications
Carlos M Soto-FaguásCarlos A Saura
October 1, 2021
Review

Defining circadian disruption in neurodegenerative disorders.

The Journal of Clinical Investigation
Christopher S Colwell
September 29, 2021
Review
Open Access

Alzheimer's Disease: A Molecular View of β-Amyloid Induced Morbific Events.

Biomedicines
Rajmohamed Mohamed AsikParasuraman Padmanabhan
September 29, 2021

Pharmacotherapeutic Potential of Garlic in Age-Related Neurological Disorders.

CNS & Neurological Disorders Drug Targets
Ramin Ahangar-SirousNiloofar Deravi
September 27, 2021
Review
Open Access

Nerve Growth Factor-Based Therapy in Alzheimer's Disease and Age-Related Macular Degeneration.

Frontiers in Neuroscience
Giuseppina AmadoroAlessandra Micera
September 23, 2021
Preprint
Open Access

Revisit the Cellular Transmission and Emerging Techniques in Proteinopathies

Preprints.org
JIngwen JiangQihui Wu
September 23, 2021
Review

Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives.

Ageing Research Reviews
Zhigang ZhangJie Tu
September 17, 2021
Review

A critical appraisal of tau-targeting therapies for primary and secondary tauopathies.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Bruno P ImbimboClaudia Balducci
September 16, 2021

Neuroinflammatory Signaling in the Pathogenesis of Alzheimer's Disease.

Current Neuropharmacology
Md Sahab UddinGhulam Md Ashraf
September 16, 2021

Control of hippocampal pKr-2 expression reduces neurotoxic symptoms in 5XFAD mice.

British Journal of Pharmacology
Sehwan KimSang Ryong Kim
September 14, 2021

Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders.

Acta Neuropathologica
Marzena Kurzawa-AkanbiChristopher M Morris
September 10, 2021
Open Access

Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.

Molecular Neurodegeneration
Grace M LloydDavid R Borchelt
September 10, 2021
Review
Open Access

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis.

International Journal of Molecular Sciences
Łucja Justyna Walczak-Nowicka, Mariola Herbet

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