PTEN Tumour Suppressor

PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation, survival and growth by inactivating PI 3-kinase-dependent signalling. It also suppresses cellular motility through mechanisms that may be partially independent of phosphatase activity. PTEN is one of the most commonly lost tumour suppressors in human cancer, and its deregulation is also implicated in several other diseases.

January 7, 2021
Open Access

Two tSNPs in BRIP1 are associated with breast cancer during TDT analysis

Molecular Genetics & Genomic Medicine
Xuefei LiJuan Huang
December 29, 2020

Differences in Genomic Alterations Between Brain Metastases and Primary Tumors

Neurosurgery
Antonio DonoLeomar Y Ballester
December 31, 2020
Open Access

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma

International Journal of Molecular Sciences
Peter KubatkaJan Mojzis
January 5, 2021
Case Report
Open Access

Utility of plasma cell-free DNA in metastatic castration-resistant prostate cancer

IJU Case Reports
Itsuto HamanoChikara Ohyama
January 15, 2021
Open Access

Targetable alterations in invasive pleomorphic lobular carcinoma of the breast

Breast Cancer Research : BCR
Gregory M RiedlingerShridar Ganesan
January 4, 2021
Preprint
Open Access

Comprehensive profiling of genomic and transcriptomic differences between risk groups of lung adenocarcinoma and lung squamous cell carcinoma

BioRxiv : the Preprint Server for Biology
T. Zengin, Tuğba Onal-Suzek
December 29, 2020
Open Access

Establishing a Urine-Based Biomarker Assay for Prostate Cancer Risk Stratification

Frontiers in Cell and Developmental Biology
Jinan GuoChang Zou
December 29, 2020
Open Access

EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma

Frontiers in Cell and Developmental Biology
Bin QiHao Chen

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