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PTEN Tumour Suppressor

PTEN Tumour Suppressor diagram by Swaminathan et al, Wikimedia
Swaminathan et al, Wikimedia

PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation, survival and growth by inactivating PI 3-kinase-dependent signalling. It also suppresses cellular motility through mechanisms that may be partially independent of phosphatase activity. PTEN is one of the most commonly lost tumour suppressors in human cancer, and its deregulation is also implicated in several other diseases.

Top 20 most recent papers
Toxicology in Vitro : an International Journal Published in Association with BIBRA

Secondary toxic effect of graphene oxide and graphene quantum dots alters the expression of miR-21 and miR-29a in human cell lines

Toxicology in Vitro : an International Journal Published in Association with BIBRAFebruary 20, 2020
Mahnaz Sadat HashemiAmin Shiralizadeh Dezfuli
Annals of Oncology : Official Journal of the European Society for Medical Oncology

Prognostic and predictive value of phosphorylated HER2, HER3 and PTEN expression in patients with HER2-positive breast cancer treated with trastuzumab

Annals of Oncology : Official Journal of the European Society for Medical OncologyFebruary 23, 2020
S Debska-SzmichP Potemski
Metabolic Brain Disease

Neuroprotective effects of miR-532-5p against ischemic stroke

Metabolic Brain DiseaseFebruary 23, 2020
Jingwei MuChuansheng Zhao
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology

Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway

Phytomedicine : International Journal of Phytotherapy and PhytopharmacologyFebruary 24, 2020
Zhanjun MaLi Lu
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Inhibition of MiR-122 Decreases Cerebral Ischemia-reperfusion Injury by Upregulating DJ-1-Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)/Phosphonosinol-3 Kinase (PI3K)/AKT

Medical Science Monitor : International Medical Journal of Experimental and Clinical ResearchFebruary 16, 2020
XinHong XueJiangLi Su
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology

Gegen Qinlian decoction maintains colonic mucosal homeostasis in acute/chronic ulcerative colitis via bidirectionally modulating dysregulated Notch signaling

Phytomedicine : International Journal of Phytotherapy and PhytopharmacologyFebruary 18, 2020
Yaxing ZhaoRuiyan Li

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