PTEN Tumour Suppressor

PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation, survival and growth by inactivating PI 3-kinase-dependent signalling. It also suppresses cellular motility through mechanisms that may be partially independent of phosphatase activity. PTEN is one of the most commonly lost tumour suppressors in human cancer, and its deregulation is also implicated in several other diseases.

July 24, 2020
Open Access

High-Plex and High-throughput Digital Spatial Profiling of non-small-cell lung cancer (NSCLC)

MedRxiv : the Preprint Server for Health Sciences
J. MonkmanArutha Kulasinghe
August 1, 2020
Open Access

Aberrant SOCS3 Promoter Methylation as a Noninvasive Diagnostic Biomarker for Locally Advanced Prostate Cancer

Medeniyet Medical Journal
Berna Demircan TanAsif Yildirim
August 5, 2020
Open Access

Quercetin-Resveratrol Combination for Prostate Cancer Management in TRAMP Mice

Chandra K SinghNihal Ahmad
August 2, 2020

Targeting the synthetic vulnerability of PTEN-deficient glioblastoma cells with MCL1 inhibitors

Molecular Cancer Therapeutics
Chao ChenFan Lin
August 4, 2020

Macropinocytosis: Insights from immunology and cancer

Current Opinion in Cell Biology
Jennifer L StowAdam A Wall
July 27, 2020

The function of SOX2 in breast cancer and relevant signaling pathway

Pathology, Research and Practice
Yanchun MengXichun Hu
July 29, 2020

The Prognostic Value of MRI Subventricular Zone Involvement and Tumor Genetics in Lower Grade Gliomas

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Gloria C ChiangIlhami Kovanlikaya
August 6, 2020
Case Report
Open Access

A Rare Complex BRAF Mutation Involving Codon V600 and K601 in Primary Cutaneous Melanoma: Case Report

Frontiers in Oncology
Francesca ConsoliWilliam Vermi
August 6, 2020
Open Access

Genomic Database Analysis of Uterine Leiomyosarcoma Mutational Profile

Annalisa AstolfiMaria Abbondanza Pantaleo
July 28, 2020
Open Access

Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer

Emma GervinMousumi Majumder
August 2, 2020

Therapeutic efficacy of modified anti-miR21 in metastatic prostate cancer

Biochemical and Biophysical Research Communications
Kyungmin KimHyewon Youn
July 27, 2020
Open Access

Defining relative mutational difficulty to understand cancer formation

Cell Discovery
Lin ShanHai Jiang

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