REDOX Signaling in Aging

The redox theory of aging is that aging is a decline in plasticity of genome-exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity.

January 17, 2022
Open Access

The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

BioRxiv : the Preprint Server for Biology
S. A. BansePatrick C Phillips
January 17, 2022

Aging of Volatile Organic Compounds in October 2017 Northern California Wildfire Plumes.

Environmental Science & Technology
Yutong LiangAllen H Goldstein
January 17, 2022

Myricetin: a Multifunctional Flavonol in Biomedicine.

Current Pharmacology Reports
Gopikrishna AgraharamKoyeli Girigoswami
January 17, 2022

ER reductive stress caused by Ero1α S-nitrosation accelerates senescence.

Free Radical Biology & Medicine
Xinhua QiaoChang Chen
January 16, 2022

Effect of Lycium barbarum polysaccharides on cell signal transduction pathways.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Youchao QiNing Peng
January 15, 2022

Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD.

Journal of Experimental Neurology
Reece CrumplerFan Fan
January 15, 2022

Curcuma longa L. Prevents the Loss of β-Tubulin in the Brain and Maintains Healthy Aging in Drosophila melanogaster.

Molecular Neurobiology
Md Mashiar RahmanTomasz M Karpiński
January 15, 2022

SRT1720 induces SIRT1-independent cell death in adult T-cell leukemia/lymphoma.

The FEBS Journal
Tomohiro KozakoShin-Ichiro Honda
January 15, 2022

A systematic review: metabolomics-based identification of altered metabolites and pathways in the skin caused by internal and external factors.

Experimental Dermatology
Viktor MasutinSimone Schmitz-Spanke
January 14, 2022

DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross-Sectional Study in Mice and Humans.

Journal of the American Heart Association
Rahul KumarSanjana Dayal
January 13, 2022

Parkinson's disease and diabetes mellitus: common mechanisms and treatment repurposing.

Neural Regeneration Research
Carmen M LabandeiraAna I Rodriguez-Perez
January 13, 2022

Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer's disease.

Neural Regeneration Research
Angie K TorresCheril Tapia-Rojas

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