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REDOX Signaling in Aging

REDOX Signaling in Aging diagram by OSweetNature, Shutterstock
OSweetNature, Shutterstock

The redox theory of aging is that aging is a decline in plasticity of genome-exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity.

Top 20 most recent papers
Frontiers in Cellular Neuroscience

Peroxisomal Dysfunction in Neurological Diseases and Brain Aging

Frontiers in Cellular NeuroscienceMarch 27, 2020
Ndidi-Ese UzorAndrey S Tsvetkov
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Differential responses of white adipose tissue and brown adipose tissue to calorie restriction during aging

The Journals of Gerontology. Series A, Biological Sciences and Medical SciencesMarch 31, 2020
Yunlu ShengGuoxian Ding
2
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology

Sirt3 is dispensable for oocyte quality and female fertility in lean and obese mice

FASEB Journal : Official Publication of the Federation of American Societies for Experimental BiologyMarch 27, 2020
Juvita D Iljas, Hayden A Homer
5
Current Neurovascular Research

Prospects and Perspectives for WISP1 (CCN4) in Diabetes Mellitus

Current Neurovascular ResearchMarch 29, 2020
Kenneth Maiese
1
Medicina clínica

New frontiers and clinical implications in the pathophysiology of age-related macular degeneration

Medicina clínicaMarch 22, 2020
Liria Yamamoto-RodríguezRicardo P Casaroli-Marano
3
Methods in Molecular Biology

Absolute Quantification of Plasma Apolipoproteins for Cardiovascular Disease Risk Prediction

Methods in Molecular BiologyMarch 29, 2020
Betul OzdemirNady Braidy
1
European Respiratory Review : an Official Journal of the European Respiratory Society

Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target

European Respiratory Review : an Official Journal of the European Respiratory SocietyMarch 22, 2020
Michael J HughesElizabeth Sapey
22
The Science of the Total Environment

Fenton aging significantly affects the heavy metal adsorption capacity of polystyrene microplastics

The Science of the Total EnvironmentMarch 22, 2020
Mengfan LangXuetao Guo

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