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REDOX Signaling in Aging

REDOX Signaling in Aging diagram by undefined

The redox theory of aging is that aging is a decline in plasticity of genome-exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity.

Top 20 most recent papers

Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline

bioRxivNovember 29, 2019
Anke HuelsThomas S. Wingo
Scientific Reports

Life-span extension by pigmented rice bran in the model yeast Saccharomyces cerevisiae

Scientific ReportsDecember 2, 2019
Pitchapat SunthonkunNitnipa Soontorngun
Scientific Reports

A multi-scale approach to study biochemical and biophysical aspects of resveratrol on diesel exhaust particle-human primary lung cell interaction

Scientific ReportsDecember 3, 2019
Wei ZhangAnhong Zhou
Analytical Chemistry

Single Particle Analysis for Structure and Iron Chemistry of Atmospheric Particulate Matter

Analytical ChemistryDecember 6, 2019
Jie DingLi-Ming Wang

Developmental ROS individualizes organismal stress resistance and lifespan

NatureDecember 4, 2019
Daphne BazopoulouUrsula Jakob
Experimental Gerontology

SOD1 deficiency alters gastrointestinal microbiota and metabolites in mice

Experimental GerontologyDecember 2, 2019
Haruka SagiTakahiko Shimizu
International Journal of Molecular Sciences

Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention

International Journal of Molecular SciencesNovember 26, 2019
Luca FaniaElena Dellambra

Vitamin E Supplementation and Mitochondria in Experimental and Functional Hyperthyroidism: A Mini-Review

NutrientsDecember 1, 2019
Gaetana NapolitanoPaola Venditti
Neurotoxicity Research

The Cannabinoid Receptor Agonist WIN55,212-2 Ameliorates Hippocampal Neuronal Damage After Chronic Cerebral Hypoperfusion Possibly Through Inhibiting Oxidative Stress and ASK1-p38 Signaling

Neurotoxicity ResearchDecember 5, 2019
Da-Peng WangJian Hai
Ecology Letters

The association between stressors and telomeres in non-human vertebrates: a meta-analysis

Ecology LettersNovember 27, 2019
Marion ChatelainMarta Szulkin
Environmental Science & Technology

The effect of aging on the stability of microbially-reduced uranium in natural sediments

Environmental Science & TechnologyNovember 26, 2019
Luca LoreggianRizlan Bernier-Latmani
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy

Polymorphism Of The APM1 Gene In Subjects With Central Obesity Related To Lower High-Density Lipoprotein Cholesterol

Diabetes, Metabolic Syndrome and Obesity : Targets and TherapyNovember 6, 2019
Melisa I BarlianaAjeng Diantini
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry

The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan of Saccharomyces Cerevisiae BY4742

Molecules : a Journal of Synthetic Chemistry and Natural Product ChemistryNovember 13, 2019
Chunxia GuoZhiqin Zhou
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry

Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging

Molecules : a Journal of Synthetic Chemistry and Natural Product ChemistryNovember 22, 2019
Diego AraunaIván Palomo
Advances in Gerontology = Uspekhi Gerontologii

Expression of heat shock proteins HSP70 under oxidative stress

Advances in Gerontology = Uspekhi GerontologiiJanuary 1, 2019
N A KurashovaLucie Kolesniková
Archives Animal Breeding

The effect of aging and muscle type on the quality characteristics and lipid oxidation of lamb meat

Archives Animal BreedingJuly 4, 2019
Witold RantMagdalena Slezak
Advances in Gerontology = Uspekhi Gerontologii

Stress-induced pathology and accelerated aging

Advances in Gerontology = Uspekhi GerontologiiJanuary 1, 2019
M N Torgashov, V S Myakotnykh
Oxidative Medicine and Cellular Longevity

LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss

Oxidative Medicine and Cellular LongevityOctober 27, 2019
Zhong-wu SuYi-Qing Zheng
Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie

Astrocytes autophagy in aging and neurodegenerative disorders

Biomedicine & Pharmacotherapy = Biomédecine & PharmacothérapieNovember 28, 2019
Jun-Ling Wang, Chao-Jin Xu
JACC. Basic to Translational Science

Atrial Myopathy

JACC. Basic to Translational ScienceSeptember 1, 2019
Mark J ShenJosé Jalife

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