REDOX Signaling in Aging

The redox theory of aging is that aging is a decline in plasticity of genome-exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity.

January 21, 2021
Open Access

Effects of Late-Life Caloric Restriction on Age-Related Alterations in the Rat Cortex and Hippocampus.

Claudia ToniniValentina Pallottini
January 23, 2021
Open Access

Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy.

International Journal of Molecular Sciences
Marlena Typiak, Agnieszka Piwkowska
January 21, 2021
Open Access

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases.

Carmine IzzoCarmine Vecchione
January 19, 2021
Open Access

DUOX2 participates in skin aging induced by UVB in HSF2 cells by activating NF-κB signaling

Experimental and Therapeutic Medicine
Xiaoqing XiaoFuguo Zuo
January 16, 2021
Open Access

Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites

International Journal of Molecular Sciences
Kenneth K Wu
January 19, 2021
Open Access

Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients

Oxidative Medicine and Cellular Longevity
Francisco J SánchezEmiliano R Diez
January 24, 2021
Open Access

Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration.

Journal of Neuroinflammation
Keng Siang LeeJian Liu
January 22, 2021

Preserving transcriptional stress responses as an anti-aging strategy.

Aging Cell
Yang ChengDirk Bohmann
January 17, 2021

Slowed protein turnover in aging Drosophila reflects a shift in cellular priorities

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Evelyn S VincowLeo J Pallanck
January 16, 2021
Open Access

Reduced RNA turnover as a driver of cellular senescence

Life Science Alliance
Nowsheen MullaniChristian Muchardt
January 21, 2021
Open Access

The Neuromelanin Paradox and Its Dual Role in Oxidative Stress and Neurodegeneration.

Alexandra Moreno-GarcíaOlga Calero
January 18, 2021

Helix pomatia albumen gland water soluble protein extract as powerful antiaging agent.

Experimental Gerontology
Gohar TsakanovaArsen Arakelyan
January 21, 2021
Open Access

Fatigability and Cardiorespiratory Impairments in Parkinson's Disease: Potential Non-Motor Barriers to Activity Performance.

Journal of Functional Morphology and Kinesiology
Andrew E PechsteinAndrew A Guccione
January 18, 2021

Coenzyme Q homeostasis in aging: response to non-genetic interventions

Free Radical Biology & Medicine
Guillermo López-Lluch

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