Researcher Network:CZI Neurodegeneration Challenge

The Neurodegeneration Challenge Network aims to provide funding for and to bring together researchers studying neurodegenerative diseases. Find the latest research from the NDCN grantees here.

January 15, 2022

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.

Nature Cell Biology
Avi J SamelsonMartin Kampmann
January 15, 2022

Neurocognitive profile of adults with the Norrbottnian type of Gaucher disease.

JIMD Reports
Panagiota TsitsiPer Svenningsson
January 15, 2022

High-Throughput, High-Multiplex Digital Protein Detection with Attomolar Sensitivity.

ACS Nano
Connie WuDavid R Walt
January 13, 2022
Preprint
Open Access

Scalable in situ single-cell profiling by electrophoretic capture of mRNA

BioRxiv : the Preprint Server for Biology
L. BormS. Linnarsson
January 12, 2022
Preprint
Open Access

Developmental origins of cell heterogeneity in the human lung

BioRxiv : the Preprint Server for Biology
A. SountoulidisChristos Samakovlis
January 12, 2022
Open Access

The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice.

International Journal of Molecular Sciences
Vandana VeenitPer Svenningsson
January 12, 2022
Review

SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding.

Nature Protocols
Sofia A QuinodozMitchell Guttman
January 12, 2022

A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.

Annals of Clinical and Translational Neurology
Jonathan S KatzJonathan D Glass
January 10, 2022
Open Access

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

Acta Neuropathologica Communications
Erwan LambertPierre Dourlen
January 9, 2022
Preprint
Open Access

Intravenous gene transfer throughout the brain of infant Old World primates using AAV

BioRxiv : the Preprint Server for Biology
Miguel R ChuapocoViviana Gradinaru
January 9, 2022
Review

Somatosensory and autonomic neuronal regulation of the immune response.

Nature Reviews. Neuroscience
Swalpa UditIsaac M Chiu
January 8, 2022
Review

Engineering brain assembloids to interrogate human neural circuits.

Nature Protocols
Yuki MiuraSergiu Pasca
January 7, 2022

Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Mitchell C KrawczykYe Zhang
January 7, 2022
Review
Open Access

Presynaptic Autophagy and the Connection With Neurotransmission.

Frontiers in Cell and Developmental Biology
Marianna Decet, Patrik Verstreken
January 6, 2022

Glutamate in primary afferents is required for itch transmission.

Neuron
Lian CuiWenqin Luo
January 5, 2022

Influence of periaqueductal gray on other salience network nodes predicts social sensitivity.

Human Brain Mapping
Myrthe G RijpmaKatherine P Rankin
January 4, 2022
Preprint
Open Access

Dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification

BioRxiv : the Preprint Server for Biology
S. KolayMarc I Diamond
January 3, 2022
Preprint
Open Access

Seed-competent tau monomer initiates pathology in PS19 tauopathy mice

BioRxiv : the Preprint Server for Biology
H. MirbahaMarc I Diamond

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