RGC: Proteasome & Lysosome

Mitochondrial dysfunction in Retinal Ganglion Cells (RGCs) may lead to optical neuropathies. Possible mechanisms involved improper degradation of the mitochondria by the lysosome and proteosome. Discover the latest research here.

January 8, 2019
Open Access

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

Cell
Jean-Michel CioniChristine E Holt
March 12, 2020
Open Access

Testosterone increases apoptotic cell death and decreases mitophagy in Leber's hereditary optic neuropathy cells

Journal of Applied Genetics
Elona JankauskaitėAgata Kodroń
October 3, 2018

Insights on the intracellular trafficking of PDMAEMA gene therapy vectors

Materials Science & Engineering. C, Materials for Biological Applications
Diogo B BitoqueGabriela A Silva
April 10, 2017
Open Access

Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa

Stem Cell Research
Tasneem P SharmaEdwin M Stone
August 28, 2016
Review

Autophagy in the eye: Development, degeneration, and aging

Progress in Retinal and Eye Research
Patricia BoyaBeatriz Villarejo-Zori
November 11, 2018
Open Access

Overexpression of acid ceramidase (ASAH1) protects retinal cells (ARPE19) from oxidative stress

Journal of Lipid Research
Eriko SuganoNawajes Mandal
October 12, 2018
Open Access

Mitophagy activation repairs Leber's hereditary optic neuropathy-associated mitochondrial dysfunction and improves cell survival

Human Molecular Genetics
Lokendra Kumar SharmaYidong Bai
January 26, 2018
Open Access

Overexpression of parkin protects retinal ganglion cells in experimental glaucoma

Cell Death & Disease
Yi DaiXinghuai Sun
November 7, 2018
Preprint
Open Access

Mitochondrial Uncoupling Protein 2 Knockout Promotes Mitophagy to Decrease Retinal Ganglion Cell Death in Glaucoma

BioRxiv : the Preprint Server for Biology
Daniel T Hass, Colin J Barnstable
December 13, 2018
Open Access

Mitochondrial Fission Is Required for Blue Light-Induced Apoptosis and Mitophagy in Retinal Neuronal R28 Cells

Frontiers in Molecular Neuroscience
Jia-Yu LiXiao-Jian Han
December 17, 2016
Review
Open Access

Why autophagy is good for retinal ganglion cells?

Eye
Patricia Boya
April 20, 2018

Circadian Regulation of Mitochondrial Dynamics in Retinal Photoreceptors

Journal of Biological Rhythms
Janet Ya-An ChangGladys Y-P Ko
November 20, 2016
Open Access

OPA1 haploinsufficiency induces a BNIP3-dependent decrease in mitophagy in neurons: relevance to Dominant Optic Atrophy

Journal of Neurochemistry
Manon F MoulisPascale Belenguer
June 15, 2017
Comment / Editorial
Open Access

BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming

Autophagy
Lorena Esteban-Martínez, Patricia Boya
May 19, 2018
Review

Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Eye Diseases

Advances in Experimental Medicine and Biology
C Randall HarrellVladislav Volarevic
May 12, 2017
Open Access

TXNIP regulates mitophagy in retinal Müller cells under high-glucose conditions: implications for diabetic retinopathy

Cell Death & Disease
Takhellambam Swornalata DeviLalit Pukhrambam Singh

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