Rho GTPases & Cancer Progression

Expression levels and/or activity of Rho GTPases is altered in most cancers. Rho GTPase signaling could therefore be therapeutically targeted in cancer treatment.

September 6, 2020

Non-canonical EphA2 signaling is a driver of tumor-endothelial cell interactions and metastatic dissemination in BRAF inhibitor resistant melanoma

The Journal of Investigative Dermatology
Chao ZhangKeiran S M Smalley
September 6, 2020
Open Access

TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming

BioRxiv : the Preprint Server for Biology
Christopher G ProudT. J. Sargeant
August 21, 2020

Coordinated dysregulation of cancer progression by the HER family and p21-activated kinases

Cancer Metastasis Reviews
Rakesh KumarM Radhakrishna Pillai
September 20, 2020

Identifying Cancer-Relevant Mutations in the DLC START Domain using Evolutionary and Structure-Function Analyses

BioRxiv : the Preprint Server for Biology
A. S. HolubAman Y Husbands
July 29, 2020
Open Access

RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A

Scientific Reports
Lukas RichterGudula Schmidt
September 16, 2020

Development of a New and Improved Guanidine-based Rac1 Inhibitor with in Vivo Activity against Non-Small Cell Lung Cancer

ChemRxiv : the Preprint Server for Chemistry
Matias S CiarlantiniMaria Julieta Comin
May 13, 2020
Open Access

Dysregulation of Rho GTPases in Human Cancers

Haiyoung JungHee Gu Lee
August 15, 2020
Open Access

Comprehensive Analysis of the Immune Implication of ACK1 Gene in Non-small Cell Lung Cancer

Frontiers in Oncology
Jinhong ZhuJianqun Ma
September 17, 2020

RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion

BioRxiv : the Preprint Server for Biology
W. FicDaniel St Johnston
August 26, 2020

RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?

Critical Reviews in Biochemistry and Molecular Biology
Richard G HodgeChanning J Der
August 11, 2020
Open Access

Rho GTPases in cancer radiotherapy and metastasis

Cancer Metastasis Reviews
Rui-Jie ZengEn-Min Li

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