RNA in Neurodegeneration

While a link has been established between RNA, RNA-binding proteins, and motor proteins, mechanisms underlying RNA trafficking are still unclear. Furthermore, interactions between cargo and motor proteins are dysregulated in microsatellite repeat expansion diseases, including Huntington’s disease. Here is the latest research focusing on RNA trafficking and neurodegeneration.

November 14, 2020
Open Access

Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes

Neurobiology of Disease
Rebecca L KowBrian C Kraemer
December 11, 2020
Open Access

TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage

PLoS Genetics
Marta GianniniAndrés Aguilera
December 29, 2020

Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock

Cellular Signalling
Amber A ParnellLisa C Lyons
January 16, 2021
Review

FUS and TDP-43 Phases in Health and Disease

Trends in Biochemical Sciences
Bede PortzJames Shorter
December 18, 2020
Open Access

Coiled-Coil Motifs of RNA-Binding Proteins: Dynamicity in RNA Regulation

Frontiers in Cell and Developmental Biology
Lenzie K Ford, Luana Fioriti
December 8, 2020
Review
Open Access

Stress Granule Dysregulation in Amyotrophic Lateral Sclerosis

Frontiers in Cellular Neuroscience
Jessica Dudman, Xin Qi
November 11, 2020
Open Access

The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice

The Journal of Biological Chemistry
Jesse SundarVisvanathan Ramamurthy
December 4, 2020
Open Access

HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex

Neurobiology of Disease
Michela Dell'OrcoCristina Cereda
January 12, 2021
Review
Open Access

Matrin 3 in neuromuscular disease: physiology and pathophysiology

JCI Insight
Ahmed M Malik, Sami J Barmada
December 23, 2020
Review
Open Access

The multi-functional RNA binding protein G3BP1 and its potential implication in neurodegenerative disease

Journal of Neurochemistry
Hadjara SidibéChristine Vande Velde
December 19, 2020

HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

Science
Haiyang YuDon W Cleveland
November 12, 2020
Open Access

Stress-Specific Spatiotemporal Responses of RNA-Binding Proteins in Human Stem-Cell-Derived Motor Neurons

International Journal of Molecular Sciences
Jasmine Harley, Rickie Patani
January 12, 2021
Open Access

The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice

The Journal of Biological Chemistry
Jesse SundarVisvanathan Ramamurthy
December 16, 2020
Preprint
Open Access

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.

BioRxiv : the Preprint Server for Biology
I. Sanjuan-RuizLuc Dupuis
January 5, 2021
Review
Open Access

The Emerging Roles of Autophagy-Related MicroRNAs in Cancer

International Journal of Biological Sciences
Chan ShanKun Wang
January 7, 2021

An Emerging Role of miRNAs in Neurodegenerative Diseases: Mechanisms and Perspectives on miR146a

Antioxidants & Redox Signaling
Navneet Ammal KaideryBobby Thomas

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