RNA in Neurodegeneration

While a link has been established between RNA, RNA-binding proteins, and motor proteins, mechanisms underlying RNA trafficking are still unclear. Furthermore, interactions between cargo and motor proteins are dysregulated in microsatellite repeat expansion diseases, including Huntington’s disease. Here is the latest research focusing on RNA trafficking and neurodegeneration.

January 15, 2022
Open Access

Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease.

Communications Biology
Gabriela NovakAlexander Skupin
January 14, 2022
Open Access

Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model.

Journal of Neuroinflammation
Yuan Chao XueHonglin Luo
January 12, 2022
Preprint
Open Access

A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration

BioRxiv : the Preprint Server for Biology
Yichang Jia
January 12, 2022
Review
Open Access

Insights into the multifaceted role of circular RNAs: implications for Parkinson's disease pathogenesis and diagnosis.

NPJ Parkinson's Disease
Epaminondas Doxakis
January 11, 2022
Review
Open Access

Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis.

Frontiers in Neuroscience
Bridget C BensonGuillaume M Hautbergue
January 6, 2022

Assays to Study IRE1 Activation and Signaling.

Methods in Molecular Biology
Paloma MoragaClaudio Hetz
January 4, 2022
Preprint
Open Access

The Mitochondrial RNA Granule is Necessary for Parkinsonism-Associated Metal Toxicity

BioRxiv : the Preprint Server for Biology
E. WernerVictor Faundez
January 3, 2022
Review
Open Access

DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication.

Frontiers in Molecular Neuroscience
Haibo WangMuralidhar L Hegde
December 31, 2021

mRNA-Binding Protein DJ-1 as a pivotal protein in AD pathology.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Ayse UneriKimberly F Raab-Graham
December 31, 2021

Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Samuel Walter HershTsuneya Ikezu
December 25, 2021
Open Access

Failure to Upregulate the RNA Binding Protein ZBP After Injury Leads to Impaired Regeneration in a Rodent Model of Diabetic Peripheral Neuropathy.

Frontiers in Molecular Neuroscience
James I JonesDianna E Willis
December 23, 2021

New lessons on TDP-43 from old N. furzeri killifish.

Aging Cell
Alexandra LoukaEva Terzibasi Tozzini
December 22, 2021

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep.

JCI Insight
Chantal M FergusonAnastasia Khvorova
December 22, 2021
Review
Open Access

TDP-43 Pathology in Alzheimer's Disease.

Molecular Neurodegeneration
Axel MenesesNa Zhao

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