RNA-mediated Toxicity in Neurodegeneration

Some neurodegenerative disorders are believed to be due to RNA-induced cellular toxicity caused by the expansion of nucleotide-repeat sequences in DNA. Discover the latest research on RNA-mediated toxicity in neurodegeneration here.

January 14, 2022

AAV9/MFSD8 gene therapy is effective in preclinical models of neuronal ceroid lipofuscinosis type 7 disease.

The Journal of Clinical Investigation
Xin ChenSteven J Gray
January 13, 2022

Mesenchymal stem cell secretome protects against oxidative stress-induced ocular blast visual pathologies.

Experimental Eye Research
Kumar Abhiram JhaRajashekhar Gangaraju
January 12, 2022
Preprint
Open Access

A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration

BioRxiv : the Preprint Server for Biology
Yichang Jia
January 12, 2022
Open Access

Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis.

International Journal of Molecular Sciences
Joanna I LachowiczPierpaolo Coni
January 12, 2022
Review
Open Access

LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights.

Cells
Patrick D SkeltonLoukia Parisiadou
January 11, 2022
Open Access

Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer's Disease.

Frontiers in Pharmacology
Giuseppe CarusoFilippo Caraci
January 11, 2022

Elevated granulocyte-colony stimulating factor and hematopoietic stem cell mobilization in Niemann-Pick Type C1 disease.

Journal of Lipid Research
Anouk G GroenenMarit Westerterp
January 7, 2022

Aminochrome Induces Neuroinflammation and Dopaminergic Neuronal Loss: A New Preclinical Model to Find Anti-inflammatory and Neuroprotective Drugs for Parkinson's Disease.

Cellular and Molecular Neurobiology
Fillipe Mendes De AraújoVictor Diógenes Amaral Silva
January 6, 2022
Review

Therapy development for spinal muscular atrophy: perspectives for muscular dystrophies and neurodegenerative disorders.

Neurological Research and Practice
Sibylle JablonkaMichael Sendtner
January 6, 2022

Drosophila Unfolded Protein Response (UPR) Assays In Vitro and In Vivo.

Methods in Molecular Biology
Hidetaka KatowHyung Don Ryoo
January 3, 2022
Open Access

Selected Thiadiazine-Thione Derivatives Attenuate Neuroinflammation in Chronic Constriction Injury Induced Neuropathy.

Frontiers in Molecular Neuroscience
Sonia QureshiSami Ullah
December 31, 2021

Pathogenic tauR406W induced neurodegeneration and memory deficits rescued by HDAC6 null mutation in Drosophila melanogaster.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Arkajyoti Sarkar, Sahabudeen Sheik Mohideen
December 29, 2021

Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression.

Pharmaceutics
Xu-Qiao ChenMaria L Maccecchini
December 27, 2021

Combined molecular, structural and memory data unravel the destructive effect of tramadol on hippocampus.

Neuroscience Letters
Aysan KhatmiAbbas Aliaghaei
December 27, 2021

Myelin-associated glycoprotein activation triggers glutamate uptake by oligodendrocytes in vitro and contributes to ameliorate glutamate-mediated toxicity in vivo.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
Ana L VivinettoPablo H H Lopez
December 28, 2021

Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer's disease pathology in a mouse model.

Progress in Neurobiology
Zhi-Hao WangKeqiang Ye
December 26, 2021
Review

RAN proteins in neurodegenerative disease: Repeating themes and unifying therapeutic strategies.

Current Opinion in Neurobiology
Shu GuoLaura P W Ranum

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