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RNA & Tau in Frontotemporal Dementia

RNA & Tau in Frontotemporal Dementia diagram by ibreakstock, Shutterstock
ibreakstock, Shutterstock

Tau mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) are associated with changes in alternative RNA splicing. Here is the latest research on RNA & Tau in Frontotemporal Dementia.

Top 20 most recent papers
Journal of Neurology, Neurosurgery, and Psychiatry

Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

Journal of Neurology, Neurosurgery, and PsychiatryJanuary 16, 2020
Carolin HellerGENFI
25
1
Science Translational Medicine

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

Science Translational MedicineDecember 20, 2019
Jeanna M WheelerBrian C Kraemer
53
12
2
bioRxiv

Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair

bioRxivDecember 20, 2019
Nidaa AbabnehKevin Talbot
20
bioRxiv

TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression

bioRxivDecember 13, 2019
Josiah J. HerzogSuzanne Paradis
2
bioRxiv

Human tauopathies are not associated with an activated unfolded protein response

bioRxivDecember 22, 2019
A. P. PiteraK. Deinhardt
10
Neurology

REM sleep atonia loss distinguishes synucleinopathy in older adults with cognitive impairment

NeurologyDecember 14, 2019
Stuart J McCarterErik K St Louis
3
1
JAMA Neurology

Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia

JAMA NeurologyDecember 21, 2019
Andy J LiuAimee W Kao
16
1
1
Acta Neuropathologica

Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy

Acta NeuropathologicaJanuary 8, 2020
Isidro FerrerJosé Antonio Del Rio
2
Neuron

Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model

NeuronDecember 14, 2019
Lien NguyenLaura P W Ranum
19
2
bioRxiv

Data-driven algorithm for the diagnosis of behavioral variant frontotemporal dementia

bioRxivDecember 20, 2019
Ana L. ManeraGENetic Frontotemporal dementia Initiative (GENFI)
7
Cells

Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice

CellsJanuary 18, 2020
Marangelie Criado-MarreroAnd Laura J Blair
Journal of Neurochemistry

Tau protein phosphorylation at Thr175 initiates fibril formation via accessibility of the N-terminal phosphatase-activating domain

Journal of NeurochemistryDecember 20, 2019
Matthew A HintermayerMichael J Strong
1
1
Frontiers in Neuroscience

Seeding Activity-Based Detection Uncovers the Different Release Mechanisms of Seed-Competent Tau Versus Inert Tau via Lysosomal Exocytosis

Frontiers in NeuroscienceDecember 12, 2019
Yuki TanakaTakeshi Iwatsubo
5
1
3
Frontiers in Aging Neuroscience

The MAPT H1 Haplotype Is a Risk Factor for Alzheimer's Disease in APOE ε4 Non-carriers

Frontiers in Aging NeuroscienceDecember 24, 2019
Pascual Sánchez-JuanAgustín Ruiz
8
1
6
JAMA Network Open

Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

JAMA Network OpenDecember 12, 2019
Jorge J Llibre-GuerraEric McDade
24
1
bioRxiv

Analysis of brain atrophy and local gene expression implicates astrocytes in Frontotemporal dementia

bioRxivDecember 12, 2019
Andre Altmannon behalf of the Genetic FTD Initiative, GENFI.
21
Trends in Genetics : TIG

New Roles for Canonical Transcription Factors in Repeat Expansion Diseases

Trends in Genetics : TIGDecember 16, 2019
Lindsey D Goodman, Nancy M Bonini
9
1
Biomaterials

Self-assembly hollow manganese Prussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline

BiomaterialsDecember 22, 2019
Xiaojun CaiHangrong Chen
2
1
Translational Neurodegeneration

δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities

Translational NeurodegenerationJanuary 9, 2020
Zhentao ZhangKeqiang Ye
1
ACS Chemical Neuroscience

Evaluation of [18 F]N-methyl-lansoprazole as a tau PET imaging agent in first-in-human studies

ACS Chemical NeuroscienceJanuary 4, 2020
Vasko KramerPatrick J Riss
4
1

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